CAR T Cells for Cancer Immunotherapy Current Challenges and Future Perspectives
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 2407
Special Issue Editors
Interests: immunotherapy; CAR T cells; solid tumors; acute leukemia; hematopoietic stem cell transplantation; oncolytic viruses
Special Issues, Collections and Topics in MDPI journals
Interests: immunotherapy; CAR T cells; solid tumors; acute leukemia; hematopoietic stem cell transplantation; oncolytic viruses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunotherapy was a major breakthrough in the treatment of patients affected by malignancies. One of the most promising forms of immunotherapy to date is that using chimeric antigen receptor (CAR)-modified T cells, which redirects the specificity of T cells to an antigen expressed by tumor cells in an MHC-independent fashion. The success of the approach, mainly in the hematological field, is confirmed by the various CAR T cell platforms that have been approved by American and European regulatory agencies in the last 6 years. Moreover, recently, CAR T cells also resulted in promising efficacy in different settings, such as the treatment of immune-mediated disorders with a documented pathogenic role of B cells, including, but not limited to, systemic lupus erythematosus.
Together with the great success and with the new potential applications of the approach, limitations of the efficacy of CAR T cells have also emerged. In this Special Issue, we will evaluate CAR T cell approaches representing an innovation in the field, either in terms of proof-of-concept of new indications or in terms of new construct and/or manufacturing techniques. We invite original research papers, brief research reports, reviews and professional opinions that will address these important aspects.
Dr. Francesca Del Bufalo
Guest Editor
Marco Becilli
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- CAR T cells
- immunotherapy
- acute leukemia
- lymphoma
- myeloma
- systemic lupus erythematosus
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