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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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CT/MRI/PET in Cancer submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open
Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open
Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up
(This special issue belongs to the Section Cancer Therapy)
Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
PARP Inhibitors in Cancers: 2nd Edition submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open
Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open
Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 5 | Submission Open
Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy
(This special issue belongs to the Section Cancer Metastasis)
Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open
Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance
(This special issue belongs to the Section Cancer Therapy)
Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life
edited by , and Juan Carlos Hernández-Rodríguez
submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open
Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 May 2026 | 3 articles | Viewed by 5171 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Cell Adhesion in Human Cancer
edited by , Makoto Osanai and
submission deadline 1 May 2026 | 2 articles | Viewed by 2901 | Submission Open
Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells
(This special issue belongs to the Section Molecular Cancer Biology)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 May 2026 | Viewed by 30 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Rehabilitation Opportunities in Cancer Survivorship
edited by and Alejandro Heredia-Ciuro
submission deadline 8 May 2026 | 1 articles | Viewed by 1840 | Submission Open
Keywords: cancer; rehabilitation; sequelae; disability; impairment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Hepatocellular Carcinoma Progression and Metastasis
edited by
submission deadline 10 May 2026 | Viewed by 37 | Submission Open
Keywords: hepatocellular carcinoma; tumor progression; metastasis; liver cancer; angiogenesis; epithelial– mesenchymal transition; tumor microenvironment; molecular pathways; biomarkers; targeted therapy; systemic therapy
(This special issue belongs to the Section Cancer Metastasis)
Infectious Agents and Cancer in Children and Adolescents
edited by and Eleni Tsotridou
submission deadline 15 May 2026 | 2 articles | Viewed by 2292 | Submission Open
Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses
(This special issue belongs to the Section Infectious Agents and Cancer)
Endoscopic Advances in Gastrointestinal Oncology
edited by Eduardo Rodrigues-Pinto
submission deadline 15 May 2026 | 1 articles | Viewed by 2043 | Submission Open
Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging
(This special issue belongs to the Section Cancer Therapy)
Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 66 | Submission Open
Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET
(This special issue belongs to the Section Molecular Cancer Biology)
Gene Editing and Delivery for Cancer Therapy (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 58 | Submission Open
Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science
(This special issue belongs to the Section Cancer Therapy)
Mass Spectrometry and Cancers submission deadline 15 May 2026 | Viewed by 18 | Submission Open
Keywords: cancer; biomolecular; mass spectrometry
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Surgical Management of Colorectal Cancer
edited by Gyung-mo Son
submission deadline 20 May 2026 | 8 articles | Viewed by 15455 | Submission Open
Keywords: colorectal cancer; surgical management; minimally invasive surgery; laparoscopic surgery; robotic surgery; single port surgery; emergency surgery; image-guided surgery; enhanced recovery after surgery (ERAS); systemic metastasis in colorectal cancer (involving the liver; lung; peritoneum; etc.)
(This special issue belongs to the Section Cancer Therapy)
Viral Oncogenes and Their Role in Cancer Pathogenesis
edited by and Yosef Sabo
submission deadline 21 May 2026 | 2 articles | Viewed by 3958 | Submission Open
Keywords: viral oncogenes; cancer pathogenesis; cellular regulation; tumorigenesis mechanisms; antiviral and anticancer strategies
(This special issue belongs to the Section Infectious Agents and Cancer)
Inhibitors in Thyroid Carcinoma (2nd Edition) submission deadline 24 May 2026 | Viewed by 61 | Submission Open
Keywords: thyroid carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; sorafenib; lenvatinib
(This special issue belongs to the Section Tumor Microenvironment)
Colorectal Cancer: Risk Factors and Underlying Mechanisms
edited by David Achaintre
submission deadline 25 May 2026 | Viewed by 21 | Submission Open
Keywords: colorectal cancer; diet; environmental factors; microbiome; inflammation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Current Advances in Management of Neuroendocrine Neoplasms
edited by Ashley Kieran Clift and
submission deadline 30 May 2026 | 1 articles | Viewed by 408 | Submission Open
Keywords: neuroendocrine tumours; epidemiology; clinical prediction models; machine learning; personalised medicine; novel biomarkers; diagnostics; treatment; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Genetics of Ovarian Cancer (2nd Edition) submission deadline 30 May 2026 | Viewed by 55 | Submission Open
Keywords: epithelial ovarian cancer; genomics; epigenetics; translational research; biomarkers; DNA damage response; PARP inhibitors
