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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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PD-(L)1-Centered Immune Combination Therapy: Synergistic Mechanisms and Clinical Breakthroughs
edited by
submission deadline 31 Mar 2027 | Viewed by 69 | Submission Open
Keywords: PD-1/PD-L1 blockade; combination immunotherapy; tumor microenvironment; immune resistance; cold-to-hot tumor conversion
Improving Lung Cancer Outcomes Through Innovation in Screening and Early Detection
edited by Dan J. Raz
submission deadline 31 Mar 2027 | Viewed by 69 | Submission Open
Keywords: lung cancer screening; early lung cancer detection; low-dose CT; artificial intelligence; liquid biopsy; biomarkers; radiomics; risk stratification; health equity; implementation science
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Large Language Models and Agentic AI in the Management of Thoracic and Abdominal Malignancies: From Diagnosis to Survivorship
edited by
submission deadline 31 Mar 2027 | Viewed by 66 | Submission Open
Keywords: large language models; agentic AI; thoracic malignancies; abdominal malignancies; clinical decision support; electronic health records; patient education and survivorship; clinical trial matching; AI safety and evaluation; privacy-preserving deployment
Computational Innovations Enabling Precision Oncology
edited by and
submission deadline 31 Mar 2027 | Viewed by 65 | Submission Open
Keywords: bioinformatics; genomics; proteomics; microbiomics; metabolomics; multi-omics; machine learning; deep learning; medical informatics; drug discovery
Cancer Cell Metabolism and Tumor Microenvironment Remodeling
edited by
submission deadline 31 Mar 2027 | Viewed by 53 | Submission Open
Keywords: metabolic reprogramming; tumor microenvironment; immunometabolism; cell death; single-cell and spatial multi-omics; oncolytic virotherapy; therapy resistance
(This special issue belongs to the Section Tumor Microenvironment)
Emerging Concepts in HER2 Breast Cancer: From Resistance Mechanisms to Next-Generation Therapies
edited by Xiaoting Zhang
submission deadline 31 Mar 2027 | Viewed by 53 | Submission Open
Keywords: HER2; breast cancer; treatment resistance; tumor microenvironment; immune evasion; epigenetics; transcriptional regulation; biomarkers; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Precision Molecular Diagnostics and Biomarker-Driven Pathology in Breast and Gynecologic Cancers
edited by
submission deadline 31 Mar 2027 | Viewed by 41 | Submission Open
Keywords: tumor genomics; molecular diagnosis; predictive biomarkers; targeted therapies; antibody–drug conjugates; homologous recombination deficiency; breast cancer; gynecologic cancer
Clinical Treatment of Pediatric Solid Tumors
edited by Sara Claire Horton
submission deadline 31 Mar 2027 | Viewed by 32 | Submission Open
Keywords: pediatric solid tumor; pediatric radiation therapy; pediatric oncology; pediatric sarcoma; pediatric liver tumor; pediatric renal tumor; pediatric surgical oncology
(This special issue belongs to the Section Pediatric Oncology)
Cellular Plasticity in Cancer
edited by Farzana Alam
submission deadline 31 Mar 2027 | Viewed by 26 | Submission Open
Keywords: cellular plasticity; tumor heterogeneity; epithelial–mesenchymal transition; cancer stem cells; cell fate reprogramming; tumor microenvironment; therapy resistance; metastasis; single-cell omics; cancer evolution
(This special issue belongs to the Section Molecular Cancer Biology)
From Bench to Bedside: The Evolving Role of Gene and Cell Therapy in Oncology
edited by Jacquelyn J. Bower
submission deadline 31 Mar 2027 | Viewed by 18 | Submission Open
Keywords: cancer gene therapy; cell therapy; adeno-associated virus; lentivirus; immunotherapy; oncolytic viruses; cancer stem cells; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Screening and Surveillance of Gastrointestinal and Pancreatic Cancers: 2nd Edition
edited by and Darina Kohoutová
submission deadline 31 Mar 2027 | Viewed by 1 | Submission Open
Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Targeting JAK/STAT Signaling Pathways for Studying Cancer Pathogenesis, Discovering Cancer Markers, Developing Therapies, and Bypassing Drug Resistance
edited by
submission deadline 1 Apr 2027 | Viewed by 357 | Submission Open
Keywords: JAK-STAT; cancer markers; drug resistance; tumoroids; CAR T-cell therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Neoadjuvant and Perioperative Therapy for Lung Cancer
edited by Erminia Massarelli
submission deadline 1 Apr 2027 | Viewed by 102 | Submission Open
