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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics in Headache and Neurogenic Pain

edited by Yohannes W. Woldeamanuel and Xianghong Arakaki

submission deadline 25 Feb 2026 | Viewed by 207 | Submission Open

Keywords: genetics; headache; neurogenic pain; migraine; genomics; epigenetics; polygenic risk; biomarkers; precision medicine; CRISPR; neuropathic pain; gene– environment interactions; translational research; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Neurogenomics)

Unraveling the Genetic Tapestry of Human Populations: New Insights from Population Genetics and Identification in Anthropology

edited by

Lovorka Barać Lauc

submission deadline 25 Feb 2026 | Viewed by 184 | Submission Open

Keywords: human genetic diversity; population genetics; migration patterns; admixture; isolated populations; ancestry reconstruction; anthropological genomics; biomedical relevance; forensic identification

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genomics and Gene Expression of the Oral Microbiome

edited by

Johan Samot

and

Mahmoud Rouabhia

submission deadline 25 Feb 2026 | Viewed by 145 | Submission Open

Keywords: oral microbiome; gene expression regulation; metagenomics; transcriptome; horizontal gene transfer; antimicrobial resistance; biofilms; bacteriophages; virulence factors

(This special issue belongs to the Section Microbial Genetics and Genomics)

Driver Genes in Prostate Carcinogenesis and Resistance to Treatment

edited by

Daotai Nie

submission deadline 25 Feb 2026 | Viewed by 97 | Submission Open

Keywords: genomic instability; driver genes; prostate cancer prevention; castration therapy; drug resistance

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding of Tea Tree and Tea Plant

edited by Lianyu Yuan

submission deadline 25 Feb 2026 | Viewed by 88 | Submission Open

Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant

(This special issue belongs to the Section Plant Genetics and Genomics)

Research on Genetics and Breeding of Cattle

edited by

Borhan Shokrollahi

submission deadline 5 Mar 2026 | 3 articles | Viewed by 3093 | Submission Open

Keywords: reproductive genetics and biotechnology; biotechnology in cattle; genomic selection; marker-assisted breeding; genetic diversity; assisted reproductive technologies; molecular genetics; fertility and reproduction; cattle breeding strategies; epigenetics

(This special issue belongs to the Section Animal Genetics and Genomics)

AI and Neurogenomics: Innovations in Precision Medicine for Brain Disorders

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 5 Mar 2026 | 2 articles | Viewed by 1748 | Submission Open

Keywords: neurogenetics; genomics; artificial intelligence; brain disorders; neurodegenerative disease

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Profiling and Molecular Analysis in Autism Spectrum Disorders

edited by John Jay Gargus

submission deadline 5 Mar 2026 | Viewed by 173 | Submission Open

Keywords: whole-exome and genome sequencing in ASD; functional genomics of high-confidence ASD risk genes; transcriptomics and splicing variants in the autistic brain; calcium signaling and ion channelopathies; chromatin and epigenetic dysregulation in ASD; mitochondrial dysfunction and oxidative stress; immune– neural signaling cross-talk; systemic extracerebral traits associated with ASD; stratification of ASD subtypes; sex-biased molecular mechanisms in ASD; integrative omics for therapeutic target discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Endocrine Diseases in Children and Adolescents

edited by

Malgorzata Wasniewska

submission deadline 10 Mar 2026 | 2 articles | Viewed by 3750 | Submission Open

Keywords: endocrine disease; endocrine gland; genetic syndrome; genetic polymorphism; genetic pathomechanism

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Basis in Rare Genetic Disorders

edited by

Miao Sun

submission deadline 10 Mar 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: nucleotide and mitochondrial DNA; RNA modification; epigenetics; gene expression; rare disease and inheritance; clinical pathology; disease mechanism; bioinformatics and tools; functional studies; treatment and therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Prenatal and Postnatal Genetic Testing: Precision Diagnosis for Genetic Disorders

edited by

Spiros Vittas

and Eirini Louizou

submission deadline 10 Mar 2026 | Viewed by 433 | Submission Open

Keywords: genetic testing; prenatal diagnosis; postnatal diagnosis; precision medicine

(This special issue belongs to the Section Genetic Diagnosis)

