Novel Biomarkers of Neurodegenerative Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 1 April 2026 | Viewed by 1011
Special Issue Editor
Interests: neurodegenerative diseases; biomarker discovery; Alzheimer's disease; neuroinflammation; precision medicine
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases represent one of the most pressing medical challenges of our time, affecting millions worldwide and imposing enormous burdens on patients, families, and healthcare systems. The rising prevalence of conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis underscores the urgent need for early detection, accurate diagnosis, and effective monitoring strategies. Central to addressing these challenges is the identification and validation of genetic biomarkers that can transform our approach to neurodegenerative disease management through precision medicine approaches.
This Special Issue aims to showcase cutting-edge research in the discovery, development, and clinical application of genetic biomarkers for neurodegenerative diseases, with a particular focus on those enabling earlier diagnosis, differential diagnosis, risk stratification, and the monitoring of disease progression. We invite submissions that explore diverse genetic biomarker approaches, including polygenic risk scores and their clinical implementation, rare variant discovery and functional validation, gene expression signatures and transcriptomic biomarkers, epigenetic modifications (DNA methylation, histone modifications, and non-coding RNAs), pharmacogenomic markers for treatment response prediction, and multi-omics integration that incorporates genetic data with proteomic, metabolomic, and neuroimaging findings to enhance diagnostic accuracy and prognostic value.
Of particular interest are studies that demonstrate translational potential, moving from genetic discoveries to clinical applications, including validation in diverse populations, consideration of genetic ancestry and population stratification, assessment of scalability and cost-effectiveness of genetic testing platforms, and evaluation of potential pathways to regulatory approval. We also welcome research on gene–environment interactions, genetic modifiers of disease penetrance and progression, and novel computational approaches for genetic biomarker discovery and validation in neurodegenerative diseases.
Dr. Arash Salardini
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegenerative diseases
- biomarker discovery
- Alzheimer's disease
- Parkinson's disease
- precision medicine
- machine learning
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