Keywords: neoadjuvant therapy; perioperative therapy; lung cancer; immunotherapy; immune checkpoint inhibitors; targeted therapy; pathological complete response; event-free survival; biomarkers; circulating tumor DNA
(This special issue belongs to the Section Cancer Therapy)
Updates on Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes
edited by
submission deadline 1 Apr 2027 | Viewed by 85 | Submission Open
Keywords: tumor hypoxia; hypoxia-targeted therapy; HIF signaling; therapeutic resistance; tumor microenvironment; cancer metabolism; hypoxia-activated prodrugs; combination therapy; precision oncology
Complications After Gastrectomy for Cancer
edited by , Simone Giacopuzzi and Felix Berlth
submission deadline 1 Apr 2027 | Viewed by 11 | Submission Open
Keywords: gastric cancer; gastrectomy; surgical oncology; postoperative complications; postoperative morbidity; anastomotic leakage; duodenal stump leakage; minimally invasive surgery; robotic surgery; perioperative care; prehabilitation; enhanced recovery after surgery; failure to rescue; nutritional outcomes; quality of life; multicenter registries; clinical decision support; postoperative bleeding; cardiopulmonary complications; delayed gastric emptying; postoperative nutritional impairment
Advances in Immunotherapy and Targeted Therapy for Lung Cancer
edited by
submission deadline 3 Apr 2027 | 1 articles | Viewed by 1111 | Submission Open
Keywords: thoracic oncology; immune checkpoint inhibitor; antibody-drug conjugate; bispecific antibody; targeted therapy; precision medicine; combination therapy; biomarker
(This special issue belongs to the Section Cancer Therapy)
Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition
edited by
submission deadline 9 Apr 2027 | 4 articles | Viewed by 16853 | Submission Open
Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives submission deadline 10 Apr 2027 | 2 articles | Viewed by 2041 | Submission Open
Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship
(This special issue belongs to the Section Clinical Research in Cancer)
Robotic Versus Laparoscopic Surgery for Colorectal Cancer
edited by Richard Garfinkle and Nicholas P. McKenna
submission deadline 10 Apr 2027 | 1 articles | Viewed by 820 | Submission Open
Keywords: colon cancer; rectal cancer; colorectal cancer; robotic surgery; laparoscopic surgery; transanal surgery; minimally invasive surgery
(This special issue belongs to the Section Methods and Technologies Development)
Flow Cytometry and Molecular Studies in Hematological Malignancies
edited by Kirill A. Lyapichev
submission deadline 10 Apr 2027 | Viewed by 585 | Submission Open
Keywords: flow cytometry; molecular studies; hematological neoplasms; lymphoma; leukemia
(This special issue belongs to the Section Molecular Cancer Biology)
Rare Genitourinary Cancers submission deadline 15 Apr 2027 | 2 articles | Viewed by 2572 | Submission Open
Keywords: rare genitourinary tumors; penile cancer; testicular cancer; urethral cancer; adrenal cancer; variant histology; upper tract urothelial carcinoma; extramammary Paget’s disease; urologic oncology; rare cancers
(This special issue belongs to the Section Clinical Research in Cancer)
Pain Management and Palliative Care for Patients with Advanced Cancer
edited by Magdalena Anitescu
submission deadline 15 Apr 2027 | Viewed by 158 | Submission Open
Keywords: interventional pain procedures; cancer-related pain; radiological images in spine metastases; palliative surgical interventions; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Cellular Pharmacology for Cancer Therapy: Drug Response, Resistance and Precision Treatment Strategies
edited by and Mitesh Patel
submission deadline 15 Apr 2027 | Viewed by 74 | Submission Open
Keywords: cellular pharmacology; cancer therapy; drug response; drug resistance; precision oncology; targeted therapy; combination therapy; tumour microenvironment; pharmacogenomics; anticancer drug development
(This special issue belongs to the Section Cancer Drug Development)
Biomarker-Driven Treatment in Breast Cancer: From Genomic Profiling to Antibody–Drug Conjugates
edited by and Caterina Marchiò
submission deadline 15 Apr 2027 | Viewed by 34 | Submission Open
Keywords: breast cancer; personalized treatment; risk-adapted treatment strategies; molecular diagnostics; plasticity; comprehensive genomic profiling
(This special issue belongs to the Section Cancer Biomarkers)
Precision Medicine and Therapeutic Innovation in Pancreatic Cancer
edited by Ben George
submission deadline 16 Apr 2027 | Viewed by 60 | Submission Open
