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Cancers
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The Role of Genes in Prostate Cancer
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The Role of Genes in Prostate Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 4556

Special Issue Editor

Prof. Dr. Olivier Cussenot

E-Mail Website
Guest Editor
Nuffield Department of Surgical Sciences, University of Oxford, Level 6, Room 6600, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
Interests: prostate cancer; genetics; genomics; immunity; microenvironment; DNA repair

Special Issue Information

Dear Colleagues,

We are delighted to introduce this Special Issue of Cancers on the role of genes in prostate cancer. Prostate cancer is the fifth leading cause of cancer death in men worldwide, with an estimated 1.4 million cases of prostate cancer diagnosed, and an estimated 375,000 men have died from prostate cancer. Prostate cancer is a clinical and molecular heterogeneous disease with disparities in incidence and mortality. This Special Issue will highlight new genetic and genomic insights into prostate cancers, which have provided a better comprehensive landscape of the germline variations or somatic molecular profiles involved in prostate cancer carcinogenesis or in the progression to metastatic and lethal disease.

Prof. Dr. Olivier Cussenot
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • genes
  • microenvironment

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Published Papers (3 papers)

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Research

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9 pages, 2021 KiB  
Article
Spatial Genomics Identifies Heat Shock Proteins as Key Molecular Changes Associated to Adipose Periprostatic Space Invasion in Prostate Cancer
by Olivier Cussenot, Lucie Poupel, Coralie Mousset, Julien Lavergne, Franck Bruyere, Alix Fontaine, Géraldine Cancel-Tassin and Gaelle Fromont-Hankard
Cancers 2025, 17(1), 2; https://doi.org/10.3390/cancers17010002 - 24 Dec 2024
Cited by 1 | Viewed by 901
Abstract
Purpose: To identify molecular changes during PCa invasion of adipose space using Spatial Transcriptomic Profiling of PCa cells. Methods: This study was performed on paired intraprostatic and extraprostatic samples obtained from radical prostatectomy with pT3a pathological stages. Results: Differential gene expression revealed upregulation [...] Read more.
Purpose: To identify molecular changes during PCa invasion of adipose space using Spatial Transcriptomic Profiling of PCa cells. Methods: This study was performed on paired intraprostatic and extraprostatic samples obtained from radical prostatectomy with pT3a pathological stages. Results: Differential gene expression revealed upregulation of heat shock protein genes: DNAJB1, HSPA8, HSP90AA1, HSPA1B, HSPA1A in PCa PanCK+ cells from the adipose periprostatic space. Extraprostatic extension was significantly associated with overexpression of genes involved in metastatic spread (EGR1, OR51E2, SPON2), of aggressiveness ERG negative signature of enhancers of androgen receptor (HOXB13, FOXA1), and of PSMA (FOLH1). They were associated with loss at 6q, 10q, 16q, and gain at 8q24 locus. Conclusions: PCa invasion of adipose EPE induces adaptative process related to heat shock proteins; PCa cells in EPE also present transcriptomics signatures for ERG independent aggressiveness, androgen receptor co-activation, and specific CNV changes. Full article
(This article belongs to the Special Issue The Role of Genes in Prostate Cancer)
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Review

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15 pages, 1360 KiB  
Review
TP53 Deficiency in the Natural History of Prostate Cancer
by Heidemarie Ofner, Gero Kramer, Shahrokh F. Shariat and Melanie R. Hassler
Cancers 2025, 17(4), 645; https://doi.org/10.3390/cancers17040645 - 14 Feb 2025
Viewed by 1078
Abstract
Prostate cancer remains a leading cause of cancer-related mortality in men, with advanced stages posing significant treatment challenges due to high morbidity and mortality. Among genetic alterations, TP53 mutations are among the most prevalent in cancers and are strongly associated with poor clinical [...] Read more.
Prostate cancer remains a leading cause of cancer-related mortality in men, with advanced stages posing significant treatment challenges due to high morbidity and mortality. Among genetic alterations, TP53 mutations are among the most prevalent in cancers and are strongly associated with poor clinical outcomes and therapeutic resistance. This review investigates the role of TP53 mutations in prostate cancer progression, prognosis, and therapeutic development. A comprehensive analysis of preclinical and clinical studies was conducted to elucidate the molecular mechanisms, clinical implications, and potential therapeutic approaches associated with TP53 alterations in prostate cancer. TP53 mutations are highly prevalent in advanced stages, contributing to genomic instability, aggressive tumor phenotypes, and resistance to standard treatments. Emerging evidence supports the utility of liquid biopsy techniques, such as circulating tumor DNA analysis, for detecting TP53 mutations, providing prognostic value and facilitating early intervention strategies. Novel therapeutic approaches targeting TP53 have shown promise in preclinical settings, but their clinical efficacy requires further validation. Overall, TP53 mutations represent a critical biomarker for disease progression and therapeutic response in prostate cancer. Advances in detection methods and targeted therapies hold significant potential to improve outcomes for patients with TP53-mutated prostate cancer. Further research is essential to integrate TP53-based strategies into routine clinical practice. Full article
(This article belongs to the Special Issue The Role of Genes in Prostate Cancer)
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21 pages, 2488 KiB  
Review
Deciphering the Tumor Microenvironment in Prostate Cancer: A Focus on the Stromal Component
by Hubert Pakula, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Pier Vitale Nuzzo, Silvia Rodrigues and Massimo Loda
Cancers 2024, 16(21), 3685; https://doi.org/10.3390/cancers16213685 - 31 Oct 2024
Cited by 2 | Viewed by 2104
Abstract
Prostate cancer progression is significantly affected by its tumor microenvironment, in which mesenchymal cells play a crucial role. Stromal cells are modified by cancer mutations, response to androgens, and lineage plasticity, and in turn, engage with epithelial tumor cells via a complex array [...] Read more.
Prostate cancer progression is significantly affected by its tumor microenvironment, in which mesenchymal cells play a crucial role. Stromal cells are modified by cancer mutations, response to androgens, and lineage plasticity, and in turn, engage with epithelial tumor cells via a complex array of signaling pathways and ligand–receptor interactions, ultimately affecting tumor growth, immune interaction, and response to therapy. The metabolic rewiring and interplay in the microenvironment play an additional role in affecting the growth and progression of prostate cancer. Finally, therapeutic strategies and novel clinical trials with agents that target the stromal microenvironment or disrupt the interaction between cellular compartments are described. This review underscores cancer-associated fibroblasts as essential contributors to prostate cancer biology, emphasizing their potential as prognostic indicators and therapeutic targets. Full article
(This article belongs to the Special Issue The Role of Genes in Prostate Cancer)
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