BCMA-Directed CAR-T Therapy in Relapsed or Refractory Multiple Myeloma

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 194

Special Issue Editor


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Guest Editor
Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Westwood, KS 66205, USA
Interests: multiple myeloma; immuno-cellular therapies in multiple myeloma; drug-resistant multiple myeloma; drug-development in heavily treated relapse myeloma

Special Issue Information

Dear Colleagues,

Relapsed or refractory multiple myeloma poses a significant challenge in hematology. BCMA-directed CAR-T therapy has emerged as a promising treatment approach in such cases. This specialized immunotherapy targets the B-cell maturation antigen (BCMA) expressed on myeloma cells, providing a targeted and potentially curative option. However, challenges such as cytokine release syndrome and neurotoxicity persist, requiring careful patient monitoring and management. This Special Issue will explore the latest advancements, outcomes, and challenges in BCMA-directed CAR-T therapy for multiple myeloma, facilitating a deeper understanding of its potential in transforming the landscape of myeloma treatment.

We welcome original research articles and reviews focusing on mechanisms, clinical outcomes, and future directions in BCMA-directed CAR-T therapy.

I look forward to receiving your contributions.

Dr. Al-Ola A. Abdallah
Guest Editor

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Keywords

  • BCMA-directed CAR-T therapy
  • multiple myeloma
  • relapsed multiple myeloma
  • refractory multiple myeloma
  • B-cell maturation antigen
  • immunotherapy
  • treatment outcomes

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Published Papers (1 paper)

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Review

14 pages, 561 KiB  
Review
BCMA CAR-T: From Multiple Myeloma to Light-Chain Amyloidosis
by Ellen Lewis and Victor Hugo Jimenez-Zepeda
Curr. Oncol. 2025, 32(8), 418; https://doi.org/10.3390/curroncol32080418 - 25 Jul 2025
Abstract
Light-chain (AL) amyloidosis is a rare clonal plasma cell disorder that, if left untreated, carries a high risk of organ damage and mortality. Due to the rarity of the disease and the vulnerability of affected organ systems, treatment requires significant caution and nuance. [...] Read more.
Light-chain (AL) amyloidosis is a rare clonal plasma cell disorder that, if left untreated, carries a high risk of organ damage and mortality. Due to the rarity of the disease and the vulnerability of affected organ systems, treatment requires significant caution and nuance. As a plasma cell dyscrasia, AL amyloidosis treatment regimens are often adapted from those used for related disorders, particularly multiple myeloma. Despite substantial progress in research and drug development, optimal treatment strategies for relapsed/refractory (RR) AL amyloidosis remain unclear, and no FDA-approved therapies currently exist for this setting. B-cell maturation antigen (BCMA) has emerged as a promising immunotherapy target, with associated drug classes including antibody–drug conjugates, bispecific antibodies, and CAR-T cell therapies. These therapies have been extensively studied in relapsed/refractory multiple myeloma (RRMM) and are now being explored in the context of RR AL amyloidosis. This review summarizes the current literature on the efficacy and tolerability of BCMA-directed therapies in AL amyloidosis, with a particular emphasis on CAR-T cell therapy and offers comparisons to outcomes observed in RRMM. Full article
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