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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Ovarian Cancer Treatment: Past, Present and Future
edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3406 | Submission Open
Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Endometrial Cancer—from Diagnosis to Management
edited by Mingxin Shi and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3272 | Submission Open
Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention
(This special issue belongs to the Section Cancer Therapy)
Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers 2nd edition
edited by and Michael D. Chuong
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3215 | Submission Open
Keywords: radiation therapy (oncology); stereotactic body radiation therapy (SBRT) and stereotactic ablative radiotherapy (SABR); ultra-hypofractionated and hypofractionated studies; ablative/dose-escalated studies; SBRT; SABR; and cyberknife technology; MRI guidance; tumor motion techniques and management; frame and frameless immobilization devices; SBRT/SABR dose constraints and toxicities; artificial intelligence/machine learning
(This special issue belongs to the Section Cancer Therapy)
Burkitt Lymphoma: From Pathogenesis to Current Treatments
edited by Lorenzo Leoncini and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2981 | Submission Open
Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Chemotherapy and Immunotherapy of Lung Cancer
edited by and Klaus Hackner
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2980 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer
(This special issue belongs to the Section Cancer Therapy)
Fertility Preservation in Gynecological Cancer submission deadline 31 Dec 2025 | 2 articles | Viewed by 2893 | Submission Open
Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication
(This special issue belongs to the Section Methods and Technologies Development)
Innovations in Addressing Disparities in Cancer submission deadline 31 Dec 2025 | 1 articles | Viewed by 2891 | Submission Open
Keywords: artificial intelligence on health equity; artificial intelligence and machine learning technologies in cancer care; genomic testing and biomarkers; AI in social determinants of health; health justice; precision medicine and health informatics; innovative cancer care delivery model for overcoming health disparity; equity lens; racial differences in the immunological landscape; racial differences in treatment and disease outcome
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Palliative Care and Pain Management in Cancer
edited by María Fernández-Gonzáles and Moira O'Connor
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2867 | Submission Open
Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Novel Therapeutic Targets for Metastatic Lung Cancer
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2833 | Submission Open
Keywords: metastatic lung cancer; targeted therapy; immunotherapy; resistance mechanisms; tumor microenvironment; biomarkers; novel drug targets; translational oncology; precision medicine; epigenetic modulation
(This special issue belongs to the Section Cancer Therapy)
Sarcoma Management in Orthopaedic Oncology
edited by and Jendrik Hardes
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2798 | Submission Open
Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Oral Cancer: Prevention and Early Detection (2nd Edition) submission deadline 31 Dec 2025 | 1 articles | Viewed by 2756 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
New Insights into Kidney Disease Development and Therapy Strategies submission deadline 31 Dec 2025 | 1 articles | Viewed by 2602 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology
edited by An Liu, Bin Cai and Murat Surucu
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2567 | Submission Open
Keywords: advanced imaging techniques; adaptive radiotherapy; computational models
(This special issue belongs to the Section Methods and Technologies Development)
Technical and Technological Innovations in Head and Neck Cancer Surgery
edited by Marta Filauro
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2556 | Submission Open
Keywords: head and neck; squamous cell carcinoma; larynx; oral cavity; free flap; exoscope; TORS
(This special issue belongs to the Section Methods and Technologies Development)
New Insights into Microbial-Based Cancer Therapy
edited by Amitabha Ray
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2496 | Submission Open
Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Therapy)
Radioimmunotherapy, Neoadjuvant Immunotherapy, and Adjuvant Immunotherapy for Cancer submission deadline 31 Dec 2025 | 1 articles | Viewed by 2315 | Submission Open
Keywords: immunotherapy; radioimmunotherapy; neoadjuvant immunothearpy; radiopharmaceuticals
(This special issue belongs to the Section Cancer Therapy)
Advances in the Molecular Biology of Sarcoma and Drug Development
edited by Francis Hornicek and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2138 | Submission Open
Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape
edited by Jon Mallen-St Clair
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2052 | Submission Open
Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Lymphoma Biology, Pathology and Stem Cells
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1975 | Submission Open
Keywords: lymphoma biology; pathology; CAR-T; immunotherapy; stem cell transplant
(This special issue belongs to the Section Cancer Pathophysiology)
Surgical Innovations in Advanced Gastric Cancer
edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1908 | Submission Open
Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management
(This special issue belongs to the Section Cancer Therapy)
Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside
edited by Shuhang Wang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1892 | Submission Open
Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study
(This special issue belongs to the Section Cancer Therapy)
New Insights in the Management of Resectable Esophageal Malignancy
edited by and Dimitrios A. Theodorou
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1891 | Submission Open
Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in the Section “Cancer Therapy” in 2025
edited by , Qiang Wang and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1836 | Submission Open
Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Peritoneal Carcinomatosis
edited by Neda Dadgar and Patrick L. Wagner
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1804 | Submission Open
Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid
