Special Issue "Neuroglobin from Brain Protection to Cancer Progression"
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 31 October 2021.
Special Issue Editors
Special Issues and Collections in MDPI journals
Interests: inherited metabolic disorders; metabolomics; newborn screening; proteomics; protein-protein interaction
Special Issues and Collections in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroglobin (Ngb) is a globin that is physiologically expressed in a widespread manner and in modest quantities in the brain areas and in the peripheral nervous system. Its cerebral distribution and its active role as an oxidative stress sensor and cytoprotective factor against redox imbalance lead us to consider that Ngb is part of endogenous neuroprotective pathways and elucidating a new scenario in the possibility of discovering new therapeutic approaches. In fact, the increase in Ngb levels protects neurons from oxidative stress, glutamate toxicity and apoptosis, with a clear protective effect against neurodegeneration.
However, Ngb has recently been recognized as a new tumor-associated protein, highlighting the role of this globin in regulating both the stress-induced apoptotic pathway and the antioxidant systems activated by cancer cells. Although the exact role of Ngb as a cancer promoter or tumor suppressor is still debated, some evidence of increased Ngb expression in nervous system tumors, related to the degree of malignancy, suggests a critical role for Ngb in neoplastic growth.
In recent years, efforts have been made to investigate the molecular mechanisms underlying the neuroprotective effects of Ngb, which, however, when they occur in tumors, may confer to Ngb a critical role in tumor progression.
Dr. Roberta Misasi
Prof. Maria Marino
Prof. Margherita Ruoppolo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress and antioxidant systems
- reactive oxygen species (ROS)
- mitochondrial dysfunction
- neuroprotection and neurodegenerative diseases
- apoptosis
- autophagy
- tumor progression in the nervous system
- proteic signature
- onteratomics
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Title: Neuroglobin in retinal neurodegeneration: a potential target in therapeutic approaches
Authors: Virginia Solar Fernandez; Mattia di Paolo; Stefano Di Marco; Marco Fiocchetti
Affiliation: Department of Science, University Roma Tre, 00146 Rome, Italy
2. Title: Neuroglobin: a Globin in the Nervous System
Authors: Paolo Ascenzi; Giovanna De Simone; Maria Marino
Affiliation: Department of Sciences, Roma Tre University, Viale Marconi 446, I-00146 Roma, Italy
3. Title: To be determined
Authors: Elisabetta Orlandini; et al.
Affiliation: Research Center “E. Piaggio”, University of Pisa, 56122 Pisa, Italy
4. Title: To be determined
Authors: Francesca Persichetti; et al.
Affiliation: Department of Health Sciences, Università del Piemonte Orientale and IRCAD, Novara, Italy
5. Title: To be determined
Authors: Roberta Misasi; et al.
Affiliation: Department of Experimental Medicine, University of Rome “La Sapienza”, 00161 Rome, Italy