Gene and Cell Therapy for Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1235

Special Issue Editor


E-Mail Website
Guest Editor
Department of Ophthalmology, University of North Carolina, Chapel Hill, NC, USA
Interests: uveal melanoma; breast cancer; adeno-associated virus; DNA replication/repair; cell cycle; gene therapy

Special Issue Information

Dear Colleagues,

Due to the heterogenous nature of cancer cells both among and within individual tumors, canonical cell and gene therapy approaches over the last few decades have focused on non-genetic approaches, such as enhancing cancer cell transduction, interfering with attributes of tumor physiology, and broad-based immunotherapy approaches. With the completion of The Cancer Genome Atlas Project, molecular characterization data are now publicly available for 33 different tumor types and contain more than 20,000 individual primary tumor samples. The availability of these data presents an intriguing and exciting opportunity for the broader cell and gene therapy community to identify common aberrant signaling networks in multiple tumor types and explore novel molecular-based targets for the development of potential therapeutics. This Special Issue welcomes all studies highlighting the potential for these new approaches and molecular targets for use in cancer gene and cell therapy applications.

Dr. Jacquelyn J. Bower
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer gene therapy
  • cell therapy
  • adeno-associated virus
  • lentivirus
  • immunotherapy
  • oncolytic viruses
  • cancer stem cells
  • targeted therapy
  • precision medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

24 pages, 4096 KiB  
Review
Gene and Cell Therapy for Sarcomas: A Review
by Sant P. Chawla, Skyler S. Pang, Darshit Jain, Samantha Jeffrey, Neal S. Chawla, Paul Y. Song, Frederick L. Hall and Erlinda M. Gordon
Cancers 2025, 17(7), 1125; https://doi.org/10.3390/cancers17071125 - 27 Mar 2025
Viewed by 583
Abstract
Background: The heterogeneity of sarcomas and resulting distinct sub-type specific characteristics, their high recurrence rates, and tendency for distant metastasis, continue to present significant challenges to providing optimal treatments. Objective: To provide a comprehensive review of current literature and clinical trials [...] Read more.
Background: The heterogeneity of sarcomas and resulting distinct sub-type specific characteristics, their high recurrence rates, and tendency for distant metastasis, continue to present significant challenges to providing optimal treatments. Objective: To provide a comprehensive review of current literature and clinical trials in gene and cell therapies for sarcomas. Methods: A comprehensive literature search was conducted utilizing the following databases: PubMed, Medline, Google Scholar and clinicaltrials.gov. Search terms included “gene therapy”, “cell therapy”, “NK cell therapy, “CAR-T therapy”, “virotherapy”, “sarcoma”, “gene therapy”, and “solid tumors”. Additional sources were identified through manual searching for references of relevant studies. No language restrictions were set. The NCT number, study status, condition, and phase were noted for clinical trials. Results: There are only three gene and cell therapies for sarcomas that have been approved by a federal regulatory agency. Rexin-G: the first tumor-targeted gene therapy vector designed to target all advanced solid malignancies, including chemo-refractory osteosarcomas and soft tissue sarcomas, was approved by the Philippine FDA in 2007. Gendicine was the first oncolytic virus approved for intratumoral delivery in China in 2003. Afami-cel, an innovative chimeric antigen receptor (CAR) T cell therapy, was approved for synovial sarcoma in the United States in 2024. Other promising therapies are discussed in the text. Conclusions: The future of gene and cell therapy for sarcomas holds great promise, as research moves to late-stage clinical development. The integration of gene and cell therapies into standard sarcoma treatment protocols has the potential to significantly improve the quality of life and outcomes for patients with this rare and challenging group of cancers. Full article
(This article belongs to the Special Issue Gene and Cell Therapy for Cancers)
Show Figures

Figure 1

Back to TopTop