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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Future of Machine Learning in Predicting Cancer Treatment Response

edited by

Gholamreza Rafiee

submission deadline 25 Oct 2026 | Viewed by 15 | Submission Open

Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response

(This special issue belongs to the Section Methods and Technologies Development)

Gynecological Cancers: From Bench to Bedside

edited by

Francesco Cosentino

submission deadline 30 Oct 2026 | Viewed by 99 | Submission Open

Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition

edited by

Vito Andrea Capozzi

submission deadline 30 Oct 2026 | Viewed by 98 | Submission Open

Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Sphingolipids in Cancer Progression

edited by

Jeremy Hengst

submission deadline 30 Oct 2026 | Viewed by 98 | Submission Open

Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development

(This special issue belongs to the Section Molecular Cancer Biology)

The Current Status of Brain Tumor Imaging: 2nd Edition

edited by

Houman Sotoudeh

submission deadline 30 Oct 2026 | Viewed by 94 | Submission Open

Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI

(This special issue belongs to the Section Cancer Therapy)

Cancer Prevention and Screening: Innovations, Implementation, and Access

edited by

Jaclyn M. Hall

and Rahma S. Mkuu

submission deadline 30 Oct 2026 | Viewed by 82 | Submission Open

Keywords: cancer; prevention; screening; intervention; implementation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Gastrointestinal Tumors: Screening and Prevention

edited by

Hans Scherübl

submission deadline 30 Oct 2026 | Viewed by 62 | Submission Open

Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy

Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment

edited by Shahidul M. Islam

submission deadline 30 Oct 2026 | Viewed by 59 | Submission Open

Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling

(This special issue belongs to the Section Tumor Microenvironment)

Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications

edited by

Appu Rathinavelu

and Umamaheswari Natarajan

submission deadline 30 Oct 2026 | Viewed by 50 | Submission Open

Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1; DNMT3A; DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA

(This special issue belongs to the Section Molecular Cancer Biology)

Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers

edited by

Linhui Wang

and

Aimin Jiang

submission deadline 30 Oct 2026 | Viewed by 48 | Submission Open

Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Clinical Research of Brachytherapy in Cancer

edited by Ludmiła Grzybowska-Szatkowska,

Paweł Cisek

and Aleksandra Kozłowska

submission deadline 30 Oct 2026 | Viewed by 46 | Submission Open

Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm

(This special issue belongs to the Section Clinical Research of Cancer)

Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives

edited by

Masahiko Kinoshita

submission deadline 30 Oct 2026 | Viewed by 39 | Submission Open

Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2026 | 8 articles | Viewed by 16246 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations

edited by

Paola Parente

and

Marco Donatello Delcuratolo

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1424 | Submission Open

Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology

(This special issue belongs to the Section Cancer Pathophysiology)

The Role of Nutrients in Cancer Progression

edited by

Ikuko Kato

submission deadline 31 Oct 2026 | Viewed by 325 | Submission Open

Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Pathophysiology)

Artificial Intelligence-Driven Multi-Omics Integration for Precision Oncology and Complex Disease Research

edited by

Hengrui Liu

and

Qi Wang

submission deadline 31 Oct 2026 | Viewed by 182 | Submission Open

Keywords: artificial intelligence; multi-omics; precision medicine; biomarker; deep learning

(This special issue belongs to the Section Cancer Informatics and Big Data)

Overcoming Drug Resistance: Precision Medicine Drug Therapy

edited by

Chenyu Sun

, Yuting Huang and Raveena Manem

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system

(This special issue belongs to the Section Cancer Drug Development)

Molecular Targets and Therapeutic Pathways in Cancer

edited by Ashish H. Shah and Deepa Seetharam

submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open

Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research

(This special issue belongs to the Section Cancer Drug Development)

Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications

edited by

Luciano Cascione

submission deadline 31 Oct 2026 | Viewed by 148 | Submission Open

Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research

(This special issue belongs to the Section Cancer Informatics and Big Data)

Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers

edited by

Cristina Díaz del Arco

and Luís Ortega-Medina

submission deadline 31 Oct 2026 | Viewed by 124 | Submission Open

Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Current Research in Pediatric Hematological Oncology

edited by

Santhosh Kumar Pasupuleti

and

Tzu-Chieh Ho

submission deadline 31 Oct 2026 | Viewed by 119 | Submission Open

Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models

(This special issue belongs to the Section Pediatric Oncology)

Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management

edited by

S. D. Brookman-May

submission deadline 31 Oct 2026 | Viewed by 106 | Submission Open

Keywords: artificial intelligence; machine learning; urological oncology; imaging; precision medicine; digital pathology; therapeutic decision-making

(This special issue belongs to the Section Cancer Therapy)

Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy

edited by

Maria Maddalena Marrapodi

submission deadline 31 Oct 2026 | Viewed by 97 | Submission Open

Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Synergistic Radiotherapy and Immunotherapy in Cancer Treatment

edited by

Xiaju Cheng

submission deadline 31 Oct 2026 | Viewed by 92 | Submission Open

Keywords: radiotherapy; immunotherapy; combination therapy; nanomedicine; immunogenic cell death; tumor microenvironment; immune checkpoint inhibitors; abscopal effect; systemic immunity; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Signaling Networks and Systems Biology in Cancer

edited by

Rajesh Singh

and

Abhinava K. Mishra

submission deadline 31 Oct 2026 | Viewed by 88 | Submission Open

Keywords: cancer signaling; immuno-oncology; cancer nanotechnology; AI/ML in cancer; systems oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation

edited by Eleanor J. Cheadle and

Jamie Honeychurch

submission deadline 31 Oct 2026 | Viewed by 76 | Submission Open

Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death

Molecular Imaging in Oncology: Recent Advances (2nd Edition)

edited by

Lioe-Fee de Geus-Oei

submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry

(This special issue belongs to the Section Cancer Therapy)

The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition

edited by

Roberto Tamma

submission deadline 31 Oct 2026 | Viewed by 72 | Submission Open

Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies

(This special issue belongs to the Section Tumor Microenvironment)

Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis

edited by

Athina N. Markou

submission deadline 31 Oct 2026 | Viewed by 72 | Submission Open

Keywords: CTCs; liquid biopsy; metastasis; biomarkers

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Lifestyle Choices in Cancer Risk

edited by Itunu O. Sokale, Aaron P. Thrift and

Xiaotao Zhang

submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open

Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention

Metabolism and Precision Oncology

edited by Rays H.Y. Jiang and Gloria C. Ferreira

submission deadline 31 Oct 2026 | Viewed by 64 | Submission Open

Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting

(This special issue belongs to the Section Cancer Pathophysiology)

Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition)

edited by

Francesco E. Boccalatte

submission deadline 31 Oct 2026 | Viewed by 61 | Submission Open

Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation

(This special issue belongs to the Section Cancer Therapy)

Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities

edited by

Michele Zanoni

, Giacomo Miserocchi and

Tania Rossi

submission deadline 31 Oct 2026 | Viewed by 61 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; tumor– stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models

(This special issue belongs to the Section Tumor Microenvironment)

AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive, and Adaptive Cancer Treatment

edited by Zhen Tian and Chaoqiong Ma

submission deadline 31 Oct 2026 | Viewed by 58 | Submission Open

Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Opportunities and Challenges in Cancer Immunotherapies

edited by

Gao Zhang

submission deadline 31 Oct 2026 | Viewed by 56 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies

edited by

Francesco Marotta

and

Reza Rastmanesh

submission deadline 31 Oct 2026 | Viewed by 54 | Submission Open

Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery

(This special issue belongs to the Section Cancer Therapy)

Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition

edited by

Kazunori Kageyama

and

Mitsuru Nishiyama

submission deadline 31 Oct 2026 | Viewed by 49 | Submission Open

Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment

Innovations in Surgical and Management Strategies for Complex and Advanced Gastric Cancer

edited by

Tsutomu Namikawa

and

Kazuhiro Hanazaki

submission deadline 31 Oct 2026 | Viewed by 43 | Submission Open

Keywords: advanced gastric cancer; surgical innovation; multimodal therapy; minimally invasive gastrectomy (robotic/laparoscopic); perioperative management; immunotherapy; precision medicine; peritoneal metastasis

(This special issue belongs to the Section Clinical Research of Cancer)

Local, Systemic and Combined Therapy for Hepatocellular Carcinoma

edited by Xiaoqun Dong

submission deadline 31 Oct 2026 | Viewed by 41 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research

(This special issue belongs to the Section Cancer Therapy)

Advances in Imaging Techniques of Molecular Oncology (2nd Edition)

edited by

Angela Spanu

submission deadline 31 Oct 2026 | Viewed by 39 | Submission Open

Keywords: cancer; oncological imaging; molecular imaging; SPECT/TC; PET/CT; PET/MRI; DWI; DCE-MRI; nanotheranostics; artificial intelligence; radiomics; theranostics

(This special issue belongs to the Section Methods and Technologies Development)

Skin and Hair Side Effects of Cancer Treatment

edited by Ian W. Tattersall

submission deadline 31 Oct 2026 | Viewed by 29 | Submission Open

Keywords: oncodermatology; toxicity management; supportive oncology

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Glioma Immunotherapy

edited by Tomasz Tykocki

submission deadline 5 Nov 2026 | Viewed by 10 | Submission Open

Keywords: glioma immunotherapy; tumor microenvironment; immune evasion; microglia; checkpoint inhibitors; CAR‑T; neoantigen vaccines

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer

edited by

Héctor Guadalajara

and Miguel Leon-Arellano

submission deadline 15 Nov 2026 | Viewed by 113 | Submission Open

Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors

edited by Ciprian Brisc and Nadim Al Hajjar

submission deadline 15 Nov 2026 | Viewed by 34 | Submission Open

Keywords: gastrointestinal; hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization

(This special issue belongs to the Section Cancer Therapy)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition

edited by

Salvatore Tafuto

Ottavia Clemente

and

Annabella Di Mauro

submission deadline 20 Nov 2026 | Viewed by 42 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

Infectious Pathogens and Cancer

edited by

W. Martin Kast

submission deadline 25 Nov 2026 | Viewed by 22 | Submission Open

Keywords: infectious cancer pathogens; related topics in immunology; virology; epidemiology; (therapeutic) vaccines; oncogenesis; screening; therapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Cancer Cells Fostered Microenvironment in Metastasis (2nd Edition)

edited by

Lin Ye

submission deadline 25 Nov 2026 | Viewed by 17 | Submission Open

Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy

(This special issue belongs to the Section Cancer Metastasis)

Treatment and Prognosis of Pediatric Medulloblastoma

edited by Marwa Ismail

submission deadline 25 Nov 2026 | Viewed by 16 | Submission Open

Keywords: pediatric medulloblastoma; proteomics; radiogenomics

(This special issue belongs to the Section Pediatric Oncology)

Radiologic Staging and Surgical Decision-Making in the Era of Neoadjuvant Therapy for Breast Cancer

edited by

Damiano Gentile

submission deadline 25 Nov 2026 | Viewed by 15 | Submission Open

Keywords: radiologic staging; neoadjuvant therapy; breast cancer; breast-conserving surgery; mastectomy; targeted axillary dissection; sentinel lymph node biopsy; axillary lymph node dissection; magnetic resonance imaging; surgical de-escalation

(This special issue belongs to the Section Cancer Therapy)

New Findings in Targeting Cancer Proteins (Second Edition)

edited by

Maristella Maggi

and