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Article

Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4

Department of Cell Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(7), 722; https://doi.org/10.3390/cells8070722
Received: 24 May 2019 / Revised: 6 July 2019 / Accepted: 13 July 2019 / Published: 14 July 2019
(This article belongs to the Special Issue TGF-beta/BMP Signaling Pathway)
Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progression. In the present study, we analyse whether acute lymphoblastic leukaemia (ALL) cells can affect the differentiation of dendritic cells and macrophages and the involvement of BMP pathway in the process. We show that ALL cells produce BMP4 and that conditioned media from ALL cells promote the generation of dendritic cells with immunosuppressive features and skew M1-like macrophage polarization towards a less pro-inflammatory phenotype. Likewise, BMP4 overexpression in ALL cells potentiates their ability to induce immunosuppressive dendritic cells and favours the generation of M2-like macrophages with pro-tumoral features. These results suggest that BMP4 is in part responsible for the alterations in dendritic cell and macrophage differentiation produced by ALL cells. View Full-Text
Keywords: acute lymphoblastic leukaemia; BMP4; dendritic cells; macrophages; tumour immune microenvironment acute lymphoblastic leukaemia; BMP4; dendritic cells; macrophages; tumour immune microenvironment
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MDPI and ACS Style

Valencia, J.; M. Fernández-Sevilla, L.; Fraile-Ramos, A.; Sacedón, R.; Jiménez, E.; Vicente, A.; Varas, A. Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4. Cells 2019, 8, 722. https://doi.org/10.3390/cells8070722

AMA Style

Valencia J, M. Fernández-Sevilla L, Fraile-Ramos A, Sacedón R, Jiménez E, Vicente A, Varas A. Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4. Cells. 2019; 8(7):722. https://doi.org/10.3390/cells8070722

Chicago/Turabian Style

Valencia, Jaris, Lidia M. Fernández-Sevilla, Alberto Fraile-Ramos, Rosa Sacedón, Eva Jiménez, Angeles Vicente, and Alberto Varas. 2019. "Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4" Cells 8, no. 7: 722. https://doi.org/10.3390/cells8070722

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