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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting RNA to Improve Cancer Precision Medicine
edited by , Anna Grimaldi and Chiara Tammaro
submission deadline 30 Sep 2026 | Viewed by 470 | Submission Open
Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging
edited by
submission deadline 30 Sep 2026 | Viewed by 128 | Submission Open
Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management
edited by and Stefan Haider
submission deadline 30 Sep 2026 | Viewed by 98 | Submission Open
Keywords: machine learning; radiomics; cancer imaging; malignancy; survival
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)
edited by and Kanae Taruno
submission deadline 30 Sep 2026 | Viewed by 93 | Submission Open
Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level
(This special issue belongs to the Section Tumor Microenvironment)
Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications
edited by
submission deadline 30 Sep 2026 | Viewed by 80 | Submission Open
Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma
(This special issue belongs to the Section Tumor Microenvironment)
Medical Image-Based Cervical Cancer Prevention, Diagnosis and Treatments
edited by Emma R. Allanson and Ming Yin Lin
submission deadline 30 Sep 2026 | Viewed by 58 | Submission Open
Keywords: medical imaging; 3-dimensional imaging; cervical cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives submission deadline 30 Sep 2026 | Viewed by 41 | Submission Open
Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Combination Therapy for Lymphoma submission deadline 30 Sep 2026 | Viewed by 39 | Submission Open
Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs
(This special issue belongs to the Section Cancer Therapy)
Senescence and Cell Plasticity in Cancer Development
edited by and Elena Aguado-Domínguez
submission deadline 30 Sep 2026 | Viewed by 39 | Submission Open
Keywords: cellular senescence; cell plasticity; stem cells; SASP; therapy resistance; tumor microenvironment; cancer development
(This special issue belongs to the Section Molecular Cancer Biology)
Redefining Precision Radiotherapy
edited by Srinivasan Vijayakumar
submission deadline 30 Sep 2026 | Viewed by 34 | Submission Open
Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics
(This special issue belongs to the Section Methods and Technologies Development)
Psychological Factors and Cancer Survivorship
edited by and Ashley P. Ghiaseddin
submission deadline 30 Sep 2026 | Viewed by 29 | Submission Open
Keywords: psycho-oncology; distress; distress management; biobehavior markers and mechanisms; quality of life outcomes; treatment outcomes; survival outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy
edited by
submission deadline 30 Sep 2026 | Viewed by 25 | Submission Open
Keywords: nanomedicine; tumor-targeting mechanisms; cancers
(This special issue belongs to the Section Tumor Microenvironment)
Cancer Drug Resistance: Mechanisms and Overcoming Strategies
edited by
submission deadline 30 Sep 2026 | Viewed by 25 | Submission Open
Keywords: intrinsic resistance; acquired resistance; targeted therapy resistance; combination treatment strategies; immunotherapy resistance; tumor heterogeneity
(This special issue belongs to the Section Clinical Research of Cancer)
Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions
edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo
submission deadline 30 Sep 2026 | Viewed by 18 | Submission Open
Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery
(This special issue belongs to the Section Pediatric Oncology)
CRLM in the Era of Transplant Oncology: New Hope, New Questions
edited by Brian Davidson and
submission deadline 30 Sep 2026 | Viewed by 14 | Submission Open
Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance
(This special issue belongs to the Section Cancer Therapy)
Integrated Palliative Care in Advanced Cancer submission deadline 30 Sep 2026 | Viewed by 11 | Submission Open
Keywords: integrated palliative care; advanced cancer; cancer pain; symptom management; early integration; supportive care; end-of-Life care; patient-centered outcomes; tele-palliative care; refractory symptoms
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Extracellular Matrix Proteins in Cancer (2nd Edition)
edited by and Aikaterini Berdiaki
submission deadline 30 Sep 2026 | Viewed by 7 | Submission Open
Keywords: extracellular matrix (ECM); tumor microenvironment (TME); stromal remodeling; cancer-associated fibroblasts (CAFs); fibrous proteins; mechanotransduction; interstitial fluid pressure; proteoglycans and glycoproteins; matrix crosslinking; epithelial-to-mesenchymal transition (EMT); angiogenesis; matrikines; therapy resistance
(This special issue belongs to the Section Tumor Microenvironment)
Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 6 | Submission Open
Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis
(This special issue belongs to the Section Cancer Therapy)
Advances in Clinical Pharmacology in Lung Cancer—2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 4 | Submission Open
Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS
(This special issue belongs to the Section Cancer Drug Development)
Recent Advances in Myeloma: From Molecular Pathways to Drugs
edited by Natalia Neparidze
submission deadline 30 Sep 2026 | Submission Open
Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD
(This special issue belongs to the Section Cancer Drug Development)
Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition
edited by and Giorgio Mantovani
submission deadline 15 Oct 2026 | Viewed by 19 | Submission Open
Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care
edited by Roberto Berretta
submission deadline 20 Oct 2026 | Viewed by 34 | Submission Open
Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping
(This special issue belongs to the Section Cancer Therapy)
Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition submission deadline 30 Oct 2026 | Viewed by 51 | Submission Open
Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations submission deadline 31 Oct 2026 | Viewed by 129 | Submission Open
Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology
(This special issue belongs to the Section Cancer Pathophysiology)
Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 110 | Submission Open
Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research
(This special issue belongs to the Section Cancer Informatics and Big Data)
Molecular Targets and Therapeutic Pathways in Cancer
