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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advancing Clinical Care and Therapeutics

edited by

Benjamin D. Powers

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1145 | Submission Open

Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases

(This special issue belongs to the Section Cancer Therapy)

Advances in Cancer Targeted Therapy

edited by Ponniah Selvakumar

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1124 | Submission Open

Keywords: targeted therapy; cancer treatment; molecular targets; signaling pathways; angiogenesis inhibition; artificial intelligence (AI); single-cell technologies; informatics; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

The Molecular Mechanisms of DNA Replication and Repair

edited by Taru Muranen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: DNA replication; DNA repair; double helix; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Computational Cancer Biology: Machine Learning for Multi-Omics Integration and Prognosis

edited by Aftab Alam

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1093 | Submission Open

Keywords: multi-omics integration; computational oncology; prognostic biomarkers; machine learning; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Translational Advances in Reproductive Cancers: From Targets to Therapies

edited by

Kamila Domińska

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1076 | Submission Open

Keywords: reproductive cancers; signal transduction pathways; hormonal regulation; targeted therapy; therapeutic limitations

(This special issue belongs to the Section Molecular Cancer Biology)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1045 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Biomarkers in the Management of Gynecological Cancer

edited by Ferenc Bánhidy,

Keszthelyi Márton

and Balázs Lintner

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1025 | Submission Open

Keywords: gynecologic cancer; biomarkers; cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; diagnostic biomarkers; prognostic biomarkers; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Recent Advances in Myeloma: From Molecular Pathways to Drug Development

edited by Natalia Neparidze

submission deadline 30 Sep 2026 | 1 articles | Viewed by 904 | Submission Open

Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD

(This special issue belongs to the Section Cancer Drug Development)

Advances in Natural Compounds for Cancers

edited by

Nađa Grozdanić Stanisavljević

and Milica Nedeljković

submission deadline 30 Sep 2026 | 1 articles | Viewed by 879 | Submission Open

Keywords: natural compounds; anticancer activity; molecular mechanisms; synergistic effects; radiosensitizers; radioprotectors; organoids and 3D models; in vivo studies; 2D cell culture; drug resistance

(This special issue belongs to the Section Cancer Drug Development)

Head and Neck Cancer Therapies: Current and Innovative Options

edited by

Ye Guo

submission deadline 30 Sep 2026 | 1 articles | Viewed by 857 | Submission Open

Keywords: head and neck cancer; multimodal therapy; precision oncology; immunotherapy; antibody–drug conjugates; bispecific antibodies; HPV; salivary gland cancers and sinonasal carcinomas

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Microenvironment: Molecular Mechanisms and Therapeutic Targeting

edited by Yi Fang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 855 | Submission Open

Keywords: breast cancer; tumor microenvironment; biomarkers; therapeutic targeting; tumor-stromal interactions; precision oncology

(This special issue belongs to the Section Tumor Microenvironment)

Strategies and Techniques in Diagnosing, Treating and Surveying Sarcoma

edited by H. Thomas Temple

submission deadline 30 Sep 2026 | 1 articles | Viewed by 782 | Submission Open

Keywords: sarcoma; diagnosis; therapy; treatment; surgery; molecular; radiomics

Risk-Stratified Colorectal Cancer Screening and Surveillance

edited by

Molla Wassie

submission deadline 30 Sep 2026 | 1 articles | Viewed by 773 | Submission Open

Keywords: colorectal cancer; risk stratification; colonoscopy; advanced colorectal neoplasia; precision prevention

New Clinical Insights into Gynecological Malignancies

edited by

Amelia Jernigan

submission deadline 30 Sep 2026 | 2 articles | Viewed by 723 | Submission Open

Keywords: innovative care; data science; precision medicine; uterine cancer; ovarian cancer; vulvar cancer; vaginal cancer

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Reconstruction and Surgery for Breast Cancer

edited by

Gilles Houvenaeghel

submission deadline 30 Sep 2026 | 1 articles | Viewed by 694 | Submission Open

Keywords: breast cancer; reconstruction; breast surgery; axillary surgery; sentinel lymph node; neoadjuvant chemotherapy; autologous fat transfer; breast implant

