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Current Oncology
Special Issues
Quality of Life and Follow-Up Care Among AYA Cancer Survivors
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Quality of Life and Follow-Up Care Among AYA Cancer Survivors

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Palliative and Supportive Care".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 932

Special Issue Editors

Dr. Neetu Chawla

E-Mail Website
Guest Editor
Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street (Mailcode 152), Sepulveda, CA 91343, USA
Interests: pediatric oncology; adolescent and young adult (AYA) survivors; quality of life; follow-up care; childhood cancer survivors; mixed methods research; qualitative research; patient-provider communication
Dr. Sandra A. Mitchell

E-Mail Website
Guest Editor
Outcomes Research Branch, Healthcare Delivery Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD 20850, USA
Interests: symptom management and supportive care; rehabilitation; patient-reported outcomes; cancer survivorship follow-up care; long-term and late treatment effects; AYA oncology

Special Issue Information

Dear Colleagues,

Adolescent and young adult (AYA) cancer survivors encounter unique challenges that significantly impact their quality of life, necessitating specialized follow-up care. Understanding the evolving needs of these survivors is paramount for delivering comprehensive support to this understudied and growing population. Current research emphasizes the pivotal role of effective patient–provider communication, survivorship care coordination, behavioral and mental health services, peer support, and survivorship care that addresses late and long-term effects.

​​​This Special Issue aims to delve into these critical aspects within the realm of AYA cancer survivorship, striving to enhance the long-term well-being and outcomes of this vulnerable population. Medical professionals and researchers in adolescent and young adult oncology specializing in survivorship care are encouraged to submit their original research as well as review articles to the Special Issue of Current Oncology focusing on how late effects from cancer and its treatments can impact various aspects of quality of life, including cardiovascular, endocrine, brain and spinal cord, and psychosocial health. Research is also encouraged that examines the survivorship care needs of AYA survivors to address these late and long-term effects of cancer treatment, including patterns of healthcare utilization for primary, specialty, oncology, behavioral health, and supportive care services.

Dr. Neetu Chawla
Dr. Sandra A. Mitchell
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adolescent and young adult (AYA) survivors
  • AYA oncology
  • quality of life
  • follow-up care
  • childhood cancer survivors

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Published Papers (2 papers)

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Research

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14 pages, 2479 KiB  
Article
Primary Central Nervous System Tumors in Adolescents: A Population-Based Study on Epidemiology and Clinical Pathways in a Challenging Age Group
by Lucia De Martino, Patrizia Piga, Marcella Sessa, Camilla Calì, Camilla Russo, Stefania Picariello, Nicola Onorini, Pietro Spennato, Lucia Quaglietta, Maria Vittoria Donofrio, Giuseppe Cinalli, Francesco Vetrano and Fabio Savoia
Curr. Oncol. 2025, 32(4), 222; https://doi.org/10.3390/curroncol32040222 - 10 Apr 2025
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Abstract
Background: Oncological care of adolescent patients is often inconsistent, as they frequently fall between pediatric and adult services. The Childhood Cancer Registry of Campania (CCRC) is the Italian largest population-based registry specializing in children 0–19 years old, with a target population of approximately [...] Read more.
Background: Oncological care of adolescent patients is often inconsistent, as they frequently fall between pediatric and adult services. The Childhood Cancer Registry of Campania (CCRC) is the Italian largest population-based registry specializing in children 0–19 years old, with a target population of approximately 1.1 million inhabitants. Material and Methods: This report presents epidemiological indicators and clinical pathways on primary brain tumors in adolescents (15–19 years) from the Campania region. Results: Over the study period (2008–2020), the cohort included 219 adolescents with newly diagnosed central nervous system (CNS) tumors with an annual average incidence rate (IR) of 48.9 cases per million/year. The 5-year observed survival rate after diagnosis of CNS tumor was 84.8%. Overall, the most common tumor site was the pituitary gland and craniopharyngeal duct, representing 22.4% of all tumors. The most frequently occurring malignant primary CNS tumor was germinoma, while the most common non-malignant tumor was pituitary adenoma. Most patients were referred to adult services and nearly half migrated outside the region to receive cancer care. Conclusions: Challenges in the care of adolescent oncology patients include limited access to specialized care, difficulties in transitioning from pediatric to adult institutions, distinct tumor biology, and the underrepresentation of adolescents in clinical trials. The care of adolescents with CNS tumors is fragmented across institutions and significant variations in practice exist between adult and pediatric practitioners. Full article
(This article belongs to the Special Issue Quality of Life and Follow-Up Care Among AYA Cancer Survivors)
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Review

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21 pages, 672 KiB  
Review
Survivorship Considerations and Management in the Adolescent and Young Adult Sarcoma Population: A Review
by Allison Gunderson, Miriam Yun, Babe Westlake, Madeline Hardacre, Nicholas Manguso and Alicia A. Gingrich
Curr. Oncol. 2025, 32(4), 214; https://doi.org/10.3390/curroncol32040214 - 3 Apr 2025
Viewed by 353
Abstract
Soft tissue sarcoma (STS) has an 2–8% incidence for all malignant tumors in the adolescent and young adult (AYA) population, which are patients from ages 15 to 39. As most STS tumors are aggressive, they require multimodal management with surgery, radiation and chemotherapy. [...] Read more.
Soft tissue sarcoma (STS) has an 2–8% incidence for all malignant tumors in the adolescent and young adult (AYA) population, which are patients from ages 15 to 39. As most STS tumors are aggressive, they require multimodal management with surgery, radiation and chemotherapy. This article discusses the survivorship considerations in this young population of cancer patients who complete therapy. The lasting side effects include surgical and radiation-related morbidity, chemotherapy toxicity, early and late secondary effects on other organ systems, such as cardiac and endocrine dysfunction, and the development of secondary cancers. The long-term psychologic and practical impacts for those who have received a sarcoma diagnosis in the prime of their life include fertility, mental health, relationship, education and career implications. Although there is a paucity of data in some of these areas, we present existing management guidelines as available. This article serves as a comprehensive review of this wide array of treatment effects intended for all providers participating in the care of AYA sarcoma survivors, to include oncologists, primary care providers and therapists. Full article
(This article belongs to the Special Issue Quality of Life and Follow-Up Care Among AYA Cancer Survivors)
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