Genetic Mechanisms of Synaptic Plasticity in Neuropsychiatric Disorders
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 April 2026 | Viewed by 1
Special Issue Editor
2. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Interests: synaptic plasticity; synaptic physiology; cognition; antidepressants; depression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Synaptic plasticity lies at the heart of cognition, learning, and emotional regulation—and its disruption represents a shared thread across many neuropsychiatric disorders. This Special Issue of Genes invites original research and reviews that explore how genetic and epigenetic factors shape the molecular and cellular mechanisms of synaptic plasticity. We are particularly interested in studies that bridge levels of analysis—from gene discovery and molecular signaling to circuit dynamics and behavioral outcomes—in models or patient-derived systems relevant to autism, schizophrenia, depression, and related conditions. Submissions addressing emerging technologies, multi-omics approaches, and integrative frameworks that link genetic perturbations to circuit dysfunction are especially encouraged. By bringing together diverse perspectives, this Special Issue aims to advance a comprehensive understanding of how genetic mechanisms of synaptic plasticity contribute to neuropsychiatric disease and to inspire new strategies for restoring synaptic and behavioral health.
Dr. Lace Riggs
Guest Editor
Manuscript Submission Information
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Keywords
- synaptic plasticity
- neuropsychiatric disorders
- autism spectrum disorder
- schizophrenia
- depression
- epigenetic regulation
- synaptic signaling
- circuit dysfunction
- gene–circuit interactions
- molecular neuroscience
- translational neurogenetics
- epigenetics
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