Radiation Therapy for Meningiomas

edited by Helen A. Shih and Lia M. Halasz

submission deadline 30 Sep 2026 | 1 articles | Viewed by 636 | Submission Open

Keywords: radiation therapy; proton radiation; particle therapy; theranostics; brachytherapy; molecular features; advance imaging; late toxicities; quality of life

(This special issue belongs to the Section Cancer Therapy)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 30 Sep 2026 | Viewed by 595 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research in Cancer)

Current Treatments of Esophageal and Esophagogastric Junction Cancers (2nd Edition)

edited by

Masanobu Nakajima

submission deadline 30 Sep 2026 | 1 articles | Viewed by 595 | Submission Open

Keywords: esophageal cancer; esophagogastric junction cancer; endoscopic resection; surgery; minimally invasive surgery; robotic surgery; chemotherapy; chemoradiotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

Flow Cytometry and Beyond: Innovative Cytometric Approaches in Cancer Detection, Profiling, and Therapeutic Monitoring

edited by

George Vartholomatos

Georgios Markopoulos

, Lefkothea Dova and Savvas Dimitriadis

submission deadline 30 Sep 2026 | Viewed by 505 | Submission Open

Keywords: cancer diagnostics; next-generation flow cytometry; AI-driven cytometry; high-dimensional single-cell analysis; cancer immunophenotyping; cytometry-based biomarkers; tumor heterogeneity; extracellular vesicles; spectral and mass cytometry; intraoperative flow cytometry

(This special issue belongs to the Section Methods and Technologies Development)

Translational Biomarkers in Solid Tumors: From Diagnosis to Therapy

edited by

Konrad Steinestel

and

Andreea-Raluca Cozac-Szoke

submission deadline 30 Sep 2026 | Viewed by 499 | Submission Open

Keywords: cancer biomarkers; solid tumors; precision oncology; translational research; tumor heterogeneity; primary vs. metastatic disease; therapeutic stratification

Extracellular Matrix Proteins in Cancer (2nd Edition)

edited by

Dragana Nikitovic

and Aikaterini Berdiaki

submission deadline 30 Sep 2026 | Viewed by 450 | Submission Open

Keywords: extracellular matrix (ECM); tumor microenvironment (TME); stromal remodeling; cancer-associated fibroblasts (CAFs); fibrous proteins; mechanotransduction; interstitial fluid pressure; proteoglycans and glycoproteins; matrix crosslinking; epithelial-to-mesenchymal transition (EMT); angiogenesis; matrikines; therapy resistance

(This special issue belongs to the Section Tumor Microenvironment)

Integrated Palliative Care in Advanced Cancer

edited by

Sebastiano Mercadante

submission deadline 30 Sep 2026 | Viewed by 450 | Submission Open

Keywords: integrated palliative care; advanced cancer; cancer pain; symptom management; early integration; supportive care; end-of-life care; patient-centered outcomes; tele-palliative care; refractory symptoms

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Metastasis in Tumor Immunity: Current Perspectives

edited by

Ulrike Stein

, Sebastian Torke and

Wolfgang Walther

submission deadline 30 Sep 2026 | Viewed by 427 | Submission Open

Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints

(This special issue belongs to the Section Cancer Metastasis)

Radiation Therapy in Lung Tumors: Recent Trends and Current Issues

edited by

Paul Jules van Houtte

and Sara Ramella

submission deadline 30 Sep 2026 | Viewed by 409 | Submission Open

Keywords: lung cancer; immunotherapy; chemotherapy; PET-CT; surgery; oligo-metastases

(This special issue belongs to the Section Cancer Therapy)

Health-Related Quality of Life in Cancer Survivorship

edited by Deniz Gencer and Elisabeth Coyne

submission deadline 30 Sep 2026 | Viewed by 404 | Submission Open

Keywords: cancer survivorship; health-related quality of life (HRQoL); interventions; psychological support; personalized care; educational resources

