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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Diagnosis and Management of Liver Diseases

edited by

Jiang Liu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1661 | Submission Open

Keywords: primary liver cancer; metastatic liver cancer; liver transplantation; diagnosis; prognosis; biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic and Operative Hysteroscopy, 2nd Edition

edited by

Panagiotis Christopoulos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1650 | Submission Open

Keywords: hysteroscopy; diagnosis; technique; malformation; uterus; endometrial; anomaly; minimally invasive; pathology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Autoimmune Diseases

edited by

Micol Romano

and

Dimitri Poddighe

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1642 | Submission Open

Keywords: autoimmunity; autoinflammatory diseases; rheumatology; innovative and biological therapies; comorbidity; immune-mediated manifestations

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Molecular Diagnostics in Cardiovascular Diseases: From Biomarkers to Individualized Medicine

edited by

Priyanka Gokulnath

and

Michail Spanos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1597 | Submission Open

Keywords: molecular diagnostics; cardiovascular diseases; biomarkers; individualized medicine; precision cardiology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Inflammatory Pathways and Diagnostic Strategies in Chronic Diseases

edited by

Liliana-Georgeta Foia

Maria Alexandra Mârțu

and

Minerva Codruta Badescu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1570 | Submission Open

Keywords: chronic diseases; early diagnosis; non-invasive diagnosis; artificial intelligence application

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

A New Era in Diagnosis: From Biomarkers to Artificial Intelligence, 2nd Edition

edited by

Tudor Drugan

and

Daniel Leucuta

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1513 | Submission Open

Keywords: biomarkers; diagnosis; personalized medicine; therapeutic strategies; artificial intelligence; machine learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advancements in Maternal–Fetal Medicine: 3rd Edition

edited by

Elena Bernad

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1504 | Submission Open

Keywords: maternal–fetal medicine; high-risk pregnancy; prenatal diagnostics; psychological distress in pregnancy; anxiety and depression; stress-related disorders; biomarkers; perinatal morbidity and mortality; translational diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Chronic Kidney Diseases: Diagnosis, Management, and Prognosis

edited by

Xujie Zhou

submission deadline 31 Dec 2026 | Viewed by 1496 | Submission Open

Keywords: chronic kidney diseases; IgA nephropathy; biomarkers; molecular mechanisms; therapeutic innovation; personalized medicine; translational research

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Sarcoma Diagnostics: Histopathology, Imaging, and Artificial Intelligence for Precision Management

edited by

Siu Wai Choi

submission deadline 31 Dec 2026 | Viewed by 1324 | Submission Open

Keywords: sarcoma diagnosis and prognosis; machine learning models; genomics in diagnosis; classification and prognosis; novel methods of treatment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Prognostic and Predictive Biomarkers, 4th Edition

edited by

Yuli Huang

and

Peisong Chen

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1308 | Submission Open

Keywords: biomarkers; prognostic; predictive; risk stratification; cardiovascular disease; diabetes; cancer; hypertension; heart failure

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances in Oral and Maxillofacial Surgery: Diagnosis and Management

edited by Kenji Yamagata

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1281 | Submission Open

Keywords: oral and maxillofacial surgery; oral diseases; oral cancer; jaw deformity; orthognathic surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Women’s Cardiovascular Health: Advances in Diagnosis, Screening, and Risk Prediction

edited by

Jasjit S. Suri

and

Luca Saba

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1241 | Submission Open

Keywords: artificial intelligence; women’s cardiovascular health; diagnosis; screening; risk prediction

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Whole-Body PET/CT: From Diagnosis to Prognosis

edited by Ioannis M. Tsougos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1229 | Submission Open

Keywords: whole-body PET/CT; diagnosis; prognosis; human diseases; medical imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Update on Diagnosis in Cardiovascular Interventions

edited by

Alfredo E. Rodriguez

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1217 | Submission Open

Keywords: myocardial infarction; stents; coronary artery disease; drugs; coronary imaging; structural heart disease; meta-analysis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advanced Ultrasound Techniques in Diagnosis, Second Edition

edited by

Laith Riyadh Sultan

submission deadline 31 Dec 2026 | Viewed by 1197 | Submission Open

Keywords: super-resolution imaging; microvascular imaging (MVI); contrast-enhanced ultrasound; AI-guided ultrasound; quantitative analysis; diagnostic imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Fetal Diagnosis and Therapy: 2nd Edition

edited by Elisa Montaguti and Camilla Dionisi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1195 | Submission Open

