New Advances in the Treatment of Resectable Non-small Cell Lung Cancer

Dear Colleagues,

Despite the evolution in non-small cell lung cancer treatment, the overall prognosis is still poor. In this context, lobectomy and radical lymphadenectomy remain the cornerstone of surgical treatment of resectable NSCLC. One of the most important prognostic factors remains the presence of lymph node involvement, particularly the presence of mediastinal nodal involvement, as demonstrated in the VIII TNM staging system edition with a clear prognosis stratification considering the presence of nodal metastases. Furthermore, correct intraoperative staging is mandatory to reach an actual pathological status of the disease. The recent approval of Osimertinib for resected EGFR-mutated NSCLC in an adjuvant setting has led to the hypothesis that other targeted therapies used in metastatic patients can also lead to improved early-stage outcomes of NSCLC. Indeed, in addition to surgical treatment, some target therapies are being tested in adjuvant settings with promising outcomes. Some trials are open which use these therapies in the neoadjuvant setting. For this Special Issue, we welcome manuscripts focusing on recent advancements in the preoperative staging, the surgical resection of NSCLC, and the role of the new medications approved as adjuvant and neoadjuvant therapies. We also welcome systematic reviews, original research, economic evaluation, and cost-effectiveness studies on this relevant topic.

Dr. Francesco Facciolo
Dr. Luca Bertolaccini
Dr. Federico Cappuzzo
Guest Editors

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