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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epigenetics in Endocrine-Related Cancer
edited by Jennie N Jeyapalan
submission deadline 25 Dec 2025 | 2 articles | Viewed by 3365 | Submission Open
Keywords: breast; ovarian; CRPC (castration-resistant prostate cancer); thyroid; histone modification; DNA methylation; epigenomics; chromatin; microRNAs; lncRNAs; epi-drugs
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Blood Cancers: How We Define Success submission deadline 25 Dec 2025 | 1 articles | Viewed by 2436 | Submission Open
Keywords: blood cancers; research-driven advancements; cure rates; novel agents
(This special issue belongs to the Section Cancer Therapy)
Measurable Residual Disease in Cancer: 2nd Edition
edited by Krzysztof Jamroziak and
submission deadline 25 Dec 2025 | Viewed by 195 | Submission Open
Keywords: MRD; measurable residual disease; minimal residual disease; cancer; tumor microenvironment; next generation sequencing; flow cytometry; imaging techniques
(This special issue belongs to the Section Cancer Drug Development)
Predictive Biomarkers for Lung Cancer
edited by Ole Hilberg
submission deadline 30 Dec 2025 | 10 articles | Viewed by 25436 | Submission Open
(This special issue belongs to the Section Cancer Biomarkers)
Class 2 Tumor Suppressor Gene Pathways for Therapeutic Applications in Hard-to-Treat Cancers
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5910 | Submission Open
Keywords: hard-to-treat cancers; HTT cancers; class 2 tumor suppressor genes; C2TSGs; DNA methylation driver; DNAme driver; epigenetic therapies; cancer drug development; personalized cancer therapy; tumor suppressor mimetics
(This special issue belongs to the Section Tumor Microenvironment)
Recent Advances in Hematological Malignancies in Children
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5814 | Submission Open
Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematological malignancies in children; diagnostic and therapeutic methods; supportive care strategies
(This special issue belongs to the Section Pediatric Oncology)
Understanding the Complexities of Anticancer Drugs Resistance submission deadline 30 Dec 2025 | 2 articles | Viewed by 4402 | Submission Open
(This special issue belongs to the Section Cancer Drug Development)
Transcription Factors in Breast Cancer
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 3794 | Submission Open
Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms
edited by Francesco Santullo and Agostino Maria De Rose
submission deadline 30 Dec 2025 | 2 articles | Viewed by 3047 | Submission Open
Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer
(This special issue belongs to the Section Cancer Therapy)
Palliative Radiotherapy for Cancer
edited by Rebecca Wong
submission deadline 30 Dec 2025 | 2 articles | Viewed by 2536 | Submission Open
Keywords: symptom relief; symptom control; radiation medicine; radiotheranostics; theranostics; external beam radiotherapy; palliation; oligometastases; oligoprogression; systematic reviews and meta-analyses; patient reported outcomes; abscopal effect; combined modality; education; clinical practice
(This special issue belongs to the Section Cancer Therapy)
Combination Therapy in Geriatric Population with Cancer (2nd Edition)
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2125 | Submission Open
Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials for Thoracic Cancers
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 594 | Submission Open
Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma
(This special issue belongs to the Section Clinical Research of Cancer)
Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer submission deadline 30 Dec 2025 | Viewed by 578 | Submission Open
Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity
(This special issue belongs to the Section Molecular Cancer Biology)
Insights from the Editorial Board Member
edited by
submission deadline 31 Dec 2025 | 49 articles | Viewed by 118516 | Submission Open
Keywords: cancer therapeutics; cancer biomarkers; precision medicine; cancer genomics; cancer immunology; cancer biology; clinical trials; cancer epidemiology and prevention; tumor microenvironment and metastasis; cancer informatics
Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management submission deadline 31 Dec 2025 | 19 articles | Viewed by 46458 | Submission Open
Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cervical Cancer: Screening and Treatment in 2024-2025 submission deadline 31 Dec 2025 | 8 articles | Viewed by 34156 | Submission Open
Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Disparities in Cancer Prevention, Screening, Diagnosis and Management
edited by
submission deadline 31 Dec 2025 | 17 articles | Viewed by 34118 | Submission Open
Keywords: social determinants of health (SDOH); financial toxicity; racial disparities; ethnic disparities; LGBTQIA+ disparities; cultural competency; cancer; health status disparities; healthcare disparities
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Skin Cancer: Diagnosis, Treatment and Prognosis
edited by Iris Zalaudek and
submission deadline 31 Dec 2025 | 14 articles | Viewed by 33815 | Submission Open
Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Integrating Palliative Care in Oncology submission deadline 31 Dec 2025 | 12 articles | Viewed by 33577 | Submission Open
Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
New Perspectives in the Management of Breast Cancer submission deadline 31 Dec 2025 | 12 articles | Viewed by 26503 | Submission Open
Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact
(This special issue belongs to the Section Cancer Therapy)
Advanced Diagnostics and Optical Imaging Technologies in Cancer Research
edited by Vlad Mihai Voiculescu
submission deadline 31 Dec 2025 | 12 articles | Viewed by 25745 | Submission Open
Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies
(This special issue belongs to the Section Methods and Technologies Development)
PTEN: Regulation, Signalling and Targeting in Cancer submission deadline 31 Dec 2025 | 7 articles | Viewed by 25274 | Submission Open
Keywords: PTEN; tumour suppressor; phosphatase; AKT signalling; genome integrity; apoptosis; proliferation; cancer; biomarker; precision medicine
(This special issue belongs to the Section Cancer Biomarkers)
Oral Potentially Malignant Disorders and Oral Cavity Cancer
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 23264 | Submission Open
Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine
