Nanomedicine’s Role in Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 492

Special Issue Editors


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Guest Editor
2nd Department of Radiology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: nanomedicine; X-ray imaging; radiation dosimetry; diagnostic radiology; radiotherapy; hyperthermia

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Guest Editor
1. Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15780 Zografou, Greece
2. 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece
3. Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: biophotonics; laser ablation; optical tweezers; nanoparticles; ionizing radiation; atomic force microscopy
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Special Issue Information

Dear Colleagues,

Nanotechnology is a rapidly emerging field with diverse applications across a broad spectrum of sciences and engineering. The term nanomedicine refers to the use of nanotechnology in medicine, encompassing diagnostic, therapeutic, and theranostic approaches to various conditions. In oncology, the application of nanomedicine has seen dynamic growth over the past decade, leading to numerous cutting-edge advancements. The unique chemical, biological, and physical properties of nanoparticles, along with their functionalization, have contributed to significant breakthroughs. These include the development of novel nanocarriers for delivering chemotherapeutic agents, the use of nanoparticles as CT/MRI contrast agents, hyperthermia mediators, and their role as radiosensitizers in radiotherapy. This progress continues, and many more innovations are expected in the future.

This Special Issue of Cancers, titled “Nanomedicine’s Role in Oncology”, welcomes original research articles, as well as narrative and systematic reviews, on nanomedicine-related methods and developments in technology for the diagnosis and treatment of all cancer types. We invite colleagues to submit their work on topics such as nanotheranostics, nano-biomarkers, nano-biosensors, nanoparticle-mediated imaging modalities, nanoparticles as photosensitizers, radiosensitizers, and other general nanotools.

Prof. Dr. Efstathios Efstathopoulos
Dr. Ellas Spyratou
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • nanomedicine
  • oncology
  • interventional oncology
  • nanotechnology development
  • cancer diagnosis
  • cancer treatment
  • cancer imaging

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Published Papers (1 paper)

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Review

33 pages, 2309 KiB  
Review
Recent Progress of Nanomedicine for the Synergetic Treatment of Radiotherapy (RT) and Photothermal Treatment (PTT)
by Maria-Eleni Zachou, Ellas Spyratou, Nefeli Lagopati, Kalliopi Platoni and Efstathios P. Efstathopoulos
Cancers 2025, 17(14), 2295; https://doi.org/10.3390/cancers17142295 - 10 Jul 2025
Viewed by 267
Abstract
Nanotechnology has significantly advanced cancer therapy, particularly through the development of multifunctional nanoparticles (NPs) capable of acting as both therapeutic and diagnostic agents. This review focuses on the synergistic integration of radiotherapy (RT) and photothermal therapy (PTT) mediated by engineered NPs—a rapidly evolving [...] Read more.
Nanotechnology has significantly advanced cancer therapy, particularly through the development of multifunctional nanoparticles (NPs) capable of acting as both therapeutic and diagnostic agents. This review focuses on the synergistic integration of radiotherapy (RT) and photothermal therapy (PTT) mediated by engineered NPs—a rapidly evolving strategy that enhances tumor specificity, minimizes healthy tissue damage, and enables real-time imaging. By analyzing the recent literature, we highlight the dual role of NPs in amplifying radiation-induced DNA damage and converting near-infrared (NIR) light into localized thermal energy. The review classifies various metal-based and composite nanomaterials (e.g., Au, Pt, Bi, Cu, and Fe) and evaluates their performance in preclinical RT–PTT settings. We also discuss the physicochemical properties, targeting strategies, and theragnostic applications that contribute to treatment efficiency. Unlike conventional combinatorial therapies, NP-mediated RT–PTT enables high spatial–temporal control, immunogenic potential, and integration with multimodal imaging. We conclude with the current challenges, translational barriers, and outlooks for clinical implementation. This work provides a comprehensive, up-to-date synthesis of NP-assisted RT–PTT as a powerful approach within the emerging field of nano-oncology. Full article
(This article belongs to the Special Issue Nanomedicine’s Role in Oncology)
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