Keywords: pancreatic cancer; KRAS; targeted therapy; immunotherapy; surgery; clinical trial; genomic profiling; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Advances in Precision Medicine for Chronic Lymphocytic Leukemia
edited by
submission deadline 18 Apr 2027 | Viewed by 59 | Submission Open
Keywords: CLL; precision medicine; patient comorbidities; logistics; patient preference
(This special issue belongs to the Section Cancer Therapy)
Emerging Biomarkers for Immune Checkpoint Inhibitor Sensitivity and Resistance in Non-Small-Cell Lung Cancer
edited by Minglei Zhuo
submission deadline 20 Apr 2027 | Viewed by 571 | Submission Open
Keywords: non-small-cell lung cancer; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers; tumor microenvironment; PD-L1; circulating biomarkers; microbiota; translational oncology; combination strategies
(This special issue belongs to the Section Cancer Biomarkers)
Computational Oncology: Machine Learning, Digital Biomarkers, and Clinical Decision Support submission deadline 20 Apr 2027 | Viewed by 238 | Submission Open
Keywords: computational oncology; machine learning; deep learning; digital biomarkers; clinical decision support; precision oncology; explainable artificial intelligence; radiomics; multi-omics integration; cancer diagnosis and prognosis
(This special issue belongs to the Section Cancer Informatics and Big Data)
Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer
edited by and
submission deadline 25 Apr 2027 | 1 articles | Viewed by 1769 | Submission Open
Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)
(This special issue belongs to the Section Methods and Technologies Development)
Oxidative Stress and Antioxidants: Mechanisms and Therapeutic Advances in Cancer
edited by , Ankur Sharma and
submission deadline 28 Apr 2027 | Viewed by 26 | Submission Open
Keywords: oxidative stress; antioxidants; therapeutic; cancer; apoptosis; anticancer drugs; nano antioxidants
Surgery and Clinical Outcomes in Head and Neck Squamous Cell Carcinoma
edited by and Mihir R. Patel
submission deadline 29 Apr 2027 | Viewed by 69 | Submission Open
Keywords: head and neck tumors; surgery; therapy; biomarkers; salivary tumors; thyroid tumors
(This special issue belongs to the Section Clinical Research in Cancer)
Prevention, Early Detection, and Surgical Oncology in Hepatocellular Carcinoma, Pancreatic Cancer, and Gastrointestinal Cancer
edited by and
submission deadline 30 Apr 2027 | 7 articles | Viewed by 14256 | Submission Open
Keywords: early image detection in cancer; biomarker of cancer; surgical treatment; gastrointestinal cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression
edited by Shilpi Singh
submission deadline 30 Apr 2027 | 3 articles | Viewed by 8005 | Submission Open
Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Tumor Microenvironment Dynamics in Hepatocellular Carcinoma
edited by Joseph Franses and Adam Burgoyne
submission deadline 30 Apr 2027 | 3 articles | Viewed by 6831 | Submission Open
Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions
(This special issue belongs to the Section Tumor Microenvironment)
Personalizing Head and Neck Cancer Care
edited by and
submission deadline 30 Apr 2027 | 3 articles | Viewed by 5448 | Submission Open
Keywords: head and neck cancer; personalized treatment; targeted therapy; prehabilitation; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms submission deadline 30 Apr 2027 | 2 articles | Viewed by 3075 | Submission Open
Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Advanced Strategies for Precision Therapy in Urinary Cancers
edited by Menghuan Tang and
submission deadline 30 Apr 2027 | 3 articles | Viewed by 2472 | Submission Open
Keywords: urological oncology; precision drug delivery system; nanomaterials; stimuli-responsive delivery; immunotherapy; radioligand therapy
(This special issue belongs to the Section Cancer Therapy)
Socio-Demographic Factors and Cancer Research: 2nd Edition
edited by and Amanda N. Goldin
submission deadline 30 Apr 2027 | 3 articles | Viewed by 2025 | Submission Open
Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Clinical Treatment and Outcomes of Gastrointestinal Cancer
edited by Mary Linton Peters
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1952 | Submission Open
Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation
(This special issue belongs to the Section Clinical Research in Cancer)
Current Applications and Cutting-Edge Innovations in Neuroendoscopy for Oncological Neurosurgery: Where Are We and Where Are We Going?
