3D Chromatin Architecture: From Computational Algorithms to Biological Functions
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Bioinformatics".
Deadline for manuscript submissions: 20 October 2026 | Viewed by 170
Editor
Special Issue Information
Dear Colleagues,
Since the introduction of Hi-C and ChIA-PET techniques in 2009, high-throughput sequencing methods for probing three-dimensional genome organization have advanced many subfields of biology, including developmental biology, cancer genomics, and immunology. Recent techniques offer an unprecedented resolution at the single-cell level and are often coupled with other modalities, such as gene transcription, open chromatin regions, and histone modifications.
This Special Issue aims to highlight the importance of genome organization in various cellular contexts. We seek contributions from authors developing computational algorithms to accurately and efficiently interpret 3D genome mapping data. Examples include applications of machine learning, signal processing, and graph theory for the interpretation of bulk-cell and single-cell 3D genomics data. Another direction is the application of experimental techniques to biological systems to delineate the molecular mechanisms by which biological functions are determined by the structure, and vice versa. Integration with other data modalities is also encouraged for holistic viewpoints.
Dr. Minji Kim
Guest Editor
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Keywords
- 3D genomics
- computational algorithm
- genome organization
- gene regulation
- molecular mechanism
- functional elements
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