The Role of Real-World Evidence (RWE) in Thoracic Malignancies

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Thoracic Oncology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 550

Special Issue Editors


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Guest Editor
1. Department of Medicine, Division of Medical Oncology, The Ottawa Hospital Cancer Centre, University of Ottawa, Ottawa, ON K1H8L6, Canada
2. Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
Interests: thoracic malignancies; carcinoma unknown primary; real world evidence; medical education; advocacy
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Guest Editor
Verspeeten Family Cancer Center, London Health Sciences Center, London, ON N6A 5W9, Canada
Interests: clinical care; thoracic oncology; head and neck oncology; clinical Trials; evaluating factors that could impact survivorship in the treatment of thoracic and head/neck cancers; medical education; real world evidence generation

Special Issue Information

Dear Colleagues,

Real-world data (RWD) and real-world evidence (RWE) are increasingly important components of a broad research portfolio. RWE has the ability to see clinical care as it really is, complicated and messy, full of idiosyncrasies and oddities that are excluded from the purified world of prospective clinical trials. RWE is now accepted by regulatory bodies such as the FDA, NICE, EMA, and Health Canada, sometimes in a supportive role and sometimes as primary data. In lung cancer, the explosion of rare subtypes is a fertile opportunity for RWE research, but also, with lung cancer being so common, it is possible to generate RWE for large numbers of patients to answer different questions.

In this Special Issue of Current Oncology, we invite submissions of RWE projects with clinical data or papers on the methodology and challenges of RWE. We are interested in the future of RWE, which might involve AI, the increasing capacity of EMRs, or the novel field of synthetic data. By fostering a dialogue around RWE, we aspire to advance the field of thoracic oncology and improve patient care, ultimately leading to better outcomes for those affected by this disease.

We look forward to your submissions.

Dr. Paul Wheatley-Price
Dr. Sara Kuruvilla
Guest Editors

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Keywords

  • real-world evidence (RWE)
  • real word data (RWD)
  • lung cancer
  • thoracic cancers (malignancies)
  • observational studies
  • health economic outcomes research (HEOR)
  • registry(ies)

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Published Papers (1 paper)

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Research

14 pages, 1373 KiB  
Article
Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada
by Ying Wang, Greg Pond, Amiram Jacob Gafni, Chung Yin Kong and Peter M. Ellis
Curr. Oncol. 2025, 32(6), 346; https://doi.org/10.3390/curroncol32060346 - 12 Jun 2025
Viewed by 220
Abstract
Previous studies have noted associations between age and healthcare costs in non-small-cell lung cancer (NSCLC). However, the drivers of cost disparities have not yet been fully examined. This retrospective cohort study included deceased patients diagnosed with stage IV NSCLC in Ontario from 1 [...] Read more.
Previous studies have noted associations between age and healthcare costs in non-small-cell lung cancer (NSCLC). However, the drivers of cost disparities have not yet been fully examined. This retrospective cohort study included deceased patients diagnosed with stage IV NSCLC in Ontario from 1 April 2008 to 30 March 2014. Variables of interest were extracted from the Institute for Clinical Evaluative Sciences. Average monthly cancer-attributable costs (CACs), defined as the net additional costs due to cancer, determined by subtracting pre-diagnosis costs from post-diagnosis costs, were calculated by phases of care (staging, initial, continuing, and end-of-life). Regression analyses assessed predictors of cost variability. The median age of the 14,655 patients was 65 to 69 years; 54% were male and 29% had received chemotherapy. On both univariate and multivariate analysis, CACs decreased with age after cancer diagnosis across all phases of care (p < 0.001). Receiving chemotherapy contributed to higher costs in staging, initial, and continuing phases (OR 2.11, 95% C.I. 1.90–2.33, p < 0.01), and lower costs in the end-of-life phase (OR 0.77, 95% C.I. 0.72–0.81, p < 0.01). Our study showed that older patients had higher baseline healthcare costs and lower cancer-attributable costs following diagnosis of advanced NSCLC. Cost drivers, including treatment and gender, varied by phase of care. Full article
(This article belongs to the Special Issue The Role of Real-World Evidence (RWE) in Thoracic Malignancies)
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