PARPs in Cancer

Dear Colleagues,

The key role of Poly (ADP-ribose) polymerases (PARPs) in the DNA damage response to single-stranded breaks has been recognized for several decades. However, interest in PARPs as a target in cancer therapy was greatly increased with the discovery that PARP inhibition is synthetically lethal with defects in homologous recombination, most notably in breast and ovarian cancers with loss of BRCA function. This led to the rapid development and regulatory approval of several PARP inhibitors that are now established in clinical use.

Despite this early success, there are still major unanswered questions about the role of PARPs in cancer, and how to further develop PARP inhibitors beyond their use in BRCA-deficient disease. This Special Issue will highlight both the roles of PARP family members in cancer and approaches that aim to expand our biological understanding and future clinical potential of PARP inhibitors either as a monotherapy or in combination with established or emerging anti-cancer agents.

Prof. Anderson Joseph Ryan
Guest Editor

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