(This special issue belongs to the Section Cancer Pathophysiology)
Updates on Depression Among Cancer Patients (2nd Edition)
edited by Wen-Yu Hu, and
submission deadline 30 May 2026 | Viewed by 39 | Submission Open
Keywords: depression; psychotherapy; oncology nursing
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Prostate Cancer and Inflammation
edited by Takuji Hayashi
submission deadline 31 May 2026 | 1 articles | Viewed by 1429 | Submission Open
Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advance in Treatment of Uveal Melanoma submission deadline 31 May 2026 | 1 articles | Viewed by 1187 | Submission Open
Keywords: uveal melanoma; distant metastases; treatment modalities
(This special issue belongs to the Section Cancer Therapy)
Focus on Focal Therapy for Prostate Cancer
edited by Abhinav Sidana and Samuel Tremblay
submission deadline 31 May 2026 | 1 articles | Viewed by 964 | Submission Open
Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance
(This special issue belongs to the Section Cancer Therapy)
Developments in the Management of Gastrointestinal Malignancies (2nd Edition)
edited by Zachary J. Brown
submission deadline 31 May 2026 | 1 articles | Viewed by 462 | Submission Open
Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic
(This special issue belongs to the Section Cancer Therapy)
Therapeutic Optimization of Anti-Tumor Drugs Based on Pharmacokinetics
edited by Paula Fresco and Joaquim António Faria Monteiro
submission deadline 31 May 2026 | Viewed by 227 | Submission Open
Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models
(This special issue belongs to the Section Cancer Drug Development)
The Role of Circulating Tumor Cells in Colorectal Cancer
edited by
submission deadline 31 May 2026 | Viewed by 211 | Submission Open
Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation
(This special issue belongs to the Section Cancer Biomarkers)
Gut Microbiome, Diet and Cancer Risk
edited by
submission deadline 31 May 2026 | Viewed by 73 | Submission Open
Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Clinical and Translational Research of Urological Cancer submission deadline 31 May 2026 | Viewed by 59 | Submission Open
Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence
(This special issue belongs to the Section Clinical Research of Cancer)
The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine
edited by Aftab Alam
submission deadline 31 May 2026 | Viewed by 55 | Submission Open
Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Mutagenesis and DNA Methylation in Aging
edited by Steven S. Smith
submission deadline 31 May 2026 | Viewed by 52 | Submission Open
Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease
edited by
submission deadline 31 May 2026 | Viewed by 36 | Submission Open
Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy; quality of life; and prognosis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Clinical Imaging and Immunotherapy in Cancer Research
edited by
submission deadline 31 May 2026 | Viewed by 33 | Submission Open
Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics
(This special issue belongs to the Section Clinical Research of Cancer)
Role of Cytokines in Cancer (2nd Edition) submission deadline 31 May 2026 | Viewed by 31 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
Emerging Nanotechnology and Advanced Materials for Cancer Therapy
edited by
submission deadline 31 May 2026 | Viewed by 30 | Submission Open
Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology
(This special issue belongs to the Section Methods and Technologies Development)
Infectious Agents and Oesophageal Cancer (2nd Edition)
edited by and Mohammed Rabiei
submission deadline 31 May 2026 | Viewed by 28 | Submission Open
Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma
(This special issue belongs to the Section Infectious Agents and Cancer)
Targeted Therapy in Gastrointestinal Cancer (2nd Edition)
edited by and
submission deadline 31 May 2026 | Viewed by 25 | Submission Open
Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development
(This special issue belongs to the Section Cancer Therapy)
Multimodality Management of Sarcomas (2nd Edition)
edited by
submission deadline 31 May 2026 | Viewed by 24 | Submission Open
Keywords: sarcomas; multimodal; pathology; radiology; surgery; chemotherapy; radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers
edited by , Matteo Serenari and
submission deadline 31 May 2026 | Viewed by 24 | Submission Open
Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy
(This special issue belongs to the Section Cancer Therapy)
Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma
edited by
submission deadline 31 May 2026 | Viewed by 18 | Submission Open
Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Neoadjuvant Chemotherapy and Radiotherapy for Breast Cancer: Surgical Impact and Clinical Outcomes
edited by Amparo García-Tejedor
submission deadline 31 May 2026 | Viewed by 10 | Submission Open
Keywords: neoadjuvant chemotherapy; radiotherapy; breast cancer; surgical outcomes; tumor downstaging; personalized therapy; breast-conserving surgery; mastectomy; clinical outcomes
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy for the Management of Brain Metastases
edited by Alla Gabriella Wernicke
submission deadline 31 May 2026 | Viewed by 2 | Submission Open
Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research
(This special issue belongs to the Section Cancer Metastasis)
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