Proteomics and Metabolomics in Human Health and Disease

Dear Colleagues,

Over the past two decades, the omics revolution has significantly advanced our understanding of human health and disease. Each omics discipline has developed into a specialized field, offering powerful insights into the complex molecular networks that underlie biological functions and dysfunctions.  

Proteomics and metabolomics show the ability to capture the dynamic biochemical landscape. Proteomics involves the large-scale study of protein expression and modifications to disclose pathological processes, while metabolomics focuses on small molecules and lipids, providing a real-time snapshot of metabolic activities and cellular phenotypes. Together, these approaches deliver a detailed molecular fingerprint that can reveal subtle, yet clinically significant, changes associated with disease onset, progression, or treatment response. Moreover, the integration of multiple omics data types has emerged as a transformative approach in biomedical research, enabling a more comprehensive exploration of disease mechanisms and the discovery of novel diagnostic and therapeutic targets.

This Special Issue invites contributions that apply proteomics and metabolomics to biomedical research, particularly those addressing disease-related questions through experimental innovation or computational integration. This collection will contribute to a more precise, system-level understanding of health and disease, with wide-ranging applications in both basic science and personalized medicine.

Dr. Michele Costanzo
Prof. Dr. Margherita Ruoppolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.