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications

edited by

Spiros Vlahopoulos

submission deadline 30 Sep 2026 | Viewed by 379 | Submission Open

Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma

(This special issue belongs to the Section Tumor Microenvironment)

Medical Image-Based Cervical Cancer Prevention, Diagnosis, and Treatment

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 30 Sep 2026 | Viewed by 369 | Submission Open

Keywords: medical imaging; 3-dimensional imaging; cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Redefining Precision Radiotherapy

edited by Srinivasan Vijayakumar

submission deadline 30 Sep 2026 | Viewed by 365 | Submission Open

Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics

(This special issue belongs to the Section Methods and Technologies Development)

Non-Coding RNAs in Cancer: Molecular Diagnostics and RNA-Based Therapeutics

edited by

Andreas Scorilas

and

Marios A. Diamantopoulos

submission deadline 30 Sep 2026 | 1 articles | Viewed by 364 | Submission Open

Keywords: ncRNAs; miRNAs; lncRNAs; snoRNAs; regulatory RNAs; housekeeping RNAs; cancer biomarkers; RNA-targeted approaches; predictive markers; therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy

edited by

Soumen Saha

submission deadline 30 Sep 2026 | Viewed by 356 | Submission Open

Keywords: nanomedicine; tumor-targeting mechanisms; cancers

(This special issue belongs to the Section Tumor Microenvironment)

PSMA Targeted Strategies and Radioligand Therapies in Prostate Cancer: From Preclinical Models to Clinical Translation

edited by Neha Vapiwala and John Nikitas

submission deadline 30 Sep 2026 | Viewed by 349 | Submission Open

Keywords: prostate cancer; prostate-specific membrane antigen; radioligand therapy; radiopharmaceutical therapy; radiotherapy; theranostics

(This special issue belongs to the Section Cancer Therapy)

CRLM in the Era of Transplant Oncology: New Hope, New Questions

edited by Brian Davidson and

Khurum Khan

submission deadline 30 Sep 2026 | Viewed by 336 | Submission Open

Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Trials and Precision Medicine for Neuro-Oncology

edited by Malaka Ameratunga

submission deadline 30 Sep 2026 | Viewed by 327 | Submission Open

Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine

(This special issue belongs to the Section Clinical Research in Cancer)

Advances in Combination Therapy for Lymphoma

edited by

Maria Christina Cox

submission deadline 30 Sep 2026 | Viewed by 325 | Submission Open

Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs

(This special issue belongs to the Section Cancer Therapy)

New Era of Systemic Therapy for Different Types of Skin Cancer

edited by Magdalena Ciazynska

submission deadline 30 Sep 2026 | Viewed by 308 | Submission Open

Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer and Environmental Exposure: Unveiling Latest Insights and Future Directions

edited by

Dimitra Koumaki

submission deadline 30 Sep 2026 | Viewed by 307 | Submission Open

Keywords: skin cancer; melanoma; non-melanoma skin cancer; environmental factors; ultraviolet (UV) radiation; DNA damage; etiology; prevention and treatment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Next-Generation Cancer Research: AI Approaches for Biomarkers, Therapeutics and Beyond

edited by Wen Zhang

submission deadline 30 Sep 2026 | Viewed by 303 | Submission Open

Keywords: computational genetics; cancer; big data analysis; deep learning; statistical modeling; bioinformatics; AI; biomarkers; therapeutics

(This special issue belongs to the Section Cancer Informatics and Big Data)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Sep 2026 | Viewed by 302 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Roles of Circular RNAs (circRNAs) in Cancer Development and Progression

edited by

Qubo Zhu

submission deadline 30 Sep 2026 | Viewed by 289 | Submission Open

Keywords: circular RNAs (circRNAs); cancer development; tumor progression; oncogenesis; gene regulation; metastasis; tumor microenvironment; therapeutic targets; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Cancer Biology)

