Prostate Cancer: Pathophysiology, Pathology and Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 25 September 2024 | Viewed by 82551
Special Issue Editor
Special Issue Information
Dear Colleagues,
Prostate cancer is a major healthcare challenge in the developed world and represents the second most common cause of cancer death in men. A remarkable heterogeneity is noted in its clinical course. Some patients have indolent cancer that will never progress, whereas others have remarkably aggressive disease with rapid progression to metastases and resistance to therapy. In between are patients with initially localized disease that will progress to metastatic incurable disease after a variable time period. The clinical heterogeneity of prostate cancer is a reflection of its molecular heterogeneity and the emergence of lineage plasticity. Recent research has provided significant advances in the understanding of the molecular, genomic and epigenetic features of prostate cancer and, as a result, multiple therapeutic options have been added to our armamentarium. In addition, potential new therapeutic targets have been identified and are being tested in preclinical and clinical studies. An active search for efficient predictive biomarkers aiming at delivering the right drug to the right person is currently in place and will define a new era of personalized treatment for prostate cancer. This Topical Collection welcomes articles outlining the pathologic and molecular features of prostate cancer as well as those focusing on the current and emerging therapeutic options and predictive biomarkers for this disease in an effort to summarize current advances in precision medicine approaches.
Dr. Vasiliki Tzelepi
Collection Editor
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Keywords
- prostate cancer
- pathology
- grade
- androgen signaling
- castrate-resistance
- neuroendocrine carcinoma
- lineage plasticity
- epigenetics
- predictive biomarkers
- targeted therapy
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