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Current Oncology
Special Issues
Innovation in Gynecologic Cancer Surgery
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Innovation in Gynecologic Cancer Surgery

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gynecologic Oncology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 2617

Editor

Prof. Dr. Sarfraz Ahmad

E-Mail Website
Guest Editor
Clinical Research, Gynecologic Oncology Program, AdventHealth Cancer Institute, Orlando, FL, USA
Interests: clinical and surgical outcomes; gynecologic oncology; robotic surgery in gynecology; hemostasis and thrombosis; hemato-oncology; lifestyle medicine

Special Issue Information

Dear Colleagues,

Hysterectomy remains a cornerstone in the surgical management of gynecologic malignancies, including cervical, endometrial, and ovarian cancers. Over the past decades, advances in surgical techniques, imaging, and oncologic understanding have reshaped the role and extent of hysterectomy in cancer care. Minimally invasive approaches, nerve-sparing techniques, and fertility-preserving options are now being increasingly considered, tailored to the disease stage and patient profile.

This Special Issue aims to explore the current standards and emerging innovations in hysterectomy for gynecologic cancers. We welcome original research, systematic reviews, and expert perspectives that examine surgical approaches, decision-making algorithms, outcomes, complications, and cost-effectiveness. Special attention will be given to evolving topics such as robotic-assisted surgery, individualized surgical planning, quality-of-life outcomes, survivorship, and integration of hysterectomy within multimodal cancer treatment.

By bringing together diverse contributions from surgical oncologists, gynecologists, and innovative researchers, this issue seeks to provide a comprehensive overview of where we stand today and where the field is headed in the surgical treatment of gynecologic cancers.

Prof. Dr. Sarfraz Ahmad
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hysterectomy
  • gynecologic cancers
  • surgical oncology
  • minimally invasive surgery
  • fertility preservation
  • survivorship
  • cost-effectiveness