edited by Ashish H. Shah and Deepa Seetharam
submission deadline 31 Oct 2026 | Viewed by 98 | Submission Open
Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research
(This special issue belongs to the Section Cancer Drug Development)
Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers
edited by and Luís Ortega-Medina
submission deadline 31 Oct 2026 | Viewed by 63 | Submission Open
Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy submission deadline 31 Oct 2026 | Viewed by 46 | Submission Open
Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Overcoming Drug Resistance: Precision Medicine Drug Therapy
edited by , Yuting Huang and Raveena Manem
submission deadline 31 Oct 2026 | Viewed by 38 | Submission Open
Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system
(This special issue belongs to the Section Cancer Drug Development)
The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 37 | Submission Open
Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies
(This special issue belongs to the Section Tumor Microenvironment)
Molecular Imaging in Oncology: Recent Advances (2nd Edition) submission deadline 31 Oct 2026 | Viewed by 27 | Submission Open
Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry
(This special issue belongs to the Section Cancer Therapy)
New Findings in Targeting Cancer Proteins (Second Edition) submission deadline 30 Nov 2026 | 1 articles | Viewed by 744 | Submission Open
Keywords: monoclonal antibodies; protein target; immunotherapy; signaling blockade; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
New Approaches to Surgical Treatment and Care for Urological Cancer
edited by and Bente Thoft Jensen
submission deadline 30 Nov 2026 | Viewed by 61 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health
(This special issue belongs to the Section Clinical Research of Cancer)
Artificial Intelligence and Machine Learning in Lung Cancer Screening: Current Applications and Future Directions submission deadline 30 Nov 2026 | Viewed by 55 | Submission Open
Keywords: artificial intelligence; machine learning; lung cancer screening; low-dose CT; early detection
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Evolving Landscape of Squamous Cell Carcinoma of the Anal Canal: State of the Art, Current Challenges and Future Perspectives
edited by and Francesco Vasuri
submission deadline 15 Dec 2026 | Viewed by 20 | Submission Open
Keywords: squamous cell anal carcinoma; anal cancer; HIV; HPV
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Hematological Malignancies: From Translational Discoveries to Clinical Trends
edited by and Charyguly Annageldiyev
submission deadline 20 Dec 2026 | Viewed by 23 | Submission Open
Keywords: hematological malignancies; leukemia; lymphoma; myeloma; translational research; preclinical studies; clinical outcomes; molecular biomarkers; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy with Checkpoint Inhibitors for Non-Small-Cell Lung Cancer (2nd Edition) submission deadline 30 Dec 2026 | Viewed by 110 | Submission Open
Keywords: immune-checkpoint inhibitors; non-small cell lung cancer; neoadjuvant therapy; adjuvant therapy; primary resistance; acquired; resistance; biomarkers; immune-related adverse events
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
CancersScape: Spatial Biology of the Tumor Ecosystem
edited by and Sammy Ferri-Borgogno
submission deadline 31 Dec 2026 | Viewed by 428 | Submission Open
Keywords: cancer; health; tumor microenvironment; spatial biology; cancer diagnosis; cancer drug discovery; Omics
Cancer Patient Cognitive Disorders: Causes, Prevention and Management submission deadline 31 Dec 2026 | Viewed by 355 | Submission Open
Keywords: delirium; brain health; cognitive impairment; cancer; etiology; risk stratification; screening tool; biomarkers; postoperative delirium; pain management; delirium prevention; management; outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Tumor Microenvironment: Cellular Dynamics, Molecular Players, and Mechanisms of Therapy Resistance
edited by , Angeliki Ditsiou and
submission deadline 31 Dec 2026 | Viewed by 107 | Submission Open
Keywords: tumor microenvironment (TME); cellular interactions; molecular mechanisms; resistance mechanisms; signaling pathways; translational cancer therapy
(This special issue belongs to the Section Tumor Microenvironment)
Cancer Cell Communications, Metastasis and Survival in the Host Microenvironment—2nd Edition
edited by and
submission deadline 31 Dec 2026 | Viewed by 96 | Submission Open
Keywords: cancer cells; cancer cell-derived cytokines; host microenvironment; metastasis; gene alteration; signaling pathways; host cells
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Cancer Survival Analysis
edited by , Jianguang Ji and
submission deadline 31 Dec 2026 | Viewed by 67 | Submission Open
Keywords: cancer burden; cancer survival; epidemiology; survival analysis methodology; cancer screening; cancer control; cancer prognosis; cancer data mining
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Cutaneous Lymphomas: Present and Future
edited by
submission deadline 31 Dec 2026 | Viewed by 41 | Submission Open
Keywords: cutaneous lymphoma; T-cell lymphoma; B-cell lymphoma; mycosis fungoides; Sé zary syndrome; tumor microenvironment
Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life: 2nd Edition
edited by Shingen Nakamura
submission deadline 31 Dec 2026 | Viewed by 7 | Submission Open
Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Resistance in Lung Cancer
edited by Mohamed Gadelkarim
submission deadline 15 Mar 2027 | Viewed by 47 | Submission Open
Keywords: lung cancer; SCLC; NSCLC; drug resistance; genetic mutations; tumor microenvironment; EMT; biomarkers; targeted therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
New Statistical and Machine Learning Methods for Cancer Research
edited by Anjishnu Banerjee
submission deadline 20 May 2027 | Viewed by 78 | Submission Open
Keywords: statistical methods; machine learning; “Omics” research; adaptive clinical trials; drug development; personalized cancer therapies
(This special issue belongs to the Section Cancer Informatics and Big Data)
Cancer Causes and Control submission deadline 1 Dec 2027 | 4 articles | Viewed by 11289 | Submission Open
Keywords: cancer burden; risk factors for cancer; primary cancer prevention; secondary cancer prevention; tertiary cancer prevention; quality of life for people who have cancer; population-based cancer registry
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
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