(This special issue belongs to the Section Cancer Therapy)
Oncology: State-of-the-Art Research and Initiatives in Japan submission deadline 31 Dec 2025 | 8 articles | Viewed by 22143 | Submission Open
Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support
Novel Therapeutic Strategies in Salivary Gland Tumor submission deadline 31 Dec 2025 | 8 articles | Viewed by 20798 | Submission Open
Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging
(This special issue belongs to the Section Cancer Therapy)
Medical Imaging and Artificial Intelligence in Cancer
edited by Debiao Li and
submission deadline 31 Dec 2025 | 11 articles | Viewed by 20046 | Submission Open
Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025
edited by and David R. Gandara
submission deadline 31 Dec 2025 | 4 articles | Viewed by 19848 | Submission Open
Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Molecular Biology, Diagnosis and Management of Cervical Cancer
edited by , , Thomas Vrekoussis and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 15980 | Submission Open
Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Chronic Lymphocytic Leukaemia (CLL) Research
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 14343 | Submission Open
Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure
(This special issue belongs to the Section Cancer Therapy)
Updates in Neuroendocrine Neoplasms
edited by Jonathan Strosberg
submission deadline 31 Dec 2025 | 8 articles | Viewed by 13966 | Submission Open
Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations
(This special issue belongs to the Section Cancer Therapy)
Long-Term Cancer Survivors: Rehabilitation and Quality of Life submission deadline 31 Dec 2025 | 7 articles | Viewed by 12411 | Submission Open
Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer
edited by and Hiroshi Yaegashi
submission deadline 31 Dec 2025 | 5 articles | Viewed by 11846 | Submission Open
Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research
(This special issue belongs to the Section Tumor Microenvironment)
Robotic Surgery in Colorectal Cancer
edited by James Chi Yong Ngu
submission deadline 31 Dec 2025 | 3 articles | Viewed by 11815 | Submission Open
Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy
(This special issue belongs to the Section Clinical Research of Cancer)
Surgery for Colorectal Cancer submission deadline 31 Dec 2025 | 7 articles | Viewed by 11655 | Submission Open
Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section "Tumor Microenvironment"
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 11592 | Submission Open
Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response
(This special issue belongs to the Section Tumor Microenvironment)
The Applications of Artificial Intelligence in Gastroenterology
edited by , and Louis H. S. Lau
submission deadline 31 Dec 2025 | 3 articles | Viewed by 11197 | Submission Open
Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases
(This special issue belongs to the Section Cancer Therapy)
The Advance of Biomarker-Driven Targeted Therapies in Cancer
edited by , Qiushi Wang and Ann Bode
submission deadline 31 Dec 2025 | 5 articles | Viewed by 11082 | Submission Open
Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy
(This special issue belongs to the Section Cancer Therapy)
Advancements in Preclinical Models for Solid Cancers
edited by and Paula Dobosz
submission deadline 31 Dec 2025 | 6 articles | Viewed by 10956 | Submission Open
Keywords: solid cancers; preclinical cancer models; in vitro cancer models; in vivo cancer models; translational cancer research; strengths and limitations of preclinical cancer models
(This special issue belongs to the Section Clinical Research of Cancer)
Lymph Node Dissection for Gynecologic Cancers
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 10804 | Submission Open
(This special issue belongs to the Section Methods and Technologies Development)
Physiotherapy in Advanced Cancer and Palliative Care
edited by Nele Adriaenssens
submission deadline 31 Dec 2025 | 3 articles | Viewed by 10704 | Submission Open
Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Spine Oncology: Research and Clinical Studies
edited by Oluwaseun O. Akinduro
submission deadline 31 Dec 2025 | 8 articles | Viewed by 10703 | Submission Open
Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy
(This special issue belongs to the Section Clinical Research of Cancer)
Medical Complications and Supportive Care in Patients with Cancer (2nd Edition) submission deadline 31 Dec 2025 | 9 articles | Viewed by 9820 | Submission Open
Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets submission deadline 31 Dec 2025 | 4 articles | Viewed by 9122 | Submission Open
Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction
(This special issue belongs to the Section Cancer Biomarkers)
Unravelling Cancer Mechanism and Developing Novel Therapeutics: An Urgent Need to Treat Cancer (2nd Edition) submission deadline 31 Dec 2025 | 6 articles | Viewed by 9071 | Submission Open
Keywords: cancer; anticancer therapy; combination therapy; natural compound; nanotherapy; exosome therapy; targeted therapy; immunotherapy; chemokines; cytokines; antibodies; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 9005 | Submission Open
Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion
(This special issue belongs to the Section Cancer Biomarkers)
Technological Development for Advances in Cancer Research and Precision Oncology
edited by , and Fenglong Ma
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8927 | Submission Open
Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics
(This special issue belongs to the Section Molecular Cancer Biology)
Radiomics in Cancer
edited by Isabelle M. Germano
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8006 | Submission Open
Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy in Non-Small Cell Lung Cancers
edited by Marco Russano
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7872 | Submission Open
Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7866 | Submission Open
Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology
(This special issue belongs to the Section Methods and Technologies Development)
Ovarian Cancer Stem Cells and Tumor Microenvironment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7654 | Submission Open
Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts
(This special issue belongs to the Section Tumor Microenvironment)
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