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Systematic Review

The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review

1
UCL Centre for 3D models of Health and Disease, Division of Surgery and Interventional Sciences University College London, London WC1E 6BT, UK
2
Medical Biosciences, Faculty of Medicine, Imperial College London, London SW7 2BU, UK
*
Authors to whom correspondence should be addressed.
Academic Editors: Ciro Isidoro, Danny N. Dhanasekaran and Sudip K. Das
Cancers 2021, 13(6), 1334; https://doi.org/10.3390/cancers13061334
Received: 27 January 2021 / Revised: 5 March 2021 / Accepted: 13 March 2021 / Published: 16 March 2021
(This article belongs to the Special Issue Epigenetic and Metabolic Alterations in the Tumor Microenvironment)
Cancer remains one of the leading causes of death worldwide. The advancements in 3D tumour models provide in vitro test-beds to study cancer growth, metastasis and response to therapy. We conducted this systematic review on existing experimental studies in order to identify and summarize key biomimetic tumour microenvironmental features which affect aspects of cancer biology. The review noted the significance of in vitro hypoxia and 3D tumour models on epithelial to mesenchymal transition, drug resistance, invasion and migration of cancer cells. We highlight the importance of various experimental parameters used in these studies and their subsequent effects on cancer cell behaviour.
The development of biomimetic, human tissue models is recognized as being an important step for transitioning in vitro research findings to the native in vivo response. Oftentimes, 2D models lack the necessary complexity to truly recapitulate cellular responses. The introduction of physiological features into 3D models informs us of how each component feature alters specific cellular response. We conducted a systematic review of research papers where the focus was the introduction of key biomimetic features into in vitro models of cancer, including 3D culture and hypoxia. We analysed outcomes from these and compiled our findings into distinct groupings to ascertain which biomimetic parameters correlated with specific responses. We found a number of biomimetic features which primed cancer cells to respond in a manner which matched in vivo response. View Full-Text
Keywords: 3D; cancer models; hypoxia; cancer stem cells; drug resistance; epithelial-to-mesenchymal transition; invasion; migration 3D; cancer models; hypoxia; cancer stem cells; drug resistance; epithelial-to-mesenchymal transition; invasion; migration
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MDPI and ACS Style

Liu, Y.; Mohri, Z.; Alsheikh, W.; Cheema, U. The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review. Cancers 2021, 13, 1334. https://doi.org/10.3390/cancers13061334

AMA Style

Liu Y, Mohri Z, Alsheikh W, Cheema U. The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review. Cancers. 2021; 13(6):1334. https://doi.org/10.3390/cancers13061334

Chicago/Turabian Style

Liu, Ye, Zahra Mohri, Wissal Alsheikh, and Umber Cheema. 2021. "The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review" Cancers 13, no. 6: 1334. https://doi.org/10.3390/cancers13061334

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