Immunotherapy of Solid Tumors and New Ideas of Anti-tumor Metastasis

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 2308

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Guest Editor
Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany
Interests: cancer immuotherapy; biomarker; immune modulation and reconstitution
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Special Issue Information

Dear Colleagues,

Immunotherapy has created new treatment ideas for the treatment of many cancers, and the quality of life of patients has also been greatly improved. Although immunotherapy has made exciting progress in the treatment of many cancers, such as the use of CAR-T cell therapy to treat tumors, the success of cancer immunotherapy in solid tumors has been limited. In order to challenge the difficulties caused by the immunosuppressive microenvironment that suppresses immune responses, inefficient transport, and heterogeneity of tumor antigens, novel methods have been developed. Research and clinical experience need to be unlocked.

This Special Issue welcomes the submission of comprehensive research article or reviews. 

Dr. Antonia Busse
Guest Editor

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Keywords

  • immunotherapy
  • solid tumors
  • checkpoint molecules
  • immunomodulation
  • combination therapy
  • cell therapy
  • biomarkers
  • tumor antigens

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Published Papers (1 paper)

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Review

21 pages, 911 KiB  
Review
Insights into the Relationship Between the Gut Microbiome and Immune Checkpoint Inhibitors in Solid Tumors
by Sona Ciernikova, Aneta Sevcikova, Maria Novisedlakova and Michal Mego
Cancers 2024, 16(24), 4271; https://doi.org/10.3390/cancers16244271 - 23 Dec 2024
Cited by 1 | Viewed by 1864
Abstract
Immunotherapy with immune checkpoint inhibitors represents a revolutionary approach to the treatment of solid tumors, including malignant melanoma, lung cancer, and gastrointestinal malignancies. Anti-CTLA-4 and anti-PD-1/PDL-1 therapies provide prolonged survival for cancer patients, but their efficacy and safety are highly variable. This review [...] Read more.
Immunotherapy with immune checkpoint inhibitors represents a revolutionary approach to the treatment of solid tumors, including malignant melanoma, lung cancer, and gastrointestinal malignancies. Anti-CTLA-4 and anti-PD-1/PDL-1 therapies provide prolonged survival for cancer patients, but their efficacy and safety are highly variable. This review focuses on the crucial role of the gut microbiome in modulating the efficacy and toxicity of immune checkpoint blockade. Studies suggest that the composition of the gut microbiome may influence the response to immunotherapy, with specific bacterial strains able to promote an anti-tumor immune response. On the other hand, dysbiosis may increase the risk of adverse effects, such as immune-mediated colitis. Interventions aimed at modulating the microbiome, including the use of probiotics, prebiotics, fecal microbial transplantation, or dietary modifications, represent promising strategies to increase treatment efficacy and reduce toxicity. The combination of immunotherapy with the microbiome-based strategy opens up new possibilities for personalized treatment. In addition, factors such as physical activity and nutritional supplementation may indirectly influence the gut ecosystem and consequently improve treatment outcomes in refractory patients, leading to enhanced patient responses and prolonged survival. Full article
(This article belongs to the Special Issue Immunotherapy of Solid Tumors and New Ideas of Anti-tumor Metastasis)
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