Keywords: ultrasound; prenatal diagnosis; NIPT; fetal echocardiography; fetal therapy; fetal MRI

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Autoimmune Rheumatic Diseases

edited by

Liangjing Lu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1147 | Submission Open

Keywords: autoimmune rheumatic diseases; biomarkers; precision medicine; targeted therapy; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Advances in Orthodontics and Dentistry

edited by

Antonino Lo Giudice

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1041 | Submission Open

Keywords: CBCT facial scanning; oral imaging; orthodontics; digital dentistry; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Eye Disease, Fifth Edition

edited by

Jae-Ho Han

submission deadline 31 Dec 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: medical diagnosis; artificial intelligence; deep learning; fundus image; optical coherence tomography; ophthalmology; retinal vessel; glaucoma; retinopathy; macular degeneration; image segmentation

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Prostate Cancer: Innovations in Diagnosis and Risk Stratification

edited by Biren Saraiya

submission deadline 31 Dec 2026 | 1 articles | Viewed by 932 | Submission Open

Keywords: prostate cancer; diagnostics; therapeutics; molecular targets; Prostate Specific Membrane Antigen (PSMA); risk stratification; radioligand therapy; multimodal therapy; clinical guidelines

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Emerging Technologies for Lung Disease Detection and Clinical Assessment

edited by Scott Matson and

Joshua Jay Reicher

submission deadline 31 Dec 2026 | 1 articles | Viewed by 746 | Submission Open

Keywords: medical imaging; artificial intelligence (AI); radiology; machine learning (ML)

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Cancer Diagnosis and Intervention

edited by Vlad Alexandru Gâta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 588 | Submission Open

Keywords: diagnostic; precision oncology; artificial intelligence; radiomics; molecular biomarkers; interventional oncology; personalized medicine; translational research

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Accurate Diagnosis and Management of Infectious and Respiratory Diseases

edited by

Marco Goeijenbier

submission deadline 31 Dec 2026 | 1 articles | Viewed by 560 | Submission Open

Keywords: infectious and respiratory diseases; viral and bacterial pathogens; multiplex molecular panels; rapid diagnostic tests; intensive care units

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in the Laboratory Diagnosis—2nd Edition

edited by

Giuseppe Lippi

and Camilla Mattiuzzi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 544 | Submission Open

Keywords: laboratory diagnosis; biomarkers; clinical chemistry; laboratory analysis; artificial intelligence

(This special issue belongs to the Section Clinical Laboratory Medicine)

Emerging Diagnostic Techniques and Therapeutic Strategies in Urological Oncology

edited by

Francesco Chierigo

submission deadline 31 Dec 2026 | Viewed by 529 | Submission Open

Keywords: prostate cancer; screening; biomarkers; genetic testing; imaging; PSMA; artificial intelligence; radical prostatectomy; radiotherapy; hormonal therapies

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

From Early Diagnosis to Therapy Response: Machine Learning Driven Biomarker Discovery

edited by Wenjie Shi and Rudy Leon De Wilde

submission deadline 31 Dec 2026 | 1 articles | Viewed by 523 | Submission Open

Keywords: machine learning; biomarker discovery; early diagnosis; liquid biopsy; precision medicine

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Artificial Intelligence in Epidemiological Diagnostics: Advances and Applications

edited by

Jinhui Tian

submission deadline 31 Dec 2026 | Viewed by 515 | Submission Open

Keywords: artificial intelligence in diagnostic epidemiology; machine learning for diagnostic screening; predictive diagnostic modeling; automated diagnostic evidence synthesis; AI-designed peptides for diagnostics; antimicrobial peptide diagnostics; AI peptide engineering for pathogen detection; AI-driven population health diagnostics; diagnostic health informatics; digital diagnostic epidemiology

