Host Genetics and Pathogens in One Health Context
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 3
Special Issue Editor
Special Issue Information
Dear Colleagues,
For this Special Issue, we aim to highlight the contribution of agricultural research—particularly in farm animals and environmental studies—to advance our understanding of host–pathogen interactions and disease resistance within the framework of the One Health approach.
The One Health concept is an integrated strategy that recognizes the interdependence of humans, animals, and environmental health. This approach is especially relevant in the context of emerging infectious diseases, of which approximately 60% are zoonotic in origin.
To address disease control comprehensively, various strategies are being explored, including prevention, reduction in antibiotic resistance, and enhancement of natural immunity. While the innate immune system is largely conserved across species, significant differences exist in the structure of pathogen-recognition receptors. Unlike laboratory animals such as mice, farm animals have not been subjected to the same selective pressures, making them more representative models for studying innate immunity relevant to human health.
Species such as cattle, pigs, and chickens serve as valuable models for investigating disease resistance and susceptibility. They have also contributed significantly to our understanding of developmental immunology and vaccine development in humans.
In this Special Issue, we present recent multidisciplinary research that elucidates the molecular mechanisms underlying host–pathogen interactions and explores the complex environmental factors influencing global health security. These insights are essential for enhancing our preparedness and response to current and future health threats.
Dr. Nathalie Bissonnette
Guest Editor
Manuscript Submission Information
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Keywords
- One Health
- farm animals
- disease resistance
- antimicrobial resistance
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