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

15 pages, 3902 KB  
Article
Neoadjuvant Chemotherapy Followed by Interval Debulking for Advanced-Stage Endometrial Cancer: Survival Outcome Based on Surgical and Molecular Characteristics
by Mira Kheil, Tariq Mekkaoui, Emily Andresan, Gloria Fung, Madison Miller, Jamie G. Joseph, Anqi Wang, Ali Al Asadi, Mohamed Elshaikh, Sarfraz Ahmad and Ahmad Awada
Curr. Oncol. 2026, 33(8), 448; https://doi.org/10.3390/curroncol33080448 - 27 Jul 2026
Viewed by 227
Abstract
Objective: To examine survival outcomes and identify clinicopathological factors associated with survival in patients with advanced-stage endometrial cancer who received neoadjuvant chemotherapy before interval debulking surgery (NACT-IDS). Methods: A single-center retrospective cohort study was conducted of patients who were diagnosed with advanced-stage (2009 [...] Read more.
Objective: To examine survival outcomes and identify clinicopathological factors associated with survival in patients with advanced-stage endometrial cancer who received neoadjuvant chemotherapy before interval debulking surgery (NACT-IDS). Methods: A single-center retrospective cohort study was conducted of patients who were diagnosed with advanced-stage (2009 FIGO IIIB, IIIC, IV) endometrial cancer (2012–2024) and underwent NACT-IDS. Tumor response to NACT was determined with computed tomography and the RECIST criteria, and demographic, clinicopathologic, perioperative, and tumor molecular features (mismatch repair protein [MMR] status and p53 pattern) were collected from medical chart review. Association between tumor molecular features and response to NACT was determined. Primary endpoints were progression-free and overall survival, analyzed with univariate Cox and stratified Kaplan–Meier analysis. Results: Of 42 consecutive patients (median age of 68 years), the majority (n = 26; 61.9%) had a partial tumor response to NACT, with only five (11.9%) having a complete response, four (9.5%) having stable disease, and seven (16.7%) having progressive disease. Most cases had no residual tumor after IDS (n = 35; 83.3%). MMR protein status was associated with the tumor response to NACT (p = 0.013), but p53 status was not. During follow-up, 24 patients died (57.1%), and 31 (73.8%) died or had disease progression. Tumor response to NACT and resection margin status were associated with progression-free survival in unadjusted analyses, but no covariate adjustment was possible with limited sample size. Conclusions: This study highlights MMR-deficiency, response to NACT, and surgical resection status as clinicopathologic features of interest for future studies of prognostic factors and alternative therapies in advanced-stage endometrial cancer. Full article
(This article belongs to the Special Issue Innovation in Gynecologic Cancer Surgery)
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13 pages, 248 KB  
Article
Substantial LVSI Is Independently Associated with Para-Aortic Nodal Metastasis in Patients Undergoing Laparoscopic Surgical Staging for Endometrial Cancer
by Candost Hanedan, Oğuz Kaan Köksal, Şahin Kaan Baydemir, Neslihan Öztürk, Hande Nur Öncü and Vakkas Korkmaz
Curr. Oncol. 2026, 33(7), 430; https://doi.org/10.3390/curroncol33070430 - 18 Jul 2026
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Abstract
Lymphovascular space invasion (LVSI) is a well-established prognostic factor in endometrial cancer; however, its independent contribution to para-aortic nodal metastasis remains incompletely defined. Identifying factors associated with nodal dissemination is important for surgical staging and postoperative management. This retrospective, single-center cohort study included [...] Read more.
Lymphovascular space invasion (LVSI) is a well-established prognostic factor in endometrial cancer; however, its independent contribution to para-aortic nodal metastasis remains incompletely defined. Identifying factors associated with nodal dissemination is important for surgical staging and postoperative management. This retrospective, single-center cohort study included 121 patients with endometrial cancer who underwent laparoscopic pelvic and para-aortic lymphadenectomy. The cohort was predominantly obese (median BMI: 32 kg/m2). Clinicopathological variables were analyzed using univariable and multivariable logistic regression models to identify associations with lymph node metastasis and para-aortic lymph node metastasis. Lymph node metastasis was observed in 16.5% of patients, including para-aortic involvement in 9.9%. In univariable analysis, the LVSI category was significantly associated with lymph node metastasis (p = 0.002), with substantial LVSI being present in 50.0% of patients with nodal metastasis compared with 14.9% of those without. LVSI was categorized as negative, focal, or substantial. In multivariable logistic regression analyses using negative LVSI as the reference category, substantial LVSI remained independently associated with both overall nodal metastasis (OR 5.44, 95% CI 1.67–17.65, p = 0.005) and para-aortic nodal metastasis (OR 6.98, 95% CI 1.81–26.78, p = 0.005), whereas focal LVSI was not significantly associated with either outcome. These findings suggest that the extent of LVSI may be relevant to nodal metastasis, with substantial LVSI showing a stronger association than focal LVSI. Full article
(This article belongs to the Special Issue Innovation in Gynecologic Cancer Surgery)
11 pages, 881 KB  
Article
Recurrence Patterns After Complete Cytoreduction for Advanced Ovarian Cancer: Robotic Versus Open Surgery
by Yossi Tzur, Yoav Brezinov, Tomer Bar-Noy, Amber Yasmeen, Melica Nourmoussavi Brodeur, Shannon Salvador, Walter H. Gotlieb and Susie Lau
Curr. Oncol. 2026, 33(2), 71; https://doi.org/10.3390/curroncol33020071 - 26 Jan 2026
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Abstract
Background: Complete cytoreduction remains the primary surgical objective in advanced ovarian cancer and concerns persist that robotic surgery may result in distinct recurrence patterns and worse oncologic outcomes due to technical limitations, such as the use of pneumoperitoneum, the restricted visualization, and the [...] Read more.
Background: Complete cytoreduction remains the primary surgical objective in advanced ovarian cancer and concerns persist that robotic surgery may result in distinct recurrence patterns and worse oncologic outcomes due to technical limitations, such as the use of pneumoperitoneum, the restricted visualization, and the lack of tactile evaluation. Methods: We retrospectively identified 125 consecutive patients with advanced epithelial ovarian cancer who attained the best outcome surgery can achieve, and compared the outcome of these patients based on whether complete cytoreduction was achieved by laparotomy or robotic surgery. The primary objective was to compare recurrence patterns and secondary analyses assessed perioperative, postoperative, and survival outcomes. Results: Among 125 patients who had complete cytoreduction (78 robotic; 47 open), baseline characteristics were largely comparable, except for higher rates of interval cytoreduction (84.6% vs. 61.7%, p < 0.01) and more PARP inhibitor use (19.2% vs. 6.4%, p = 0.048) in the robotic group. Recurrence patterns did not differ. Operative and postoperative outcomes were likewise comparable. Median disease-free and overall survival were longer in the robotic group. Conclusions: Among patients achieving complete cytoreduction, recurrence patterns and oncologic outcomes were comparable between robotic and open surgery, suggesting that the route of attaining complete cytoreduction did not influence the outcome. Full article
(This article belongs to the Special Issue Innovation in Gynecologic Cancer Surgery)
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