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in the Diagnosis, Prognosis, and Management of the Musculoskeletal System

edited by

Massimiliano Leigheb

Alessandro de Sire

and Cesar de Cesar Netto

submission deadline 31 Dec 2026 | 1 articles | Viewed by 509 | Submission Open

Keywords: musculoskeletal system; diagnostic tools; prognosis; artificial intelligence; augmented reality

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Pulmonary Adenocarcinoma

edited by

Cesar A. Moran

submission deadline 31 Dec 2026 | Viewed by 457 | Submission Open

Keywords: pulmonary adenocarcinoma; diagnosis; molecular testing; imaging analysis; detection

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Deep Learning and Large Models in Ophthalmic Innovations

edited by

Yanwu Xu

Weihua Yang

and Huihui Fang

submission deadline 31 Dec 2026 | Viewed by 429 | Submission Open

Keywords: Artificial Intelligence in ophthalmology; multimodal learning; foundation models; ophthalmic imaging; eye disease diagnosis and treatment

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Endoscopic Ultrasound: Diagnostic and Therapeutic Innovations

edited by

Andrada Seicean

submission deadline 31 Dec 2026 | Viewed by 424 | Submission Open

Keywords: endoscopic ultrasound (EUS); diagnostic and therapeutic innovations; minimally invasive interventions; EUS-guided tissue acquisition; advanced imaging techniques; multidisciplinary gastroenterology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pathogenesis, Diagnosis, and Management of Rheumatic Disease: Progress and Challenges

edited by Miguel Ángel González-Gay

submission deadline 31 Dec 2026 | Viewed by 409 | Submission Open

Keywords: rheumatic disease; systemic vasculitis; rheumatoid arthritis; metabolic syndrome; atherosclerosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Diagnostic and Prognostic Tools in Gynecological Cancer

edited by

Ahmad Sayasneh

submission deadline 31 Dec 2026 | Viewed by 392 | Submission Open

Keywords: gynaecological cancer; diagnostic imaging; artificial intelligence; molecular biomarkers; prognostic models; surgical navigation; precision oncology; translational research

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnosis and Management of Hepatitis

edited by

Qi Wang

submission deadline 31 Dec 2026 | Viewed by 369 | Submission Open

Keywords: viral hepatitis; hepatitis B virus hepatitis; drug-induced liver injury; autoimmune hepatitis; metabolic-associated fatty liver disease; alcoholic liver disease; diagnosis; follow-up management

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Gastrointestinal Endoscopy: Diagnostic Applications and Safety Evaluation

edited by

Giacomo Emanuele Maria Rizzo

Lucía Guilabert

and Sara Nikolic

submission deadline 31 Dec 2026 | Viewed by 368 | Submission Open

Keywords: endoscopy; endoscopic ultrasound; luminal endoscopy; procedural safety; risk assessment; adverse events; sedation protocols

(This special issue belongs to the Section Medical Imaging and Theranostics)

Selected Papers From the 1st International Online Conference on Diagnostics [IOCDi 2026]

edited by

Giorgio Treglia

submission deadline 31 Dec 2026 | Viewed by 339 | Submission Open

Keywords: imaging diagnosis; pathology diagnosis; molecular diagnosis; clinical diagnosis; laboratory medicine; point-of-care diagnosis; artificial intelligence

Computed Tomography Imaging in Medical Diagnosis, Third Edition

edited by

Fabio Sandomenico

submission deadline 31 Dec 2026 | 1 articles | Viewed by 337 | Submission Open

Keywords: computed tomography; medical diagnosis; imaging; internal organs; bones; soft tissue; blood vessels

(This special issue belongs to the Section Medical Imaging and Theranostics)

Data Science and Artificial Intelligence in Laboratory Medicine

edited by

Fernando Marques-Garcia

submission deadline 31 Dec 2026 | Viewed by 303 | Submission Open

Keywords: artificial intelligence; data science; algorithm; laboratory medicine

(This special issue belongs to the Section Clinical Laboratory Medicine)

