Molecular Mechanisms of Cancer: Focus on Metabolism and Microenvironment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (28 November 2022) | Viewed by 13102
Special Issue Editor
Special Issue Information
Dear Colleagues,
The impact of cancer cells on their environment (both locally and distantly) is known to promote malignancy and chemoresistance. Cancers are not just composed of malignant cells but are a complex mass to which many other cells are recruited; this process can contribute to cell transformation. Interactions between transformed and non-malignant cells represent the tumor microenvironment (TME). Intercellular communication is driven by a complex and dynamic metabolism. Moreover, metabolism is a hallmark of cancer and a critical target for cancer therapy. Cancer metabolism is regulated by the autonomous mechanism of the cell as well as metabolite availability in the TME.
Understanding the interactions between the cancer cell and environmental metabolism will be critical for combining metabolism-targeted therapies with chemotherapies. It is known that cancer cells compete with T cells for glucose in tumors and that restricting T cell glucose metabolism causes lymphocyte exhaustion. Other nutrient levels can affect both cancer and immune cells. The relationship between tumors and other organ systems is not limited to the immune system. Endothelial cells also undergo factor-induced metabolic reprogramming. Cancer also causes alterations in whole-body metabolism that may influence tumor-nutrient availability. Modulating the amino acid composition of the diet can slow cancer growth, and investigation into how diet affects tumor growth remains an underexplored area.
Different studies suggest that targeting the metabolism involved in the communication between the non-malignant cells and the malignant cells could be a new treatment option.
Dr. Laetitia Linares
Guest Editor
Manuscript Submission Information
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Keywords
- cancer
- malignancy
- chemoresistance
- tumor microenvironment
- targeting metabolism
- cancer growth
- non-malignant cells
- malignant cells