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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic, Epigenetic and Environmental Factors in Dental Development and Pathologies: Genes, Interactions and Dental Development

edited by

Alan H. Brook

submission deadline 5 Nov 2025 | 17 articles | Viewed by 50758

Keywords: dental development; genetics; epigenetics; complex adaptive systems; interactive networks

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Motor Neuron Diseases

edited by

Christopher Grunseich

submission deadline 5 Nov 2025 | Viewed by 355

Keywords: motor neuron disease; familial amyotrophic lateral sclerosis (fALS); gene therapy; antisense oligonucleotides (ASOs); precision medicine; novel therapeutic approaches

(This special issue belongs to the Section Neurogenomics)

Pharmacogenomics and Personalized Treatment

edited by

Livija Šimičević

and Lana Ganoci

submission deadline 10 Nov 2025 | 2 articles | Viewed by 1345 | Submission Open

Keywords: pharmacogenomics; personalized treatment; genetic biomarkers; drug metabolism; gene– drug interactions; genetic variation; clinical pharmacogenomics

(This special issue belongs to the Section Pharmacogenetics)

Advances in Gene Therapy

edited by Ryan Butler

submission deadline 10 Nov 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: gene therapy; rare diseases; viral vectors; RNA silencing; gene editing; methylation editing

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Pharmacogenomics of Human Diseases

edited by

Maria Papasavva

and Alexander Haliassos

submission deadline 10 Nov 2025 | Viewed by 508 | Submission Open

Keywords: pharmacogenomics; precision medicine; genetic variants; disease susceptibility; clinical genetics; individualized treatment; biomarkers

(This special issue belongs to the Section Pharmacogenetics)

Genetics and Genomics of Lung Cancer

edited by Elisa Frullanti

submission deadline 10 Nov 2025 | Viewed by 459 | Submission Open

Keywords: lung cancer; genetic variants; genomics; biomarkers; pharmacogenomics; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Autism Spectrum Disorders

edited by

Roberto Canitano

and

Marco Carotenuto

submission deadline 15 Nov 2025 | 1 articles | Viewed by 820 | Submission Open

Keywords: autism spectrum disorders; genetics; new techniques for diagnosis

(This special issue belongs to the Section Neurogenomics)

Advances in Genomics and Epigenetics of Hearing Loss

edited by Alessandro Castiglione

submission deadline 15 Nov 2025 | Viewed by 194 | Submission Open

Keywords: genetics; hearing loss; inner ear; epigenetics; auditory system

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Next-Generation Sequencing in Rare Genetic Diseases

edited by

Edoardo Errichiello

and

Paola Dimartino

submission deadline 15 Nov 2025 | Viewed by 187 | Submission Open

Keywords: rare genetic diseases; next-generation sequencing; bioinformatics; multiomics data; artificial intelligence; gene discovery; single nucleotide variants; structural variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Immunogenetics and Functional Genomics of Insects

edited by

Zhizhi Wang

and Fei Wang

submission deadline 15 Nov 2025 | Viewed by 123 | Submission Open

Keywords: host– microbe interaction; microbial infection; insect immunity; immune gene evolution; innmue response; crosstalk

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Cancer Immunology

edited by

Jing Yang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1885 | Submission Open

Keywords: tumor– immune interaction; immunotherapy; immune regulation; immune evasion

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding Improvements in Sheep and Goat

edited by

Kaiping Deng

submission deadline 20 Nov 2025 | 1 articles | Viewed by 806 | Submission Open

Keywords: genetics; breeding improvement; genomic selection; molecular markers

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Analysis of Hepatitis Virus Infection

edited by

Dan Florin Mihǎilescu

and

Maria Alexandra Mernea

submission deadline 20 Nov 2025 | Viewed by 236 | Submission Open

Keywords: hepatitis virus; viral genomics; host genetics; immune response; biomarkers; pathogenesis; next-generation sequencing; personalized medicine; gene– environment interactions; antiviral therapy

(This special issue belongs to the Section Viral Genomics)

