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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical and Translational Research in Hematological Malignancies

edited by

Elaine Yee Lin Chung

submission deadline 20 Sep 2025 | Viewed by 105 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoblastic leukemia (ALL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); multiple myeloma (MM); CAR-T; antibody– drug conjugate (ADC); venetoclax; FLT3 inhibitors; IDH inhibitors

(This special issue belongs to the Section Clinical Research of Cancer)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 23 Sep 2025 | Viewed by 211 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Rare Breast Tumors

edited by

Maggie Banys-Paluchowski

and

Maria Luisa Gasparri

submission deadline 25 Sep 2025 | 7 articles | Viewed by 10730 | Submission Open

Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer

(This special issue belongs to the Section Cancer Therapy)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 25 Sep 2025 | 1 articles | Viewed by 931 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Genomics and Transcriptomics in Sarcoma

edited by George Jour and Jose G. Mantilla

submission deadline 25 Sep 2025 | 1 articles | Viewed by 795 | Submission Open

Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Clinical Surgery for Gynecological Cancers

edited by

Sebastian Szubert

submission deadline 25 Sep 2025 | 1 articles | Viewed by 732 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; gynecological surgery; gynecological oncology; reconstructive surgery; pelvic exenteration; supportive cancer care

(This special issue belongs to the Section Methods and Technologies Development)

Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies

edited by

Ramses Forsyth

and

Pancras Hogendoorn

submission deadline 30 Sep 2025 | 11 articles | Viewed by 31217 | Submission Open

Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma

(This special issue belongs to the Section Molecular Cancer Biology)

State of the Art and New Approaches to Spinal Cord Tumors

edited by Cédric Y. Barrey and Gabriele Capo

submission deadline 30 Sep 2025 | 8 articles | Viewed by 23723 | Submission Open

Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors

(This special issue belongs to the Section Methods and Technologies Development)

Gynecologic Cancer: Risk Factors, Interception and Prevention

edited by Brandy Heckman-Stoddard and Goli Samimi

submission deadline 30 Sep 2025 | 8 articles | Viewed by 16437 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Novel Approaches and Advances in Interventional Oncology

edited by

Thomas Vogl

and

Hamzah Adwan

submission deadline 30 Sep 2025 | 11 articles | Viewed by 13685 | Submission Open

Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Sep 2025 | 7 articles | Viewed by 12275 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

Patient-Centered Outcomes of Colorectal Cancer Surgery

edited by Ira L. Leeds and Zhaomin Xu

submission deadline 30 Sep 2025 | 7 articles | Viewed by 12203 | Submission Open

Keywords: colorectal cancer; quality of life; postoperative outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2025 | 4 articles | Viewed by 11983 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art

edited by Jakub Dobruch

submission deadline 30 Sep 2025 | 6 articles | Viewed by 8196 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Methods and Technologies Development)

Urogenital Neoplasms Pathology

edited by

Carlo Introini

submission deadline 30 Sep 2025 | 4 articles | Viewed by 6675 | Submission Open

Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy

(This special issue belongs to the Section Cancer Pathophysiology)

Feature Review Paper Special Issue in Section Molecular Cancer Biology

edited by

Donat Kögel

submission deadline 30 Sep 2025 | 3 articles | Viewed by 6639 | Submission Open

Keywords: molecular biology; cell biology; cancer; tumor; cancer cell

(This special issue belongs to the Section Molecular Cancer Biology)

Monoclonal Antibodies in Lymphoma

edited by Donato Mannina

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5788 | Submission Open

Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours

edited by Alan Jackson

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4696 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research

edited by Yutaro Kato

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4356 | Submission Open

Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology

(This special issue belongs to the Section Cancer Therapy)

Current Use of Hematopoietic Cell Transplantation in Hematologic Malignancies

edited by Marina Díaz-Beyá and Maria Queralt Salas

submission deadline 30 Sep 2025 | 4 articles | Viewed by 3425 | Submission Open

Keywords: allogeneic hematopoietic cell transplantation; hematologic malignancies; minimal residual disease; patient selection; conditioning regimens; graft-versus-host disease prophylaxis; immunotherapy; targeted treatments; real-world data; acute myeloid leukemia; myelodysplastic syndrome; chronic myelomonocytic leukemia; allogeneic hematopoietic cell transplantation

(This special issue belongs to the Section Transplant Oncology)

Adjuvant Therapy for Pancreatic Cancer

edited by Sonam Kumari

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2919 | Submission Open

Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma

(This special issue belongs to the Section Cancer Therapy)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2890 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2797 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research of Cancer)

Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting

edited by

Jürgen C. Becker

Nicole Fischer

, John Paoli and

Weng-Onn Lui

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2502 | Submission Open

Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Systematic Reviews and Meta-Analyses of Genitourinary Cancers (2nd Edition)

edited by

Giorgio Treglia

and Ursula Maria Vogl

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2485 | Submission Open

Keywords: systematic review; meta-analysis; oncology; genitourinary cancers; diagnosis; therapy

(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)

Cancer Risk Factors and Prognosis in Transplant Patients

edited by

Georgios Tsoulfas

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2183 | Submission Open

Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2028 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms

edited by Anna Caterina Milanetto and

Claudio Pasquali

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1503 | Submission Open

Keywords: pancreatic neuroendocrine neoplasms; CT scan; MRI; PET/CT; target therapy; radioligand therapy; chemotherapy; microwave ablation; radiofrequency ultrasound ablation; hepatic arterial embolization

(This special issue belongs to the Section Cancer Therapy)

Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)

edited by Monzr M. Al-Malki

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1474 | Submission Open

Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Systemic Therapy and Radiotherapy for the Treatment of Lung Cancer

edited by Gaurav Marwaha

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1354 | Submission Open

Keywords: chemoradiation; targeted therapy; immunotherapy; oligometastases; SBRT; biomarkers; NSCLC; small-cell lung cancer; PCI

