Epigenetics and Multiple Sclerosis
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 8
Special Issue Editors
Interests: epigenetics; functional genomics; multiple sclerosis; neuroinflammation; neurodegeneration
Special Issue Information
Dear Colleagues,
Multiple Sclerosis (MS) is a chronic neuroinflammatory, demyelinating, and neurodegenerative disease of the central nervous system, and a leading cause of lifelong progressive disability in young and middle-aged adults. Notably, the disease is highly heterogenous, symptoms vary greatly depending on the location of the lesion and progression, and the severity is often hard to predict and detect. MS disease is triggered by environmental factors in genetically predisposed individuals. Epigenetic mechanisms like DNA methylation, histone posttranslational modification, and non-coding RNA levels, are sensitive to environmental/lifestyle exposures and regulate gene expression and cellular function without affecting the DNA sequence. Epigenetic studies have the potential to reveal how environmental and genetic factors interact to influence disease onset and progression and to provide valuable insights into novel biomarkers for better patient stratification and personalized medicine.
This Special Issue welcomes original research, reviews, and systematic reviews that focus on recent advances related to the function, mechanisms, biomarker potential, and clinical application implications of epigenetics in Multiple Sclerosis.
Dr. Lara Kular
Dr. Sudheer Kumar Gara
Guest Editors
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Keywords
- epigenetics
- multiple sclerosis
- DNA methylation
- histone posttranslational modifications
- non-coding RNAs
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