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Advances in Cattle Genetics, Genomics and Breeding: From Molecular Insights to Sustainable Production

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: 15 May 2026 | Viewed by 647

Special Issue Editor


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Guest Editor
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
Interests: animal breeding; genetic analysis; livestock; longitudinal traits; genotyping; computational biology

Special Issue Information

Dear Colleagues,

This Special Issue focuses on recent advances and emerging technologies in cattle genomics and breeding across all bovine species, including Bos taurus taurus, Bos taurus indicus, and their crosses. We welcome contributions that explore the fundamental molecular mechanisms underlying economically important traits and applied research demonstrating innovative breeding strategies. Topics of interest include but are not limited to genomic selection methodologies, genome-wide association studies, genome-editing applications, multi-omics approaches (genomics, transcriptomics, proteomics, and metabolomics), reproductive technologies, genetic diversity assessments, adaptation genetics, disease resistance, and epigenetic regulation in cattle. We particularly encourage submissions that address integrating novel technologies with traditional breeding practices, climate resilience and adaptation strategies, and sustainable production systems. This Special Issue aims to provide a comprehensive overview of current future directions in cattle genomics research, serving as a valuable resource for researchers, breeders, and industry stakeholders working to advance bovine genetics and genomics for improved productivity, welfare, and sustainability.

Dr. Hinayah Rojas De Oliveira
Guest Editor

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Keywords

  • bovine
  • Bos taurus taurus
  • Bos taurus indicus
  • genomic selection
  • GWAS
  • multi-omics
  • gene editing
  • breeding strategies
  • reproductive technologies
  • genetic diversity
  • adaptation genetics
  • disease resistance
  • epigenetics
  • climate resilience
  • sustainable production
  • precision livestock farming

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Published Papers (1 paper)

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Research

10 pages, 1354 KB  
Article
Study on the Developmental Differences Between Female and Male Early Embryos in Cattle In Vivo
by Jie Wang, Fei Huang, Di Fang, Peng Niu, Jie-Ru Wang and Qing-Hua Gao
Genes 2025, 16(12), 1485; https://doi.org/10.3390/genes16121485 - 11 Dec 2025
Viewed by 302
Abstract
Background: The developmental differences between female and male early embryos regarding sex development remain a topic of controversy. Objectives: This study aims to investigate whether there are significant developmental differences between female and male bovine embryos during in vivo development. Methods: The CIDR [...] Read more.
Background: The developmental differences between female and male early embryos regarding sex development remain a topic of controversy. Objectives: This study aims to investigate whether there are significant developmental differences between female and male bovine embryos during in vivo development. Methods: The CIDR + FSH + PGF2α + GnRH method was employed to induce superovulation in 20 donor cows. Subsequently, artificial insemination was performed on the donor cows using high-purity X and Y frozen semen, with 10 cows receiving each type of semen. Seven days later, the embryos were flushed from the donor cows. The flushed embryos underwent embryonic sex determination, followed by immunofluorescence analysis to observe proliferation and apoptosis, and finally, RT-PCR was conducted to detect genes associated with proliferation and apoptosis. Results: The results indicated that the sex ratio of embryos obtained through artificial insemination using X/Y semen did not significantly differ based on semen purity (p ≥ 0.05). However, the fluorescence intensity of apoptotic cells in the X-BL group was significantly higher than that in the Y-BL group (p < 0.05). Conversely, the fluorescence intensity of proliferating cells in the X-BL group was significantly lower than that in the Y-BL group (p < 0.05). Furthermore, the expression levels of apoptosis-related genes in the X-BL group were significantly higher compared to the Y-BL group (p < 0.05), while the expression levels of proliferation-related genes in the X-BL group were significantly lower than those in the Y-BL group (p < 0.01). Conclusions: The above results indicate that during in vivo development of bovine early embryos, male embryos develop at a faster rate than female embryos. Full article
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