RNA Drugs in Tumor Microenvironment

Dear Colleagues,

The presence of a complex tumor microenvironment (TME) is recognized to play a crucial role in tumor progression, resistance to therapy, and spreading across the major cancer types, emphasizing the need of precise-targeting therapeutic molecules.

Indeed, RNA-drugs—including siRNAs, miRNAs/antimiRs, lncRNAs, RNA guides (gRNAs), saRNAs, aptamers and ASOs—are emerging as new classes of precise and safe therapeutic drugs for several undruggable disorders, including cancer. On the other hand, several extracellular ncRNAs have recently been implicated in cancer intracellular communication and in TME–tumor interplay.

As such, this Special Issue is intended to highlight the recent advances in understanding the TME–tumor interplay and to underscore the advantages and limitations of using RNA-based therapeutics to target the TME.

Dr. Vittorio de Franciscis
Guest Editor

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