Novel Biomarkers of Neurodegenerative Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 70
Special Issue Editor
Interests: neurodegenerative diseases; biomarker discovery; Alzheimer's disease; neuroinflammation; precision medicine
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases represent one of the most pressing medical challenges of our time, affecting millions worldwide and imposing enormous burdens on patients, families, and healthcare systems. The rising prevalence of conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis underscores the urgent need for early detection, accurate diagnosis, and effective monitoring strategies. Central to addressing these challenges is the identification and validation of genetic biomarkers that can transform our approach to neurodegenerative disease management through precision medicine approaches.
This Special Issue aims to showcase cutting-edge research in the discovery, development, and clinical application of genetic biomarkers for neurodegenerative diseases, with a particular focus on those enabling earlier diagnosis, differential diagnosis, risk stratification, and the monitoring of disease progression. We invite submissions that explore diverse genetic biomarker approaches, including polygenic risk scores and their clinical implementation, rare variant discovery and functional validation, gene expression signatures and transcriptomic biomarkers, epigenetic modifications (DNA methylation, histone modifications, and non-coding RNAs), pharmacogenomic markers for treatment response prediction, and multi-omics integration that incorporates genetic data with proteomic, metabolomic, and neuroimaging findings to enhance diagnostic accuracy and prognostic value.
Of particular interest are studies that demonstrate translational potential, moving from genetic discoveries to clinical applications, including validation in diverse populations, consideration of genetic ancestry and population stratification, assessment of scalability and cost-effectiveness of genetic testing platforms, and evaluation of potential pathways to regulatory approval. We also welcome research on gene–environment interactions, genetic modifiers of disease penetrance and progression, and novel computational approaches for genetic biomarker discovery and validation in neurodegenerative diseases.
Dr. Arash Salardini
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegenerative diseases
- biomarker discovery
- Alzheimer's disease
- Parkinson's disease
- precision medicine
- machine learning
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
