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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Interventional Oncology in Hepatocellular Carcinoma Treatment
edited by Edward W. Lee, XiaoLi Zhu and Frank Hao
submission deadline 25 Oct 2026 | 2 articles | Viewed by 2522 | Submission Open
Keywords: hepatocellular carcinoma; interventional oncology; HCC
(This special issue belongs to the Section Cancer Therapy)
Interpretable AI and Multiomics Integration for Cancer Treatment Response Prediction: Cutting-Edge Innovations and Overcoming Challenges
edited by
submission deadline 25 Oct 2026 | Viewed by 331 | Submission Open
Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response
(This special issue belongs to the Section Methods and Technologies Development)
Skin Cancer Prevention: Strategies, Challenges and Future Directions
edited by Véronique del Marmol, Mariano Suppa, Ana-Maria Forsea and Alexander Stratigos
submission deadline 30 Oct 2026 | 8 articles | Viewed by 19029 | Submission Open
Keywords: skin cancer prevention; photoprotection; early detection; screening; epidemiology; public health; behavioral interventions; sun exposure; artificial intelligence; risk factors
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Neurofibromatosis
edited by Yunjia Chen and Yulong Fu
submission deadline 30 Oct 2026 | 2 articles | Viewed by 12347 | Submission Open
Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1
Adverse Effects During Cancer Treatment
edited by Yan Gong
submission deadline 30 Oct 2026 | 4 articles | Viewed by 4052 | Submission Open
Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Strategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 3779 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Cancer Prevention and Screening: Innovations, Implementation, and Access
edited by and Rahma S. Mkuu
submission deadline 30 Oct 2026 | 4 articles | Viewed by 3325 | Submission Open
Keywords: cancer; prevention; screening; intervention; implementation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition submission deadline 30 Oct 2026 | 2 articles | Viewed by 3179 | Submission Open
Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Gynecological Cancers: From Bench to Bedside submission deadline 30 Oct 2026 | 2 articles | Viewed by 2496 | Submission Open
Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Neurosurgery Research on Brain Tumors
edited by
submission deadline 30 Oct 2026 | 3 articles | Viewed by 2422 | Submission Open
Keywords: neuro-oncology; neurosurgical technique; brain tumors; neuroimages
Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications
edited by and Umamaheswari Natarajan
submission deadline 30 Oct 2026 | 1 articles | Viewed by 2388 | Submission Open
Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1, DNMT3A, DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Translational Insights into the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: Integrating Mechanistic, Clinical and Therapeutic Advances
edited by Ellen M. Lavoie Smith
submission deadline 30 Oct 2026 | 3 articles | Viewed by 1692 | Submission Open
Keywords: chemotherapy-induced peripheral neuropathy; mechanisms; treatment; prevention; assessment; biomarkers
Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers
edited by and
submission deadline 30 Oct 2026 | 2 articles | Viewed by 1648 | Submission Open
Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Clinical Research of Brachytherapy in Cancer
edited by Ludmiła Grzybowska-Szatkowska, and Aleksandra Kozłowska
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1346 | Submission Open
Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm
(This special issue belongs to the Section Clinical Research in Cancer)
Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research
edited by and Tamer Saad Kaoud
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1226 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research
(This special issue belongs to the Section Clinical Research in Cancer)
The Current Status of Brain Tumor Imaging: 2nd Edition
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1048 | Submission Open
Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI
(This special issue belongs to the Section Cancer Therapy)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Oct 2026 | 1 articles | Viewed by 844 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Diagnosis, Pathology and Treatment of Metastatic Brain Tumors
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 728 | Submission Open
Keywords: brain metastases; diagnostic imaging; molecular pathology; targeted therapy; immunotherapy; precision oncology; multimodal treatment; translational research
(This special issue belongs to the Section Cancer Metastasis)
Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 662 | Submission Open
Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery
MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions
edited by Wadie Mahauad Fernandez and Konstantinos V. Floros
submission deadline 30 Oct 2026 | Viewed by 624 | Submission Open
Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
The Role of Sphingolipids in Cancer Progression
edited by
submission deadline 30 Oct 2026 | Viewed by 419 | Submission Open
Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development
(This special issue belongs to the Section Molecular Cancer Biology)
Hyperthermic Intraperitoneal Chemotherapy in Oncology: Current Clinical Applications and Future Directions
edited by Konstantinos I. Votanopoulos
submission deadline 30 Oct 2026 | Viewed by 316 | Submission Open
Keywords: HIPEC; cytoreductive surgery; peritoneal surface malignancies; colorectal cancer; appendiceal neoplasms; gastric cancer; ovarian cancer; peritoneal mesothelioma; intraperitoneal chemotherapy-organoids
(This special issue belongs to the Section Cancer Therapy)
Surgical Management of Colorectal Cancer: Current Standards and Future Directions
edited by Pedro Silva-Vaz and
submission deadline 30 Oct 2026 | Viewed by 306 | Submission Open
Keywords: colorectal cancer; colorectal surgery; robotic-assisted surgery; transanal surgery; organ preservation; neoadjuvant therapy; perioperative optimization; cancer imaging; artificial intelligence; multidisciplinary approach
(This special issue belongs to the Section Cancer Therapy)
Gastrointestinal Tumors: Screening and Prevention
edited by
submission deadline 30 Oct 2026 | Viewed by 290 | Submission Open
Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy
Innovations in Pancreatic Oncology: Surgical Outcomes, Biomarkers, and Artificial Intelligence
edited by Jayasree Chakraborty and Lily Saadat
submission deadline 30 Oct 2026 | Viewed by 277 | Submission Open
Keywords: pancreatic cancer; oncology; early detection; surgical outcome; biomarkers; multi-modal data; artificial intelligenec; clinical decision support system; precision medicine