HTAAD: Unraveling the Molecular and Clinical Complexity of Heritable Thoracic Aortic Disease

edited by

Guglielmina Pepe

, Rossella Fattori,

Stefano Nistri

and Yskert von Kodolitsch

submission deadline 20 Nov 2025 | Viewed by 162 | Submission Open

Keywords: syndromic and non-syndromic HTAAD; Loeys– Dietz syndrome; Marfan syndrome; vascular Ehlers– Danlos syndrome; bicuspid aortic valve; genotype– phenotype correlation; next-generation sequencing (NGS) and omics technologies; extracellular matrix; TGF-β signaling pathway and smooth muscle cell contraction genes; iconodiagnostic

(This special issue belongs to the Section Genetic Diagnosis)

Application of Sequencing Technologies in Cancers

edited by Limin Chen

submission deadline 20 Nov 2025 | Viewed by 162 | Submission Open

Keywords: sequencing technologies; single-cell; spatial transcriptomics; cancer

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Adaptation and Evolutionary Genetics in Plants

edited by Wei Zhang

submission deadline 24 Nov 2025 | 6 articles | Viewed by 4973 | Submission Open

Keywords: molecular evolution; plastid genome; mitochondrial genome; nuclear genome; gene family

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Genetics and Pathogenesis of Motor Neuron Disease

edited by Tadashi Nakagawa

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2421 | Submission Open

Keywords: motor neuron disease; molecular genetics; molecular and cellular analyses; phenotypic characterization; therapeutic development; clinical applications; omic technologies

(This special issue belongs to the Section Neurogenomics)

15th Anniversary of Genes: Feature Papers in “Neurogenetics and Neurogenomics”

edited by

Claudia Ricci

and Micheal Palladino

submission deadline 25 Nov 2025 | 3 articles | Viewed by 2223 | Submission Open

Keywords: genomics; neurological diseases; multi-omics studies; brain development and function; precision medicine; pathogenic mechanisms

(This special issue belongs to the Section Neurogenomics)

Advances in Developing Genomics and Computational Approaches

edited by

Abedalrhman Alkhateeb

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2189 | Submission Open

Keywords: genomics; computational biology; bioinformatics; machine learning; artificial intelligence (AI); next-generation sequencing (NGS); precision medicine; multi-omics integration; CRISPR-based engineering; single-cell genomics; ethical; legal; and social implications (ELSI); translational genomics; biomedical prediction models; network biology

(This special issue belongs to the Section Technologies and Resources for Genetics)

From Genetic Mechanisms Discovery to Patient-Centered Care: The Expanse of Genomics Research

edited by Kathleen D. Valverde and Deb A. Duquette

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2090 | Submission Open

Keywords: Genomic Medicine; Precision Medicine; Functional Genomics; Variant Interpretation; Genetic Mechanisms

(This special issue belongs to the Section Genetic Diagnosis)

AI and Machine Learning in Cancer Genomics

edited by

S M Ashiqul Islam

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1501 | Submission Open

Keywords: genomics; cancer; AI; ML; tools; signatures; biomarkers; oncology

(This special issue belongs to the Section Bioinformatics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Nov 2025 | 1 articles | Viewed by 722 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Emerging Topics in Population Genetics and Molecular Anthropology

edited by

Jelena Šarac

and Dubravka Havaš Auguštin

submission deadline 25 Nov 2025 | Viewed by 323 | Submission Open

Keywords: population genetics; molecular anthropology; archeogenetics; forensic genetics; impact of genetic diversity on human health; evolution; genome; phylogenetics

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

New Developments in Pediatric Clinical Genetics and Metabolic Diseases

edited by Laura L. Konczal and Chen-Han Wilfred Wu

submission deadline 25 Nov 2025 | Viewed by 223 | Submission Open

Keywords: inherited metabolic disease; gene therapy; CRISPR; mRNA; pediatric genetics; rare inherited disease; whole genome sequencing; diagnosis of rare disorders; treatment of rare disorders; newborn screening

(This special issue belongs to the Section Genetic Diagnosis)

Genetic and Genomic Innovations for Developing Resilient Crops

edited by

Huajin Sheng

and

Sheng Wang

submission deadline 25 Nov 2025 | Viewed by 218 | Submission Open

Keywords: crop improvement; abiotic stress; gene function; transcriptomics; gene editing; molecular breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Diagnosis and Treatment of Inherited Breast Cancer

edited by Maja Prutki and

Ivo Dumić-Čule

submission deadline 25 Nov 2025 | Viewed by 134 | Submission Open

Keywords: inherited breast cancer; germline mutations; BRCA1; BRCA2; genetic testing; risk assessment; preventive strategies; targeted therapy; personalized medicine; genetic counseling

