Genetics and Genomics of Lung Diseases

Dear Colleagues,

Lung diseases represent a major cause of morbidity and mortality worldwide, underlining the need to unravel their genetic and genomic underpinnings to improve their diagnosis and treatment. Some lung disorders are driven by rare high-impact mutations (e.g., the monogenic defect in cystic fibrosis), whereas others, such as asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF), involve the complex contribution of numerous common genetic variants—often identified through genome-wide association studies (GWAS) and exome sequencing—together with environmental risk factors. Rapid advances in high-throughput sequencing, single-cell and spatial transcriptomics, and other genomic technologies are shedding light on the molecular pathways driving lung disease pathogenesis and revealing novel targets for therapy.

This Special Issue welcomes high-quality, cutting-edge research on GWAS and rare-variant analyses, single-cell and spatial transcriptomic profiling, epigenetic regulation, gene–environment interactions, functional genomics, and integrative multi-omics approaches. We especially welcome studies that deepen our understanding of the genetic architecture of lung diseases and translate these findings into precision medicine strategies. By assembling such contributions, our goal is to highlight the molecular mechanisms underlying lung diseases such as asthma, COPD, IPF, cystic fibrosis, and lung cancer, ultimately paving the way for improved personalized diagnostics and therapies.

Dr. Jun Yang
Guest Editor

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