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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Cellular Ecosystem of Cancer: New Insights into Cell Biology

edited by Xiaochao Tan and

Guan-Yu Xiao

submission deadline 30 Sep 2026 | Viewed by 47 | Submission Open

Keywords: cell organelle; ER; mitochondria; lysosome; Golgi; secretion; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Myeloma: From Molecular Pathways to Drug Development

edited by Natalia Neparidze

submission deadline 30 Sep 2026 | Viewed by 40 | Submission Open

Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD

(This special issue belongs to the Section Cancer Drug Development)

Health-Related Quality of Life in Cancer Survivorship

edited by Deniz Gencer and Elisabeth Coyne

submission deadline 30 Sep 2026 | Viewed by 39 | Submission Open

Keywords: cancer survivorship; health-related quality of life (HRQoL); interventions; psychological support; personalized care; educational resources

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Leukemia Stem Cells: Persistence, Resistance, and Novel Eradication Strategies

edited by Elisa Donato and Darja Karpova

submission deadline 30 Sep 2026 | Viewed by 37 | Submission Open

Keywords: leukemia stem cells (LSCs); acute myeloid leukemia (AML); therapeutic resistance; minimal residual disease (MRD); LSC quiescence; cellular therapy; hematopoietic stem cell transplantation (HSCT); LSC microenvironment

Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advances in Clinical Care and Therapeutics

edited by

Benjamin D. Powers

submission deadline 30 Sep 2026 | Viewed by 34 | Submission Open

Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases

(This special issue belongs to the Section Cancer Therapy)

Pancreatic Cancer Ultrasound: A Problem-Based Approach

edited by

Carla Serra

and Andrea Boccatonda

submission deadline 30 Sep 2026 | Viewed by 27 | Submission Open

Keywords: cancer; ultrasound; pancreas; CEUS; malignancy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Trials and Translational Research in Multiple Myeloma

edited by Laszlo Varoczy

submission deadline 30 Sep 2026 | Viewed by 26 | Submission Open

Keywords: multiple myeloma; disease evolution; translational research; personalizing therapy; clinical trial

(This special issue belongs to the Section Clinical Research of Cancer)

Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Oreste Gallo

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1047 | Submission Open

Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx

(This special issue belongs to the Section Cancer Therapy)

Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition

edited by

Alba Scerrati

and Giorgio Mantovani

submission deadline 15 Oct 2026 | 1 articles | Viewed by 530 | Submission Open

Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum

edited by Jennifer Michelle Jones

submission deadline 15 Oct 2026 | Viewed by 62 | Submission Open

Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care

edited by Roberto Berretta

submission deadline 20 Oct 2026 | Viewed by 89 | Submission Open

Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping

(This special issue belongs to the Section Cancer Therapy)

The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration

edited by Thomas J. Fitzgerald

submission deadline 20 Oct 2026 | Viewed by 34 | Submission Open

Keywords: radiation; proton; photon; brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2026 | 4 articles | Viewed by 12150 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

The Future of Machine Learning in Predicting Cancer Treatment Response

edited by

Gholamreza Rafiee

submission deadline 25 Oct 2026 | Viewed by 25 | Submission Open

Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Sphingolipids in Cancer Progression

edited by

Jeremy Hengst

submission deadline 30 Oct 2026 | Viewed by 108 | Submission Open

Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development

(This special issue belongs to the Section Molecular Cancer Biology)

Gynecological Cancers: From Bench to Bedside

edited by

Francesco Cosentino

submission deadline 30 Oct 2026 | Viewed by 102 | Submission Open

Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Current Status of Brain Tumor Imaging: 2nd Edition

edited by

Houman Sotoudeh

submission deadline 30 Oct 2026 | Viewed by 100 | Submission Open

Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI

(This special issue belongs to the Section Cancer Therapy)

Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition

edited by

Vito Andrea Capozzi

submission deadline 30 Oct 2026 | Viewed by 98 | Submission Open

Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cancer Prevention and Screening: Innovations, Implementation, and Access

edited by

Jaclyn M. Hall

and Rahma S. Mkuu

submission deadline 30 Oct 2026 | Viewed by 87 | Submission Open

Keywords: cancer; prevention; screening; intervention; implementation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment

edited by Shahidul M. Islam

submission deadline 30 Oct 2026 | Viewed by 64 | Submission Open

Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling

(This special issue belongs to the Section Tumor Microenvironment)

Gastrointestinal Tumors: Screening and Prevention

edited by

Hans Scherübl

submission deadline 30 Oct 2026 | Viewed by 63 | Submission Open

Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy

Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications

edited by

Appu Rathinavelu

and Umamaheswari Natarajan

submission deadline 30 Oct 2026 | Viewed by 56 | Submission Open

Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1; DNMT3A; DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA

(This special issue belongs to the Section Molecular Cancer Biology)

Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers

edited by

Linhui Wang

and

Aimin Jiang

submission deadline 30 Oct 2026 | Viewed by 51 | Submission Open

Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Clinical Research of Brachytherapy in Cancer

edited by Ludmiła Grzybowska-Szatkowska,

Paweł Cisek

and Aleksandra Kozłowska

submission deadline 30 Oct 2026 | Viewed by 47 | Submission Open

Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm

(This special issue belongs to the Section Clinical Research of Cancer)

Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives

edited by

Masahiko Kinoshita

submission deadline 30 Oct 2026 | Viewed by 41 | Submission Open

Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2026 | 8 articles | Viewed by 17037 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations

edited by

Paola Parente

and

Marco Donatello Delcuratolo

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1775 | Submission Open

Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology

(This special issue belongs to the Section Cancer Pathophysiology)