edited by Giuseppe Roberto Giammalva, Giovanni Tringali and
submission deadline 30 Apr 2027 | 1 articles | Viewed by 1950 | Submission Open
Keywords: neuroendoscopy; endoventricular surgery; skull base surgery; endoscopic assisted neurosurgery; innovations
(This special issue belongs to the Section Methods and Technologies Development)
Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment
edited by Shahidul M. Islam
submission deadline 30 Apr 2027 | 1 articles | Viewed by 1771 | Submission Open
Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling
(This special issue belongs to the Section Tumor Microenvironment)
Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1633 | Submission Open
Keywords: breast cancer; combination therapy; endocrine therapy; chemoradiation; monoclonal antibodies; antibody–drug conjugates (ADCs); small-molecule kinase inhibitors; immunotherapy; predictive biomarkers; therapy resistance; precision oncology; translational research
(This special issue belongs to the Section Cancer Therapy)
Mesothelioma Today: Global Trends, Clinical Challenges, and Policy Responses
edited by and Marco Tomasetti
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1310 | Submission Open
Keywords: malignant mesothelioma; asbestos exposure; occupational cancer; epidemiology; public health policy
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Tumour–Immune Interactions in Cancer Therapy submission deadline 30 Apr 2027 | Viewed by 1125 | Submission Open
Keywords: tumour‑immune interactions; tumour immune microenvironment; immune escape; treatment response; therapy resistance; tumour heterogeneity; immunotherapy; chemotherapy; radiotherapy; targeted therapy; functional genomics; organoids; antigen presentation; translational research; clinical trials; single‑cell & spatial analysis
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Research in Gynecological Cancers
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 923 | Submission Open
Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery
(This special issue belongs to the Section Clinical Research in Cancer)
Cytoskeleton in Tumor Growth and Progression
edited by David Gau
submission deadline 30 Apr 2027 | 1 articles | Viewed by 881 | Submission Open
Keywords: actin cytoskeleton; microtubules; mechano-transduction; tumor microenvironment; angiogenesis; mitochondria
(This special issue belongs to the Section Molecular Cancer Biology)
Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities
edited by , Giacomo Miserocchi and
submission deadline 30 Apr 2027 | 1 articles | Viewed by 798 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; tumor–stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models
(This special issue belongs to the Section Tumor Microenvironment)
From Metronomic Chemotherapy to Time-Optimized Cancer Treatments
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 710 | Submission Open
Keywords: metronomic chemotherapy; time-dependent treatment; chemotherapy; immunotherapy; pharmacokinetics; pharmacodynamics
Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers
edited by and Luís Ortega-Medina
submission deadline 30 Apr 2027 | Viewed by 503 | Submission Open
Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Deep Learning for Cancer Image Classification in Smaller Patient Cohorts
edited by
submission deadline 30 Apr 2027 | Viewed by 420 | Submission Open
Keywords: deep learning; deep radiomics; diagnosis; prognosis; prediction
(This special issue belongs to the Section Cancer Informatics and Big Data)
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