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neurodevelopmental Disorders, Pathogenesis, and Precision Therapies

edited by Andrea L . Gropman

submission deadline 25 Nov 2025 | Viewed by 131 | Submission Open

Keywords: biochemical genetics; brain imaging; fNIRs; metabolism; child neurology; developmental disorders

(This special issue belongs to the Section Neurogenomics)

Genetic Mechanisms of Plant Resistance to Biotic Stress

edited by

Zhuo Chen

submission deadline 25 Nov 2025 | Viewed by 127 | Submission Open

Keywords: plant diseases; biotic stress; resistance genes; genetics; genomics; plant hosts

(This special issue belongs to the Section Plant Genetics and Genomics)

Host Genetics and Pathogens in One Health Context

edited by

Nathalie Bissonnette

submission deadline 25 Nov 2025 | Viewed by 119 | Submission Open

Keywords: One Health; farm animals; disease resistance; antimicrobial resistance

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Nerve Regeneration

edited by

Zhao-Qian Teng

and

Changmei Liu

submission deadline 25 Nov 2025 | Viewed by 100 | Submission Open

Keywords: nerve regeneration; neurodegeneration; neuroinflammation; metabolism; biomaterials; gene therapy; nerve repair; organoid

(This special issue belongs to the Section Neurogenomics)

The CranioFacial Biology Group at the University of Adelaide Collection: Genetic, Epigenetic and Environmental Factors in Complex Adaptive Systems, Multilayer Complex Interactive Networks, and Multiple Models During Oral Development

edited by

Alan H. Brook

and Matthew Brook O'Donnell

submission deadline 5 Dec 2025 | 2 articles | Viewed by 2680 | Submission Open

Keywords: oral development; genetics; epigenetics; complex adaptive systems; multilayer complex interactive networks; multiple models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuromuscular and Metabolic Diseases

edited by Micheal Palladino and

Claudia Ricci

submission deadline 5 Dec 2025 | 1 articles | Viewed by 1196 | Submission Open

Keywords: neurogenetics; metabolism; genetic models; biochemistry; therapy development; rare and ultra-rare genetic diseases

(This special issue belongs to the Section Neurogenomics)

Genes and Pediatrics

edited by

Giorgia Ceravolo

and

Roberto Chimenz

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1702 | Submission Open

Keywords: pediatric disease; genetic variant; clinical observation; diagnosis; patient care

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Biomarkers in Cancer: From Discovery to Clinical Application

edited by

Evangelos Koustas

submission deadline 10 Dec 2025 | 1 articles | Viewed by 876 | Submission Open

Keywords: cancer; tumor biology; biomarkers; cancer therapy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Insights into the Genomic and Genetic Basis of Cardiovascular Disease

edited by Marzia de Biasio and

Donato Gemmati

submission deadline 10 Dec 2025 | 1 articles | Viewed by 768 | Submission Open

Keywords: recurrent idiopathic pericarditis and perimyocarditis; spontaneous coronary dissection; sudden idiopathic cardiac death; idiopathic atrial fibrillation; cardio-oncology and cardio toxicity of anti anti-cancer drugs

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Genetics of Male Infertility and Clinical Implications

edited by

Gianmaria Salvio

submission deadline 10 Dec 2025 | Viewed by 392 | Submission Open

Keywords: genetics; male infertility; azoospermia; next generation sequencing; genetic variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Lung Diseases

edited by Jun Yang

submission deadline 10 Dec 2025 | Viewed by 180 | Submission Open

Keywords: lung diseases ; transcriptomics ; epigenetics ; gene– environment interaction ; functional genomics ; multi-omics integration

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Plant Genetics, Evolution, Cytogenetics and Cytogenomics for Biodiversity Conservation

edited by

Eric Javier Martínez

Ana Isabel Honfi

and

Anna Reutemann

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2056 | Submission Open

Keywords: plant conservation; cytogenetics; cytogenomics; plant evolution; population genetics; genome evolution; chromosomal variation; polyploidy; biodiversity; genomic resources