Liquid Biopsy and Molecular Diagnostics in Neuro-Oncology

edited by Santiago Cabezas-Camarero and Juan Manuel Sepúlveda-Sánchez

submission deadline 31 Dec 2026 | Viewed by 294 | Submission Open

Keywords: liquid biopsy; biofluids; biomarkers; molecular techniques; gliomas; neuro-oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Endoscopic Diagnosis and Management of Tumors

edited by

Longjun He

submission deadline 31 Dec 2026 | Viewed by 284 | Submission Open

Keywords: endoscopy; tumor diagnosis; endoscopic therapy; endoscopic ultrasound; artificial intelligence; early cancer detection; minimally invasive surgery; precision oncology; molecular imaging; translational research

(This special issue belongs to the Section Biomedical Optics)

Innovative Approaches to Vascular Diseases Diagnosis and Management

edited by

Paolo Perini

and

Chiara Martini

submission deadline 31 Dec 2026 | Viewed by 278 | Submission Open

Keywords: vascular imaging; vascular surgery; aortic aneurysm; peripheral arterial disease; venous disease; image-guided therapy; artificial intelligence; 3D printing; medical devices; vascular complications

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precision Diagnostics in Renal Transplantation and Transplant Complications

edited by

Cheng Yang

submission deadline 31 Dec 2026 | Viewed by 254 | Submission Open

Keywords: renal transplantation; precision diagnostics; allograft rejection; non-invasive monitoring; biomarkers; multi-omics; kidney transplant complications; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnostics and Management in the ICU

edited by

Silvia De Rosa

and Sergio Lassola

submission deadline 31 Dec 2026 | Viewed by 235 | Submission Open

Keywords: intensive care unit; hemodynamic monitoring; acute kidney injury; sepsis and septic shock; clinical diagnostics; predictive biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Precision Diagnosis in Musculoskeletal Disorders: Current and Future Directions

edited by

Yuichi Yoshii

submission deadline 31 Dec 2026 | Viewed by 223 | Submission Open

Keywords: precision diagnosis; musculoskeletal imaging; artificial intelligence; quantitative imaging biomarkers; automated morphological analysis; predictive modeling; 3D patient-specific modeling; digital twin; image-guided diagnosis; personalized musculoskeletal care

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis, Prognosis, and Management of Urinary Disease—2nd Edition

edited by

Nicola Longo

and

Massimiliano Creta

submission deadline 31 Dec 2026 | Viewed by 210 | Submission Open

Keywords: urinary disease; diagnosis; prognosis; kidney disease; prostate disease; malignant diseases like kidney cancer, bladder cancer and prostate cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Perspectives in the Diagnosis of Gastroenterological Diseases

edited by Reena Sidhu

submission deadline 31 Dec 2026 | Viewed by 208 | Submission Open

Keywords: small bowel; bleeding; Crohn’s disease; endoscopy; coeliac disease; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Medical Microbiology and Infection: Diagnosis and Management

edited by Hsinyao Wang

submission deadline 31 Dec 2026 | Viewed by 195 | Submission Open

Keywords: medical microbiology; infectious diseases; diagnostic microbiology; infection management; antimicrobial susceptibility testing; non‑antibiotic therapies; clinical microbiology; diagnostic innovation

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Machine Learning in Disease Diagnosis

edited by

Chi-Jie Lu

and

Yi-Wei Kao

submission deadline 31 Dec 2026 | Viewed by 191 | Submission Open

Keywords: machine learning; disease diagnosis; medical/healthcare informatics; multimodal learning; explainable AI (XAI); federated learning; clinical decision support

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Point-of-Care and At-Home Diagnostics for Infectious Diseases

edited by Gregory J. Tobin and Ke Du

submission deadline 31 Dec 2026 | Viewed by 184 | Submission Open

Keywords: infectious agents; at-home diagnostic; point-of-care diagnostic; pathogen surveillance; digital health; novel detection technologies; low-resource settings

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Application of Analytical Techniques in Microbial and Biomarker Research

edited by Hariom Yadav,