Sperm DNA Changes: Causes, Diagnostics, and Implications for Fertility and Offspring Health
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Genetic Diagnosis".
Deadline for manuscript submissions: 10 October 2026 | Viewed by 72
Special Issue Editors
2. Department of Translational Medicine, Lund University, Lund, Sweden
3. Department of Laboratory Medicine, Lund University, Lund, Sweden
Interests: reproductive medicine; sperm DNA
Interests: cell culture; gene expression; DNA sequencing; genomics; gene regulation; next generation sequencing; epigenetics; regulation of gene expression; transcription; transcriptional regulation; DNA methylation; gene expression and chromatin biology; chromatin; methylation; histone modification; epigenomics; ChIP-sequencing; chromatin remodeling; chromatin structure; chromatin biology; embryonic stem cell culture and differentiation; enhancer regulation
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Special Issue Information
Dear Colleagues,
The understanding of the importance of sperm DNA has gradually been increasing. Examples of this include the association between sperm DNA fragmentation and a lower chance of achieving pregnancy, risk of preeclampsia in the female partner, and the risk of malformations.
On top of this, a man’s age has been shown to be associated with the number of new mutations in his sperm DNA, as well as with de novo mutations in the offspring and with several diseases in the offspring, which themselves can be due to de novo mutations.
Several techniques are used to measure sperm DNA fragmentation, and the techniques used to measure the frequencies of mutations in sperm DNA are continuously evolving, such as error-corrected sequencing. Epigenetic changes of sperm DNA have also been discussed as mechanisms of causing health-related effects in offspring.
This Special Issue will shed new light on the importance of different kinds of changes in sperm DNA, their causal factors, mechanisms, and different outcomes of health in both the man himself, his partner and in the coming child.
Dr. Jonatan Axelsson
Dr. Humaira Gowher
Guest Editors
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Keywords
- sperm DNA
- sperm DNA fragmentation
- germ cell mutations
- de novo mutations
- offspring effects
- infertility
- sperm chromatin structure
- epigenetics
- lifestyle
- environmental effects
- error-corrected sequencing
- aneuploidy
- chromosome aberrations
- pregnancy
- child
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