Advances in Immunotherapy, Biomarkers, and Clinical Practice in Pleural Mesothelioma and Thoracic Cancers
edited by
submission deadline 30 Oct 2026 | Viewed by 264 | Submission Open
Keywords: pleural mesothelioma; thoracic cancers; immunotherapy; biomarkers; immunotherapy resistance; molecular and genetic testing; precision oncology; real-world clinical practice
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Molecular Biomarkers in Human Testicular Germ Cell Tumors: Targets for Therapeutic, Diagnostic and Follow-Up Strategies submission deadline 30 Oct 2026 | Viewed by 240 | Submission Open
Keywords: testicular germ cell tumors (TGCTs); molecular biomarkers; miRNA; liquid biopsy; circulating tumor DNA (ctDNA); diagnostic biomarkers; therapeutic targets; follow-up/surveillance
The Applications of Artificial Intelligence in Thoracic Cancers
edited by Xin Li
submission deadline 30 Oct 2026 | Viewed by 221 | Submission Open
Keywords: artificial intelligence; biomarkers; lung cancer; machine learning; deep learning; cancer; real-world data; imaging
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Treatment Research of Acute Myeloid Leukemia (AML)
edited by Madelyn Burkart and
submission deadline 30 Oct 2026 | Viewed by 198 | Submission Open
Keywords: acute myeloid leukemia; measurable residual disease (MRD); targeted therapy; allogeneic hematopoietic stem cell transplant (HSCT); molecular diagnostics; immunotherapy
Combination Therapies for Brain Tumors
edited by Jason H. Huang and Ekokobe Fonkem
submission deadline 31 Oct 2026 | 9 articles | Viewed by 31859 | Submission Open
Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma
(This special issue belongs to the Section Cancer Therapy)
Molecular Biology, Diagnosis and Management of Endometrial Cancer
edited by , and Thomas Vrekoussis
submission deadline 31 Oct 2026 | 5 articles | Viewed by 14705 | Submission Open
Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours submission deadline 31 Oct 2026 | 6 articles | Viewed by 12931 | Submission Open
Keywords: radiomics for the diagnosis, prognostication and treatment planning of solid tumours; methods, translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition, segmentation and feature extraction); imaging methods (including CT, MRI, PET, SPECT and US)
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Combination Therapy in Lymphoma
edited by and Alberto Arribas
submission deadline 31 Oct 2026 | 4 articles | Viewed by 11990 | Submission Open
Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies, immune checkpoint inhibitors and epigenetic agents
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment of Abdominal Tumors
edited by and Ioannis Baloyiannis
submission deadline 31 Oct 2026 | 4 articles | Viewed by 11616 | Submission Open
Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal
(This special issue belongs to the Section Clinical Research in Cancer)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 31 Oct 2026 | 4 articles | Viewed by 9078 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations submission deadline 31 Oct 2026 | 5 articles | Viewed by 8580 | Submission Open
Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Cellular Heterogeneity and Plasticity in the Tumor Microenvironment submission deadline 31 Oct 2026 | 7 articles | Viewed by 8439 | Submission Open
Keywords: tumor microenvironment (TME); tumor microenvironmental heterogeneity and drug resistance; cancer cell plasticity and immune evasion; epithelial–mesenchymal transition (EMT); tumor immune context
(This special issue belongs to the Section Tumor Microenvironment)
Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models submission deadline 31 Oct 2026 | 3 articles | Viewed by 7655 | Submission Open
Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Development of Biomarkers and Antineoplastic Drugs in Solid Tumors
edited by , Sofia Verkhovskaia and Michela Roberto
submission deadline 31 Oct 2026 | 3 articles | Viewed by 7291 | Submission Open
Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence
(This special issue belongs to the Section Cancer Drug Development)
Clinical Research in Ocular Oncology
edited by Anthony B. Daniels, and
submission deadline 31 Oct 2026 | 2 articles | Viewed by 6554 | Submission Open
Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma
(This special issue belongs to the Section Clinical Research in Cancer)
Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management submission deadline 31 Oct 2026 | 2 articles | Viewed by 6495 | Submission Open
Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance
(This special issue belongs to the Section Methods and Technologies Development)
From Molecular Insights to Cancer Treatments: Progress in Translational Science
edited by , Dhanir Tailor and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 6101 | Submission Open
Keywords: cancer biology; therapeutics; molecular targets; translational research
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 5666 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy submission deadline 31 Oct 2026 | 4 articles | Viewed by 5047 | Submission Open
Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management submission deadline 31 Oct 2026 | 4 articles | Viewed by 4749 | Submission Open
Keywords: artificial intelligence; machine learning; urological oncology; imaging, precision medicine; digital pathology; therapeutic decision-making
(This special issue belongs to the Section Cancer Therapy)
Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)
edited by Shi-Ming Tu, Louis L. Pisters and
submission deadline 31 Oct 2026 | 2 articles | Viewed by 4437 | Submission Open
Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness
(This special issue belongs to the Section Cancer Pathophysiology)
Current Research in Pediatric Hematological Oncology submission deadline 31 Oct 2026 | 4 articles | Viewed by 4301 | Submission Open
Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models
(This special issue belongs to the Section Pediatric Oncology)
Combination Therapy for the Treatment of Breast Cancer
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4034 | Submission Open
Keywords: breast cancer; combination therapy; targeted therapy; immunotherapy; endocrine therapy; chemotherapy; anti-body–drug conjugates; treatment resistance; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Molecular Targets and Therapeutic Pathways in Cancer
edited by Ashish H. Shah and Deepa Seetharam
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3645 | Submission Open
Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research
(This special issue belongs to the Section Cancer Drug Development)
Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition) submission deadline 31 Oct 2026 | 3 articles | Viewed by 3293 | Submission Open
Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
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