(This special issue belongs to the Section Cancer Therapy)

AI-Driven Oncology: Advancing Cancer Detection, Diagnosis, and Personalized Treatment

edited by

Mohamed Shehata

and

Fatma M. Talaat

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1340 | Submission Open

Keywords: cancer detection and diagnosis; AI in oncology; explainable AI (XAI); precision oncology; medical imaging; prognostic biomarkers; clinical decision support systems

(This special issue belongs to the Section Methods and Technologies Development)

Tumor Microenvironment Dynamics in Hepatocellular Carcinoma

edited by Joseph Franses and Adam Burgoyne

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1228 | Submission Open

Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions

(This special issue belongs to the Section Tumor Microenvironment)

Multiple Myeloma—Biology, Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Cirino Botta

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1056 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; minimal residual disease; mass spectrometry; flow cytometry; CAR-T; bispecific agents; genomic alterations

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advanced Research on Radioresistant Tumors

edited by Mansoor M. Ahmed and Kamila Rawojć

submission deadline 30 Sep 2025 | 1 articles | Viewed by 703 | Submission Open

Keywords: radioresistant tumors; radiotherapy innovations; proton and heavy ion therapy; immunotherapy and radiotherapy combinations; genetic biomarkers; tumor hypoxia; combination treatment strategies; molecular oncology

(This special issue belongs to the Section Cancer Therapy)

Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response, 2nd Edition

edited by

Daniela De Totero

and

Paolo Giannoni

submission deadline 30 Sep 2025 | 1 articles | Viewed by 653 | Submission Open

Keywords: chronic lymphocytic leukemia; tumor microenvironment; cytokines targeted therapy; combination therapy; 2D/3D models of CLL– tumor microenviroment

(This special issue belongs to the Section Tumor Microenvironment)

EGFR Signaling in Cancer (2nd Edition)

edited by

Xiaoping Wang

and

Naoto T. Ueno

submission deadline 30 Sep 2025 | Viewed by 540 | Submission Open

Keywords: epidermal growth factor receptor (EGFR); tumor microenvironment; drug resistance; clinical trial; cell signaling

(This special issue belongs to the Section Molecular Cancer Biology)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 30 Sep 2025 | Viewed by 405 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Actin Binding Proteins in Cancer Progression

edited by Partha Roy

submission deadline 30 Sep 2025 | 1 articles | Viewed by 373 | Submission Open

Keywords: actin binding proteins; cancer biology; cell migration; angiogenesis; signaling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 30 Sep 2025 | Viewed by 322 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

Advances in Antibody–Drug Conjugates (ADCs) in Cancers

edited by

Jayanth Panyam

submission deadline 30 Sep 2025 | Viewed by 309 | Submission Open

Keywords: antibody– drug conjugates (ADCs); therapeutic efficacy; drug delivery; structural features; disposition; linker design; payload optimization

(This special issue belongs to the Section Cancer Drug Development)

Molecular Genomics in Brain Tumors

edited by

Marta Mellai

and

Renzo Boldorini

submission deadline 30 Sep 2025 | Viewed by 288 | Submission Open

Keywords: glioma; signaling pathways; metabolism; microbiota– gut– brain axis; biomarkers; therapeutics; immunotherapy

(This special issue belongs to the Section Cancer Pathophysiology)

Advancements and Treatment Strategies for Central Nervous System Malignancies and Cancer Stem Cells

edited by Mingli Liu

submission deadline 30 Sep 2025 | Viewed by 284 | Submission Open

Keywords: central nervous system; signaling pathways; cancer stem cells; biomarker; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer

edited by Daniel Martin

submission deadline 30 Sep 2025 | Viewed by 282 | Submission Open

Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy

(This special issue belongs to the Section Cancer Therapy)

The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications

edited by

Mariarosaria Conte

submission deadline 30 Sep 2025 | Viewed by 252 | Submission Open

Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application

(This special issue belongs to the Section Tumor Microenvironment)

Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)

edited by Hiromichi Ito

submission deadline 30 Sep 2025 | Viewed by 246 | Submission Open

Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Peritoneal Carcinomatosis

edited by Neda Dadgar and Patrick L. Wagner

submission deadline 30 Sep 2025 | Viewed by 243 | Submission Open

Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid

(This special issue belongs to the Section Clinical Research of Cancer)

Melanoma: Pathology and Translational Research—2nd Edition

edited by

Alessio Giubellino

Carlos Torres-Cabala

and Jose A. Plaza

submission deadline 30 Sep 2025 | Viewed by 222 | Submission Open

Keywords: melanoma; histopathology; dermatopathology; molecular profiling; biomarkers; digital pathology; translational studies; cancer therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Artificial Intelligence Supporting Global Cancer Statistics: Incidence and Mortality

edited by Margherita Ferrante and

Gea Oliveri Conti

submission deadline 30 Sep 2025 | Viewed by 215 | Submission Open

Keywords: artificial intelligence; big data; cancer statistics; oncological prevention; incidence; mortality

(This special issue belongs to the Section Methods and Technologies Development)

Radiation Therapy in Lung Cancer: From a Technical Revolution to a Combination with New Systemic Approaches (2nd Edition)

edited by

Alessio Bruni

submission deadline 30 Sep 2025 | Viewed by 210 | Submission Open

Keywords: NSCLC; SCLC; radiation therapy; SBRT; adjuvant RT; immunotherapy; concomitant treatments; toxicities

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)

edited by

Erel Joffe

submission deadline 30 Sep 2025 | Viewed by 208 | Submission Open

Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Displaying special issue 201-250 on page 5 of 23.

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