Molecular Genetics, Signaling Pathways, and Therapeutic Strategies for Liver Cancer

Dear Colleagues,

Liver cancer is a leading fatal human cancer. It is known to have a high degree of heterogeneity, leading to frequent treatment resistance and disease recurrence. There are a limited number of treatment options and they are not adequately effective. The hepatocarcinogenesis process of liver cancer is complex and involves the endeavor of malignant and immune components. There is an accumulation of various genetic and epigenetic alterations that pinpoint key signaling pathways or biological processes. With the emergence of different sequencing-based strategies, high-throughput screening platforms as well as computational algorithms, we can delineate the underlying molecular and cellular landscapes in liver cancer to a better extent. This Special Collection will focus on various niche areas that cover the basic as well as translational aspects of liver cancer research.

This Special Issue will include the following topics:

- Tumor heterogeneity;

- Transcriptomic landscape;

- Genomic landscape;

- Epigenetic landscape;

- Cellular landscape;

- Single-cell analysis;

- Spatial transcriptomics;

- Tumor microenvironment;

- Liver cancer stem cell;

- Liquid biopsy;

- Biomarkers.

Dr. Wai-Hung Ho Daniel
Dr. Yuman Tsui
Guest Editors

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