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Epidemiology of Parasites

edited by

Joanna Da̧browska

submission deadline 15 Dec 2025 | 1 articles | Viewed by 708 | Submission Open

Keywords: parasite genetics; parasite genomics; WGS; molecular epidemiology; zoonoses; virulence and pathogenesis; transmission dynamics; genetic diversity

(This special issue belongs to the Section Microbial Genetics and Genomics)

Molecular Genetics of Stress Response in Crops

edited by Jie Zhan

submission deadline 15 Dec 2025 | 1 articles | Viewed by 546 | Submission Open

Keywords: crop; abiotic stresses; protein translation; regulation; molecular mechanism; plant hormones

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Molecular Insights into Cardiovascular Disease: From Mechanisms to Precision Medicine

edited by

Lingfeng Luo

and

Laurent Metzinger

submission deadline 15 Dec 2025 | Viewed by 239 | Submission Open

Keywords: cardiovascular disease; genetic variants; precision medicine; epigenetics; non-coding RNAs; polygenic risk scores; mendelian randomization; biomarkers; genome-wide association studies (GWASs); molecular mechanisms

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Research on Molecular Mechanisms of DNA Damage

edited by

Judith Miné-Hattab

submission deadline 15 Dec 2025 | Viewed by 234 | Submission Open

Keywords: molecular and structure biology of DNA repair; chromatin dynamics during DNA repair; 3D genome organization in repair mechanisms; liquid– liquid phase separation; mechanobiology and DNA repair; inhibitors of DNA damage proteins for cancer therapy; link between DNA damage and neurological diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Cattle Genetics, Genomics and Breeding: From Molecular Insights to Sustainable Production

edited by

Hinayah Rojas De Oliveira

submission deadline 15 Dec 2025 | Viewed by 153 | Submission Open

Keywords: bovine; Bos taurus taurus; Bos taurus indicus; genomic selection; GWAS; multi-omics; gene editing; breeding strategies; reproductive technologies; genetic diversity; adaptation genetics; disease resistance; epigenetics; climate resilience; sustainable production; precision livestock farming

(This special issue belongs to the Section Animal Genetics and Genomics)

Application of Molecular or Genetic Markers in Liquid Biopsy for Urogenital Cancers

edited by

Guorong Li

submission deadline 15 Dec 2025 | Viewed by 105 | Submission Open

Keywords: liquid biopsy; extracellular vesicle; exosome; biotechnology; precision medicine/personalized medicine; diagnosis/screening; urogenital cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Feature Papers in Microbial Genetics and Genomics

edited by

Jose María Requena

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4022 | Submission Open

Keywords: virus; bacteria; protists; parasites; genomics; transcriptomics; proteomics; genetics; drug resistance; molecular evolution; data re-analysis

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic and Functional Genomics Insights into the Genetic Improvement of Stress Resistance in Economic Crops

edited by

Mingku Zhu

and Xiaoqing Meng

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3338 | Submission Open

Keywords: economic crops; functional genomics; molecular biology; genetic improvement; agricultural biotechnology

(This special issue belongs to the Section Plant Genetics and Genomics)

Novel Biomarkers of Neurodegenerative Diseases

edited by Arash Salardini

submission deadline 20 Dec 2025 | Viewed by 353 | Submission Open

Keywords: neurodegenerative diseases; biomarker discovery; Alzheimer's disease; Parkinson's disease; precision medicine; machine learning

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pediatric Neurology and Genetics

edited by

Roberta Milone

, Agatino Battaglia and Alberto Danieli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 329 | Submission Open

Keywords: rare neurological diseases; genomics; next-generation sequencing; cytogenetics; child neurology

(This special issue belongs to the Section Neurogenomics)

Epigenetics and Multiple Sclerosis

edited by Lara Kular and

Sudheer Kumar Gara

submission deadline 20 Dec 2025 | Viewed by 301 | Submission Open

Keywords: epigenetics; multiple sclerosis; DNA methylation; histone posttranslational modifications; non-coding RNAs

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Genetics of Skeletal Development

edited by André M Travessa,

Zhousheng Xiao

and

Dragan Primorac

submission deadline 20 Dec 2025 | Viewed by 238 | Submission Open

Keywords: skeletal development; skeletal dysplasias; clinical genetics; human genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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