Special Issue "Vascular Signalling"
Deadline for manuscript submissions: closed (31 October 2020).
Interests: endothelial cells; blood–neural barrier; vascular permeability; cell signalling; protein phosphorylation
Interests: vascular endothelial growth factor; calcium signalling; vascular leakage; retina
In all vertebrates, the closed blood and open lymph circulatory systems are essential for the delivery of nutrients and oxygen to tissues, waste clearance, and immune function. Endothelial cells line the vessel walls and regulate the passage of molecules and cells to and from the underlying tissue. Mural cells, such as vascular smooth muscle cells and pericytes, define the nature of the vasculature, which displays vast differences: physically, such as seen between arteries and veins, as well as functionally and morphologically, as illustrated by filtrating microvessels in the kidney and the highly impermeable blood–brain barrier.
The vasculature is highly dynamic, with complex cellular programmes regulating new blood vessel formation through vasculogenesis or angiogenesis, lumen formation, and endothelial cell migration in mature vessels. Recent data also demonstrate the intimate integration of dynamic vascular functions and metabolic demands and availability.
Importantly, with regard to human disease, vascular abnormalities underly or accompany the majority of cardiovascular diseases, such as arteriosclerosis, but also a wide variety of a priori non-vascular diseases, such as cancer, inflammation, neurodegeneration, or metabolic diseases.
Central to the homeostatic and pathological mechanisms of the vasculature are highly specific intracellular and intercellular signalling, as well as genetic programmes, which are exquisitely responsive to growth factors, cytokines, nucleic acids, and lipids.
The aim of this Special Issue is to assemble original data and reviews illustrating the plethora of cellular signalling that typifies vascular behavior and responsiveness during health and disease. We hope that contributions from expert laboratories will result in a compendium supporting researchers with a vested interest in vascular function, and those aiming to be intitiated into this fascinating area of vertebrate biology.
Prof. Patric Turowski
Dr. Silvia Dragoni
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell signalling
- cardiovascular diseases
- vascular smooth muscle cells