Special Issue "Microenvironment Signals in Malignant B Cells"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editors

Dr. Maria Teresa Scupoli
E-Mail Website
Guest Editor
Department of Neurosciences, Biomedicine and Movement Sciences, Università degli Studi di Verona, 37134 Verona, Italy
Interests: cancer; lymphoid leukemia; signal transduction; leukemic microenvironment
Dr. Francesco Piazza
E-Mail Website1 Website2
Co-Guest Editor
Department of Medicine, Hematology Via Giustiniani 2, 35128 Padova, Italy
Interests: B-cell malignancies: multiple myeloma, B-lymphoid leukemia and lymphoma; signal transduction; tumor microenvironment; novel targeted therapies

Special Issue Information

Dear Colleagues,

B-cell malignancies are a heterogeneous group of hematological neoplasms derived from cells at different stages of B-cell development. Malignant B cells develop in specialized tissue microenvironments, such as bone marrow and secondary lymphoid organs, where they receive supportive signals promoting tumor proliferation and survival. The tumor microenvironments of B-cell malignancies are highly variable in terms of spatial organization and composition of accessory cells, which include immune and inflammatory cells, in addition to blood and lymphatic vascular meshwork. The cellular components of the microenvironment generally reflect those of the normal counterpart and interact with malignant B cells through a complex network of soluble factors, chemokine receptors, and adhesion molecules. Furthermore, antigenic stimulation mediated by the B-cell receptor (BCR) plays a prominent pathogenetic role in mature B-cell malignancies. The degree of interactions and dependance of malignant cells on the microenvironments for survival and proliferation deeply differ across types of B-cell malignancies, extending from a high dependence on the microenvironment for growth to an autonomous, microenvironment-independent growth. Several lines of evidence support the crucial role of microenvironment signals in controlling the pathogenesis, development, and drug resistance of B-cell malignancies. On the other hand, malignant cells can shape the microenvironment to promote immunosuppressive and escaping mechanisms aimed at avoiding immune surveillance. Increasing evidence also indicates that the tumor microenvironment can induce treatment resistance.

The elucidation of mechanisms involved in the crosstalk between tumor cells and microenvironment is of preeminent importance to understand the biological mechanisms of diseases and develop novel treatments of patients with hematologic malignancies. 

This Special Issue intends to provide an Open Access forum collecting original research and review articles addressing cellular and molecular pathways involved in the crosstalk between malignant B cells and their microenvironments.

Dr. Maria Teresa Scupoli
Guest Editor

Dr. Francesco Piazza
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Bone marrow stroma
  • immune evasion
  • lymphoma microenvironment
  • leukemia microenvironment

Published Papers

This special issue is now open for submission.
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