Reviews in RNA: Mechanisms and Roles

edited by

Laurent Metzinger

and

Valérie Metzinger-Le Meuth

submission deadline 10 Mar 2026 | Viewed by 305 | Submission Open

Keywords: gene regulation; non-coding RNA; RNA world; RNA-related metabolism

(This special issue belongs to the Section RNA)

Genetic Insights into Immunity and Pathogen Resistance

edited by

Fabiana Neves

and Tereza Almeida

submission deadline 10 Mar 2026 | Viewed by 190 | Submission Open

Keywords: immunogenetics; host– pathogen coevolution; genetic variation; functional genomics; comparative immunology; CRISPR; pathogen resistance; evolutionary immunology; epigenetics; genome-wide association studies (GWASs)

(This special issue belongs to the Section Molecular Genetics and Genomics)

Precision Genome Engineering in Plants

edited by

Weibin Song

and Zhiyong Zhang

submission deadline 10 Mar 2026 | Viewed by 75 | Submission Open

Keywords: CRISPR-Cas9; genome editing; base editing; prime editing; crop improvement; gene targeting; synthetic biology; plant biotechnology; off-target effects; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Physiological and Molecular Mechanisms of Plant Stress Response

edited by

Yakupjan Haxim

submission deadline 15 Mar 2026 | 3 articles | Viewed by 2002 | Submission Open

Keywords: drought stress; heat stress; cold stress; salinity stress; pathogen infection; multi-omic approaches; gene expression; plant resistance

(This special issue belongs to the Section Plant Genetics and Genomics)

Epigenetic Regulation in Tumors

edited by

Anca Botezatu

submission deadline 15 Mar 2026 | Viewed by 1087 | Submission Open

Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics

(This special issue belongs to the Section Epigenomics)

Unveiling Human Microbiome Composition and Functions to Improve Health and Disease Research

edited by

Valeria D’Argenio

submission deadline 15 Mar 2026 | Viewed by 383 | Submission Open

Keywords: human microbiome; health and disease; precision medicine; host– microbe interactions; translational research; metagenomics; multi-omics approaches

(This special issue belongs to the Section Microbial Genetics and Genomics)

Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture

edited by Samathmika Ravi,

Maria Cristina Della Lucia

and

Piergiorgio Stevanato

submission deadline 15 Mar 2026 | Viewed by 326 | Submission Open

Keywords: multi-omics; plant– microbe interactions; climate resilience; agricultural sustainability; microbial dynamics

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics of Host–Pathogen Interactions

edited by

Transito Garcia-Garcia

and Sara Zaldívar López

submission deadline 15 Mar 2026 | Viewed by 313 | Submission Open

Keywords: pathogen virulence factors; infection susceptibility; immune evasion; genomics of infectious diseases; host– pathogen co-evolution; host– pathogen dynamics; microbiome– host interactions; emerging infectious diseases; crispr and gene editing in host– pathogen studies; transcriptomics and gene expression profiling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Dynamics in Cancer and Aging

edited by

Hayan Lee

submission deadline 15 Mar 2026 | Viewed by 296 | Submission Open

Keywords: DNA methylation; histone modification; chromatin 3D modeling; non-coding RNA; long-read sequencing technology; single-cell epigenetics; cancer initiation and development; epigenetic alterations in the aging process; aging-specific epigenetic alterations; cancer-specific epigenetic alterations

(This special issue belongs to the Section Epigenomics)

Genetic Markers in Targeted Therapies: From Biomarker Discovery to Personalized Therapy

edited by

Maciej Wnuk

submission deadline 15 Mar 2026 | Viewed by 172 | Submission Open

Keywords: cancer diagnosis; molecular; cytogenetic biomarkers; genomic instability; cellular senescence; human disease; clinical applications; personalized therapy; theranostics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Landscape of Neurodevelopmental Disorders

edited by Bimal Jana

submission deadline 15 Mar 2026 | Viewed by 78 | Submission Open

Keywords: epigenetics; neurodevelopmental disorders (NDDs); DNA methylation; 3D genome architecture; histone modifications; non-coding RNA; autism spectrum disorder (ASD); Rett syndrome; neurodevelopment; gene-environment interaction; epigenetic biomarkers; single-cell epigenomics; epigenetic therapy