The Role of Nutrients in Cancer Progression

edited by

Ikuko Kato

submission deadline 31 Oct 2026 | Viewed by 325 | Submission Open

Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Pathophysiology)

Artificial Intelligence-Driven Multi-Omics Integration for Precision Oncology and Complex Disease Research

edited by

Hengrui Liu

and

Qi Wang

submission deadline 31 Oct 2026 | Viewed by 195 | Submission Open

Keywords: artificial intelligence; multi-omics; precision medicine; biomarker; deep learning

(This special issue belongs to the Section Cancer Informatics and Big Data)

Overcoming Drug Resistance: Precision Medicine Drug Therapy

edited by

Chenyu Sun

, Yuting Huang and Raveena Manem

submission deadline 31 Oct 2026 | Viewed by 173 | Submission Open

Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system

(This special issue belongs to the Section Cancer Drug Development)

Molecular Targets and Therapeutic Pathways in Cancer

edited by Ashish H. Shah and Deepa Seetharam

submission deadline 31 Oct 2026 | Viewed by 162 | Submission Open

Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research

(This special issue belongs to the Section Cancer Drug Development)

Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications

edited by

Luciano Cascione

submission deadline 31 Oct 2026 | Viewed by 152 | Submission Open

Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research

(This special issue belongs to the Section Cancer Informatics and Big Data)

Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers

edited by

Cristina Díaz del Arco

and Luís Ortega-Medina

submission deadline 31 Oct 2026 | Viewed by 135 | Submission Open

Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Current Research in Pediatric Hematological Oncology

edited by

Santhosh Kumar Pasupuleti

and

Tzu-Chieh Ho

submission deadline 31 Oct 2026 | Viewed by 126 | Submission Open

Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models

(This special issue belongs to the Section Pediatric Oncology)

Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management

edited by

S. D. Brookman-May

submission deadline 31 Oct 2026 | Viewed by 110 | Submission Open

Keywords: artificial intelligence; machine learning; urological oncology; imaging; precision medicine; digital pathology; therapeutic decision-making

(This special issue belongs to the Section Cancer Therapy)

Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy

edited by

Maria Maddalena Marrapodi

submission deadline 31 Oct 2026 | Viewed by 104 | Submission Open

Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Synergistic Radiotherapy and Immunotherapy in Cancer Treatment

edited by

Xiaju Cheng

submission deadline 31 Oct 2026 | Viewed by 94 | Submission Open

Keywords: radiotherapy; immunotherapy; combination therapy; nanomedicine; immunogenic cell death; tumor microenvironment; immune checkpoint inhibitors; abscopal effect; systemic immunity; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Signaling Networks and Systems Biology in Cancer

edited by

Rajesh Singh

and

Abhinava K. Mishra

submission deadline 31 Oct 2026 | Viewed by 91 | Submission Open

Keywords: cancer signaling; immuno-oncology; cancer nanotechnology; AI/ML in cancer; systems oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities

edited by

Michele Zanoni

, Giacomo Miserocchi and

Tania Rossi

submission deadline 31 Oct 2026 | Viewed by 81 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; tumor– stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models

(This special issue belongs to the Section Tumor Microenvironment)

Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation

edited by Eleanor J. Cheadle and

Jamie Honeychurch

submission deadline 31 Oct 2026 | Viewed by 80 | Submission Open

Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death

The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition

edited by

Roberto Tamma

submission deadline 31 Oct 2026 | Viewed by 79 | Submission Open

Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies

(This special issue belongs to the Section Tumor Microenvironment)

Molecular Imaging in Oncology: Recent Advances (2nd Edition)

edited by

Lioe-Fee de Geus-Oei

submission deadline 31 Oct 2026 | Viewed by 75 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry

(This special issue belongs to the Section Cancer Therapy)

Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis

edited by

Athina N. Markou

submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open

Keywords: CTCs; liquid biopsy; metastasis; biomarkers

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Lifestyle Choices in Cancer Risk

edited by Itunu O. Sokale, Aaron P. Thrift and

Xiaotao Zhang

submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open

Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention

Metabolism and Precision Oncology

edited by Rays H.Y. Jiang and Gloria C. Ferreira

submission deadline 31 Oct 2026 | Viewed by 67 | Submission Open

Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting

(This special issue belongs to the Section Cancer Pathophysiology)

Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition)

edited by

Francesco E. Boccalatte

submission deadline 31 Oct 2026 | Viewed by 63 | Submission Open

Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation

(This special issue belongs to the Section Cancer Therapy)

Opportunities and Challenges in Cancer Immunotherapies

edited by

Gao Zhang

submission deadline 31 Oct 2026 | Viewed by 62 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive, and Adaptive Cancer Treatment

edited by Zhen Tian and Chaoqiong Ma

submission deadline 31 Oct 2026 | Viewed by 61 | Submission Open

Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies

edited by

Francesco Marotta

and

Reza Rastmanesh

submission deadline 31 Oct 2026 | Viewed by 55 | Submission Open

Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery

(This special issue belongs to the Section Cancer Therapy)

Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition

edited by

Kazunori Kageyama

and

Mitsuru Nishiyama

submission deadline 31 Oct 2026 | Viewed by 51 | Submission Open

Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment

Displaying special issue 1101-1150 on page 23 of 25.

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