Cardiovascular Effects of COVID-19: Acute and Chronic

A special issue of COVID (ISSN 2673-8112). This special issue belongs to the section "COVID Clinical Manifestations and Management".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 425

Special Issue Editor


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Guest Editor
The Carl & Edyth Lindner Center for Research & Education, Cincinnati, OH, USA
Interests: coronary disease; COVID; STEMI; microvascular dysfunction; refractory angina

Special Issue Information

Dear Colleagues,

COVID had a significant impact on patients with cardiovascular disease as well as the entire cardiovascular community.  The direct effects of COVID on acute coronary syndromes including STEMI and thrombotic complications including DVT’s, pulmonary embolism as well as microvascular thrombi that occurred in multiple vascular distributions have been well documented. The cardiovascular community was also impacted by the indirect effects which included the public health measures implemented which resulted in hospital avoidance, decreases in compliance with cardiovascular medications and reduction in cardiovascular testing and procedures that was quite dramatic. While many of these direct and indirect effects of COVID have improved, we continue to see the impact in patients with long COVID, a complex syndrome with components of both inflammation and microvascular dysfunction. In this special issue we will highlight  both the acute and the chronic effects of COVID on cardiovascular disease.

Dr. Timothy D. Henry
Guest Editor

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Keywords

  • microthrombi
  • STEMI
  • long COVID
  • COVID related acute coronary syndromes
  • cardiovascular effects of COVID
  • biology
  • immune response
  • genetics
  • endothelial health

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Published Papers (1 paper)

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Research

19 pages, 544 KiB  
Article
Treatment Times and In-Hospital Mortality Among Patients with ST-Elevation Myocardial Infarction Throughout the Waves of the COVID-19 Pandemic: Lessons Learned
by Jessica K. Zègre-Hemsey, Abhinav Goyal, Remy Poudel, Kathie Thomas, Murtuza J. Ali, Patricia Best, Mark Bieniarz, Gregg C. Fonarow, William French, Christopher B. Granger, Timothy D. Henry, Haoyun Hong, James Jollis, Michael Redlener, Travis Spier, Harper Stone, Feras Wahab, Lanjing Wang and Alice K. Jacobs
COVID 2025, 5(8), 114; https://doi.org/10.3390/covid5080114 - 25 Jul 2025
Viewed by 324
Abstract
Previous studies about the COVID-19 pandemic on STEMI patient outcomes have conflicting results. It remains unclear if this may be attributed to regional differences and/or differences during COVID-19 wave periods. Using the American Heart Association Get With The Guidelines–Coronary Artery Disease registry data, [...] Read more.
Previous studies about the COVID-19 pandemic on STEMI patient outcomes have conflicting results. It remains unclear if this may be attributed to regional differences and/or differences during COVID-19 wave periods. Using the American Heart Association Get With The Guidelines–Coronary Artery Disease registry data, we evaluated (1) time metrics related to STEMI system goals and (2) regional variation in STEMI incidence and in-hospital mortality during pandemic wave time periods. The study included all patients 18–100 years old admitted with STEMI (n = 72,516) to 1 of 435 American Heart Association Get With The Guidelines–Coronary Artery Disease hospitals (1 October 2019–31 December 2021). Of these, 70.8% were male and 73.0% non-Hispanic White, with a median age of 63 (IQR 18) years. Compared to pre-pandemic time frames, patients with STEMI had a higher risk profile, delayed time to treatment, were treated with fibrinolytic therapy or primary PCI, and were transferred for primary PCI at similar rates, and had higher adjusted in-hospital mortality (during the second wave in the South and Midwest). Preservation of STEMI systems of care resulted in an overall lower in-hospital mortality rate than predicted, although opportunities exist to improve treatment delays. Regional differences in mortality rates require further study. Full article
(This article belongs to the Special Issue Cardiovascular Effects of COVID-19: Acute and Chronic)
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