(This special issue belongs to the Section Neurogenomics)

Cancer Epigenetics: From Laboratory Studies and Clinical Trials to Precision Medicine

edited by Rajendra Pangeni

submission deadline 15 Mar 2026 | Viewed by 70 | Submission Open

Keywords: cancer; epigenetics; laboratory studies; tumor biology; precision medicine; clinical trials; therapy resistance; biomarkers; personalized care; therapeutic interventions

(This special issue belongs to the Section Epigenomics)

Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 16 Mar 2026 | 1 articles | Viewed by 607 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

RNA Biology and Diseases

edited by Sharon Moshitch-Moshkovitz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 561 | Submission Open

Keywords: mechanisms of RNA processing; RNA modification and epitranscriptomics; regulatory RNAs; RNA-based therapy (ASOs; targeted modifications); RNA– protein interactions; non-coding RNAs and diseases; post-translational modifications in shaping the epitranscriptome; RNA structures and restructuring mechanisms

(This special issue belongs to the Section RNA)

Genetic Diagnosis and Genomics of Neurological Diseases

edited by

Avi Fellner

and Penina Ponger

submission deadline 20 Mar 2026 | Viewed by 344 | Submission Open

Keywords: neurogenetics; hereditary neurological diseases; genetic diagnosis; genotype– phenotype correlation; next-generation sequencing; precision neurology; clinical genomics; diagnostic yield; genomic technologies; data-driven approaches

(This special issue belongs to the Section Genetic Diagnosis)

The Regulation of mRNA Translation in Health and Disease

edited by Jun Ling

submission deadline 20 Mar 2026 | Viewed by 343 | Submission Open

Keywords: mRNA translation; mRNA biology; transcriptional regulation; cell signaling; cancer therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mouse Models of Human Disease

edited by Jiale Wang

submission deadline 20 Mar 2026 | Viewed by 284 | Submission Open

Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Non-Coding RNA in Cancer

edited by Amil M. Shah

submission deadline 20 Mar 2026 | Viewed by 207 | Submission Open

Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq; spatial transcriptomics; and single-cell multi-omics)

(This special issue belongs to the Section RNA)

Canine Genomics and Disease Research

edited by

Jeffrey Kidd

submission deadline 20 Mar 2026 | Viewed by 182 | Submission Open

Keywords: canine genetics; trait mapping; genome structure and function; population genetics; association studies; canine evolution; canine disease

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Reproduction in Pigs

edited by Rui Cai

submission deadline 20 Mar 2026 | Viewed by 155 | Submission Open

Keywords: pig; spermatogenesis; semen preservation; reproductive technology; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Machine Learning in Cancer and Disease Genomics

edited by

Piero Fariselli

and Giovanni Birolo

submission deadline 25 Mar 2026 | 6 articles | Viewed by 17135 | Submission Open

Keywords: machine learning; cancer genomics; disease genomics; bioinformatics; genomic data analysis; biomarker discovery; multi-omics integration; personalized medicine; computational biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Insects

edited by Hui Ai

submission deadline 25 Mar 2026 | 2 articles | Viewed by 912 | Submission Open

Keywords: insect molecular biology; genomics; molecular systematics; transcriptomics; genetic; genomic; pest management strategies; gene function; insect chemical ecology

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Epigenetics of Cellular Differentiation

edited by

Theodora Sideri

submission deadline 25 Mar 2026 | Viewed by 788 | Submission Open

Keywords: stem cells; differentiation; gene expression; genetics; histone modifications; DNA methylation

(This special issue belongs to the Section Epigenomics)

Utilizing Multi-Omics to Investigate Neurodegenerative Disorders

edited by Muhammad Ali

submission deadline 25 Mar 2026 | Viewed by 500 | Submission Open

Keywords: neurodegeneration; central nervous system; diagnosis; prognosis; biomarkers; predictive modeling; brain; cerebrospinal fluid; plasma; multi-omics

(This special issue belongs to the Section Neurogenomics)

Mitochondrial Genetics: Progress and Challenges

edited by

Konstantin Khrapko

submission deadline 25 Mar 2026 | Viewed by 353 | Submission Open

Keywords: Mitochondria; ; mtDNA; ; mutation; ; selection; ; germline; ; mitchondrial disease; ; inheritance; ; population; ; evolution; ; NUMT