(This special issue belongs to the Section Clinical Research of Cancer)
Molecular Pathology and Human Cancers
edited by Stefano Marletta, Alessandro Russo and Giuliana Pavone
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1789 | Submission Open
Keywords: molecular pathology; cancer pathogenesis; targeted therapy; personalized medicine; cancer signaling
(This special issue belongs to the Section Cancer Pathophysiology)
Challenges and New Developments in the Diagnosis and Treatment of Sarcoma
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1787 | Submission Open
Keywords: bone and soft tissue sarcoma; prognostic and predictive biomarker; transcriptomic/genomic profiling; immunotherapy; targeted treatment
(This special issue belongs to the Section Cancer Therapy)
Advanced Ovarian Cancer (2nd Edition)
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1770 | Submission Open
Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy
(This special issue belongs to the Section Cancer Therapy)
New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1650 | Submission Open
Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
(This special issue belongs to the Section Cancer Therapy)
Chromatin-Remodeling Factors in Cancer Cells
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1496 | Submission Open
Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies
(This special issue belongs to the Section Cancer Pathophysiology)
Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1485 | Submission Open
Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis submission deadline 31 Dec 2025 | 1 articles | Viewed by 1445 | Submission Open
Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1400 | Submission Open
Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma
(This special issue belongs to the Section Cancer Pathophysiology)
Innovations in Microsurgical Techniques for Breast Cancer Reconstruction
edited by and Robert J. Allen
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1326 | Submission Open
Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair
(This special issue belongs to the Section Methods and Technologies Development)
Accelerated Partial Breast Irradiation
edited by Roxolyana Abdah-Bortnyak
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1312 | Submission Open
Keywords: radiotherapy; accelerated partial breast irradiation; breast cancer; intraoperative radiotherapy; external beam radiotherapy; brachytherapy
(This special issue belongs to the Section Cancer Therapy)
Cutaneous Metastases: State-of-the-Art Research and Management
edited by Marios N. Papadakis and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1311 | Submission Open
Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes
(This special issue belongs to the Section Cancer Metastasis)
Breast Cancer Research and Treatment
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1187 | Submission Open
Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Emerging Concepts in Mesothelioma
edited by Georgios T. Stathopoulos and Tonia Adamides
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1105 | Submission Open
Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 759 | Submission Open
Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening
(This special issue belongs to the Section Cancer Drug Development)
Facial Paralysis in Cancer Patients—from Diagnosis to Treatment and Facial Reanimation
edited by , Niels van Heerbeek, Giulia Molinari and Benedikt Hofauer
submission deadline 31 Dec 2025 | Viewed by 552 | Submission Open
Keywords: facial nerve; facial nerve reanimation; head and neck cancer; facial reconstructive surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advanced Research in Surgical Treatment for Spinal Tumors
edited by Alessandro Gasbarrini, Stefano Bandiera and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 521 | Submission Open
Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy
(This special issue belongs to the Section Cancer Therapy)
Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)
edited by Erlinda M. Gordon, and Frederick L. Hall
submission deadline 31 Dec 2025 | Viewed by 423 | Submission Open
Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy
edited by Antonio Pontoriero
submission deadline 31 Dec 2025 | Viewed by 370 | Submission Open
Keywords: SBRT; gynecologic cancer; chemoradiotherapy; immunotherapy; oligometastatic; oligoecurrent; oligopersistent; reirradiation
(This special issue belongs to the Section Cancer Therapy)
Views and Perspectives of Robot-Assisted Liver Surgery (2nd Edition)
edited by , Ibrahim Dagher and
submission deadline 31 Dec 2025 | Viewed by 350 | Submission Open
Keywords: robotic; liver surgery; liver resection; hepatectomy; minimally invasive; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Advances in the Pathogenesis of Hematopoietic Neoplasms submission deadline 31 Dec 2025 | Viewed by 348 | Submission Open
Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment
(This special issue belongs to the Section Cancer Pathophysiology)
Surgical Aspects of Ovarian/Tubal/Peritoneal Cancer Management submission deadline 31 Dec 2025 | Viewed by 343 | Submission Open
Keywords: primary cytoreduction; interval cytoreduction; neoadjuvant chemotherapy
(This special issue belongs to the Section Cancer Therapy)
Research Challenges in Adolescent and Young Adult Cancer
edited by and Jeremy Lewin
submission deadline 31 Dec 2025 | Viewed by 312 | Submission Open
Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers
(This special issue belongs to the Section Pediatric Oncology)
Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer
edited by Tim Strate and
submission deadline 31 Dec 2025 | Viewed by 262 | Submission Open
Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC
(This special issue belongs to the Section Cancer Therapy)
The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes submission deadline 31 Dec 2025 | Viewed by 257 | Submission Open
Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment
(This special issue belongs to the Section Clinical Research of Cancer)
Artificial Intelligence (AI), Robotics, and Cancer Surgery
edited by Zaid M. Abdelsattar
submission deadline 31 Dec 2025 | Viewed by 239 | Submission Open
Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making
(This special issue belongs to the Section Methods and Technologies Development)
Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas submission deadline 31 Dec 2025 | Viewed by 233 | Submission Open
Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor
(This special issue belongs to the Section Pediatric Oncology)
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