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Diagnostics
Special Issues
Advances in the Diagnosis and Management of Autoimmune Rheumatic Diseases
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Advances in the Diagnosis and Management of Autoimmune Rheumatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 966

Special Issue Editor

Prof. Dr. Liangjing Lu

E-Mail Website
Guest Editor
Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interests: rheumatic diseases; systemic sclerosis; systemic lupus erythematosus; rheumatoid arthritis; infections in patients with rheumatic diseases; pregnancies in women with rheumatic diseases

Special Issue Information

Dear Colleagues,

The landscape of autoimmune rheumatic diseases has been revolutionized by significant advances in diagnostic modalities and therapeutic strategies. These developments are crucial not only for achieving early and accurate diagnosis, which is essential to prevent irreversible organ damage, but also for enabling personalized treatment plans, dynamically monitoring disease activity, predicting long-term outcomes, and assessing treatment response. The integration of advanced serological biomarkers and high-resolution imaging techniques such as musculoskeletal ultrasound and MRI, along with novel targeted therapies and treat-to-target approaches, has dramatically improved patient care and prognosis. Furthermore, innovations in multi-omics, artificial intelligence-assisted image interpretation, and the development of validated composite disease activity indices are refining precision in clinical decision making. This Special Issue invites contributions on a broad spectrum of topics, including novel biomarkers, AI-driven diagnostic tools, the application of multi-modal imaging, and the role of targeted biologic and cell and gene therapy in precision rheumatology. We welcome original research, reviews, and clinical studies that contribute to the advancement in the diagnosis, management, and therapeutic assessment of autoimmune rheumatic diseases.

Prof. Dr. Liangjing Lu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmune rheumatic diseases
  • biomarkers
  • precision medicine
  • targeted therapy
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

13 pages, 740 KB  
Article
Pregnancy Loss History Is Associated with Systemic Involvement and Disease Activity in Women with Behçet’s Disease: A Retrospective Cohort Study
by Rui Bu, Yan Ma, Xinyu Li, Qiu Li and Liangjing Lu
Diagnostics 2026, 16(8), 1133; https://doi.org/10.3390/diagnostics16081133 - 10 Apr 2026
Viewed by 522
Abstract
Background/Objectives: Behçet’s disease (BD) is a systemic vasculitis frequently affecting women of childbearing age. However, the relationship between systemic manifestations and pregnancy loss remains unclear. This study evaluated the association between pregnancy loss history and systemic clinical characteristics in women with BD. Methods: [...] Read more.
Background/Objectives: Behçet’s disease (BD) is a systemic vasculitis frequently affecting women of childbearing age. However, the relationship between systemic manifestations and pregnancy loss remains unclear. This study evaluated the association between pregnancy loss history and systemic clinical characteristics in women with BD. Methods: This retrospective cohort study included 114 women with BD followed in a rheumatology outpatient clinic between January 2021 and December 2025. In total, 196 pregnancies were recorded. Women without a pregnancy history were excluded. Pregnancy loss was defined as any spontaneous loss, including biochemical pregnancy, miscarriage, or fetal death, excluding elective terminations. Disease activity was assessed using the Krause score, and univariable logistic regression was performed. Results: Among 97 women with a pregnancy history, 25 (25.8%) had at least one pregnancy loss. Compared with women without pregnancy loss, those with pregnancy loss had longer disease duration and higher Krause scores. Gastrointestinal involvement (OR 6.31, 95% CI 1.87–23.28, p = 0.0035) and ocular involvement (OR 3.93, 95% CI 1.44–10.89, p = 0.0076) were significantly associated with pregnancy loss history. Higher Krause scores were also associated with greater odds of pregnancy loss history. Conclusions: In women with BD, pregnancy loss history was associated with systemic organ involvement and higher disease activity, particularly gastrointestinal and ocular involvement. These findings should be interpreted cautiously in light of the retrospective design and univariable analyses, and they suggest that pregnancy loss history may be associated with greater systemic disease burden. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Autoimmune Rheumatic Diseases)
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