The Evolving Landscape of Endometrial Cancer

edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis

submission deadline 30 Sep 2026 | Viewed by 288 | Submission Open

Keywords: endometrial cancer; patient quality of life; fertility preservation; molecular classification; minimal invasive surgery; emerging therapeutic approaches

(This special issue belongs to the Section Molecular Cancer Biology)

Metabolomics Approaches in Cancer Diagnosis

edited by

Raj Kumar Sharma

submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open

Keywords: metabolomics; metabolites; NMR metabolomics; mass spectrometry in metabolomics; cancer biomarkers; metabolomics methods

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Non-Melanoma Skin Cancer: A Growing Problem in the Elderly Population

edited by Jolanta Jaworek and Dariusz Kowalczyk

submission deadline 30 Sep 2026 | Viewed by 276 | Submission Open

Keywords: NMSC; pathomechanism of NMSC; NMSC and gut and/or skin microbiota; NMSC treatment; NMSC diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advanced Multimodal Neuroimaging and Computational Approaches in Brain Tumor Research

edited by

Feng Liu

submission deadline 30 Sep 2026 | Viewed by 272 | Submission Open

Keywords: brain tumors; multimodal neuroimaging; artificial intelligence; radiomics; imaging genomics; diffusion MRI; functional MRI; precision oncology

Leukemia Stem Cells: Persistence, Resistance, and Novel Eradication Strategies

edited by Elisa Donato and Darja Karpova

submission deadline 30 Sep 2026 | Viewed by 269 | Submission Open

Keywords: leukemia stem cells (LSCs); acute myeloid leukemia (AML); therapeutic resistance; minimal residual disease (MRD); LSC quiescence; cellular therapy; hematopoietic stem cell transplantation (HSCT); LSC microenvironment

Tumor Microenvironment in Hematological Malignancies: Advances in Targeted Therapies and Cellular Mechanisms

edited by Carolina Simioni

submission deadline 30 Sep 2026 | Viewed by 253 | Submission Open

Keywords: hematological malignancies; tumor microenvironment; bone marrow niche; targeted therapy; signal transduction; drug resistance; tumor metabolism; cell plasticity; biomarkers; cell–cell interactions

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Clinical Pharmacology in Lung Cancer—2nd Edition

edited by

Chih-Jen Yang

submission deadline 30 Sep 2026 | Viewed by 253 | Submission Open

Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS

(This special issue belongs to the Section Cancer Drug Development)

Pancreatic Cancer Ultrasound: A Problem-Based Approach

edited by

Carla Serra

and Andrea Boccatonda

submission deadline 30 Sep 2026 | Viewed by 252 | Submission Open

Keywords: cancer; ultrasound; pancreas; CEUS; malignancy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advancements in Cervical Cancer Screening and HPV-Related Disease Management

edited by

Maria Lina Tornesello

submission deadline 30 Sep 2026 | Viewed by 244 | Submission Open

Keywords: cervical cancer; cervical intraepithelial neoplasia; HPV (human papillomavirus); cervical cancer screening; high-resolution colposcopy; DNA methylation; HPV genotyping; HPV vaccination; molecular diagnostics; self-sampling; biomarkers; immune response; Ai-assisted screening; cervical cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Conventional and AI-Enabled Precision Medicine/Surgery in Oncology

edited by

Georgios Antonios Margonis

and Dimitris Bertsimas

submission deadline 30 Sep 2026 | Viewed by 242 | Submission Open

Keywords: precision medicine; precision surgery; surgical oncology; treatment effect heterogeneity; subgroup discovery; causal inference; real-world evidence; confounding; interpretable AI; clinical decision support

(This special issue belongs to the Section Cancer Informatics and Big Data)

Targeted Therapy for Colorectal Cancer

edited by

Rajat Bhattacharya

submission deadline 30 Sep 2026 | Viewed by 239 | Submission Open

Keywords: colorectal cancer; targeted therapy; combination therapy; novel inhibitors; immune targeting; overcoming resistance

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