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It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology

Knaus-Lab/Signal Transduction, Institute for Chemistry and Biochemistry, Freie Universitaet Berlin, 14195 Berlin, Germany
Author to whom correspondence should be addressed.
Cells 2020, 9(9), 1965;
Received: 22 July 2020 / Revised: 19 August 2020 / Accepted: 22 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Vascular Signalling)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGFβ) superfamily of cytokines. While some ligand members are potent inducers of angiogenesis, others promote vascular homeostasis. However, the precise understanding of the molecular mechanisms underlying these functions is still a growing research field. In bone, the tissue in which BMPs were first discovered, crosstalk of TGFβ/BMP signaling with mechanobiology is well understood. Likewise, the endothelium represents a tissue that is constantly exposed to multiple mechanical triggers, such as wall shear stress, elicited by blood flow or strain, and tension from the surrounding cells and to the extracellular matrix. To integrate mechanical stimuli, the cytoskeleton plays a pivotal role in the transduction of these forces in endothelial cells. Importantly, mechanical forces integrate on several levels of the TGFβ/BMP pathway, such as receptors and SMADs, but also global cell-architecture and nuclear chromatin re-organization. Here, we summarize the current literature on crosstalk mechanisms between biochemical cues elicited by TGFβ/BMP growth factors and mechanical cues, as shear stress or matrix stiffness that collectively orchestrate endothelial function. We focus on the different subcellular compartments in which the forces are sensed and integrated into the TGFβ/BMP growth factor signaling.
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Keywords: BMP; TGFβ; mechanobiology; endothelial-cell; shear stress BMP; TGFβ; mechanobiology; endothelial-cell; shear stress
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MDPI and ACS Style

Hiepen, C.; Mendez, P.-L.; Knaus, P. It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology. Cells 2020, 9, 1965.

AMA Style

Hiepen C, Mendez P-L, Knaus P. It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology. Cells. 2020; 9(9):1965.

Chicago/Turabian Style

Hiepen, Christian, Paul-Lennard Mendez, and Petra Knaus. 2020. "It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology" Cells 9, no. 9: 1965.

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