Adhesive Networks in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 5667
Special Issue Editors
Interests: gastrointestinal cancers; cadherin disorders; cancer genetics; cancer cell invasion
Interests: cell-cell adhesion; CDH1 variants; extracellular matrix; Hereditary Diffuse Gastric Cancer
Interests: metastatic breast cancer; cell–cell adhesion; cancer cell invasion; stemness; cancer metabolism; circulating tumor cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cell-cell and cell-extracellular matrix adhesion is a dynamic process responsible for the maintenance of polarized and differentiated epithelia. Adhesion molecules, such as cadherins and integrins, coordinate a mechanical circuit that integrates cell linkages with neighboring cells and substrates, contractile forces and biochemical signals to sustain a functional epithelial barrier.
In the past decade, evidence has emerged demonstrating that, in cancer, adhesion molecules are frequently altered through genetic, transcriptional and post-translational mechanisms. These alterations cause an imbalance in mechanical loads and impose adaptation of the cell’s morphology, leading to increased cell plasticity and a remarkable capacity to overcome the unfavorable conditions of the tumor microenvironment. This phenomenon is a crucial event for tumor progression and spreading into adjacent and distant tissues, which represent the leading cause of cancer mortality.
Herein, we propose to assemble a comprehensive understanding of the current and future challenges surrounding the adhesive networks in cancer. We welcome original articles, reviews and short communications.
Prof. Dr. Raquel Seruca
Dr. Joana Figueiredo
Dr. Joana Paredes
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- cell–cell adhesion
- cadherins
- integrins
- cytoskeleton
- polarity
- mechanotransduction
- extracellular matrix