(This special issue belongs to the Section Molecular Genetics and Genomics)

Livestock Germplasm Resources, Genetics, and Breeding

edited by

Enrico D’ Alessandro

and Marco Tolone

submission deadline 25 Mar 2026 | Viewed by 313 | Submission Open

Keywords: animal genetics; genomics; animal production; metagenomics; genome-wide association study (GWAS); product quality; fertility; health; coat color; molecular traceability; biodiversity

(This special issue belongs to the Section Animal Genetics and Genomics)

Reviews in Aquaculture Genetics: Insights and Advances

edited by

Antonio Figueras

Beatriz Novoa

, Magali Rey-Campos and

Amaro Saco

submission deadline 25 Mar 2026 | Viewed by 249 | Submission Open

Keywords: aquaculture genetics; fish genomics; shellfish breeding; quantitative trait loci; marker-assisted selection; genomic selection; transcriptomics; epigenomics; disease resistance; growth traits; aquatic species; genome assembly; population genomics; selective breeding; sustainable aquaculture

(This special issue belongs to the Section Animal Genetics and Genomics)

The Genetic Lens: A New Era in Ophthalmology

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 25 Mar 2026 | Viewed by 184 | Submission Open

Keywords: ophthalmology; genomics; artificial intelligence; inherited retinal disease; blindness

(This special issue belongs to the Section Genetic Diagnosis)

Genetic Mechanisms of Obesity

edited by

Thangiah Geetha

submission deadline 25 Mar 2026 | Viewed by 168 | Submission Open

Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene– environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 25 Mar 2026 | Viewed by 132 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 25 Mar 2026 | Viewed by 65 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Genomics of Aging and Longevity, Pathways and Response to Nutrients in Mammals and Simple Model Organisms

edited by

Mario G. Mirisola

submission deadline 30 Mar 2026 | Viewed by 216 | Submission Open

Keywords: nutrigenetics; nutrigenomics; signal transduction

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Application of CRISPR/Cas9 Technology in Insects

edited by

Sanyuan Ma

submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open

Keywords: genome editing; gene targeting; CRISPR/Cas9; insect genetics; pest control; disease vector control; gene drive; off-target effects; delivery systems; ecological impact; transgenic insects; functional genomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Novel Biomarkers of Neurodegenerative Diseases

edited by Arash Salardini

submission deadline 1 Apr 2026 | 1 articles | Viewed by 405 | Submission Open

Keywords: neurodegenerative diseases; biomarker discovery; Alzheimer's disease; Parkinson's disease; precision medicine; machine learning

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuropsychiatric Disorders

edited by Melloni Cook and Kristin Hamre

submission deadline 5 Apr 2026 | 7 articles | Viewed by 8902 | Submission Open

Keywords: major depressive disorder; schizophrenia; post-traumatic stress disorder; addiction; alcohol; drugs; anxiety disorder; stress-related disorders; genes; epigenetics; mRNA; optogenetics; miRNA; causal variant

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genes and Gene Therapies in Chronic Renal Disease

edited by Thomas Kitzler

submission deadline 5 Apr 2026 | 3 articles | Viewed by 5246 | Submission Open

Keywords: chronic renal disease; personalized medicine; exome and genome sequencing; nephrogenetics; genetic kidney disease; small molecules; mRNA therapies; gene editing; gene delivery

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 5 Apr 2026 | 1 articles | Viewed by 1382 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Conservation Genetics of Birds

edited by Robert Rutkowski

submission deadline 6 Apr 2026 | Viewed by 157 | Submission Open

Keywords: conservation genetics; birds; aves; endangered species; molecular markers; genetic diversity; genetic distance; isolated populations; non-invasive sampling; genetic monitoring; reintroduction; inbreeding; outbreeding; evolutionary significant units; management unit

(This special issue belongs to the Section Animal Genetics and Genomics)

Next-Generation Sequencing in Rare Genetic Diseases

edited by

Edoardo Errichiello

and

Paola Dimartino

submission deadline 10 Apr 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: rare genetic diseases; next-generation sequencing; bioinformatics; multiomics data; artificial intelligence; gene discovery; single nucleotide variants; structural variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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