The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
National Institute of Gastroenterology “S. De Bellis”, Research Hospital, Castellana Grotte, 70013 Bari, Italy
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Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2019, 8(10), 1130; https://doi.org/10.3390/cells8101130
Received: 10 July 2019
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Revised: 16 September 2019
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Accepted: 17 September 2019
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Published: 23 September 2019
(This article belongs to the Special Issue TGF-beta/BMP Signaling Pathway)
The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, but also for adult tissue homeostasis. The proper functioning of the TGFβ/BMP pathway depends on its communication with other signaling pathways and any deregulation leads to developmental defects or diseases, including fibrosis and cancer. In this review we explore the cellular and physio-pathological contexts in which the synergism or antagonism between the TGFβ and BMP pathways are crucial determinants for the normal developmental processes, as well as the progression of fibrosis and malignancies.
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Keywords:
TGFβ; signaling; BMPs; SMAD pathway; Non-SMAD signaling; development; adult homeostasis; disease; fibrosis; cancer
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MDPI and ACS Style
Dituri, F.; Cossu, C.; Mancarella, S.; Giannelli, G. The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer. Cells 2019, 8, 1130. https://doi.org/10.3390/cells8101130
AMA Style
Dituri F, Cossu C, Mancarella S, Giannelli G. The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer. Cells. 2019; 8(10):1130. https://doi.org/10.3390/cells8101130
Chicago/Turabian StyleDituri, Francesco, Carla Cossu, Serena Mancarella, and Gianluigi Giannelli. 2019. "The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer" Cells 8, no. 10: 1130. https://doi.org/10.3390/cells8101130
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