Relationship Between Protein and Metabolite in Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 694

Special Issue Editor


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Guest Editor
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: liver cancer; metabolic reprogramming; mitochondrial metabolism; hexokinases

Special Issue Information

Dear Colleagues,

The intricate interplay between proteins and metabolites in the realm of cancer represents a captivating frontier in scientific exploration. This dynamic relationship, explored in the upcoming Special Issue titled "Relationship between Protein and Metabolite in Cancers" promises to unveil novel insights into the molecular intricacies that underlie cancer progression. From deciphering signaling pathways to understanding metabolic dysregulations, this collection of research articles aims to shed light on the pivotal role played by proteins and metabolites in orchestrating the complex cellular processes within cancer cells. As we delve into this multifaceted connection, we anticipate that the revelations within this Special Issue will deepen our comprehension of cancer biology and pave the way for innovative therapeutic strategies and interventions. It is an exciting journey into the heart of molecular intricacies, poised to redefine our understanding of cancer at its core.

Dr. Md. Wasim Khan
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer progression
  • cancer cells
  • proteins
  • metabolites
  • signaling pathway
  • metabolic dysregulations

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Published Papers (1 paper)

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Review

16 pages, 1015 KiB  
Review
Unveiling the Maze: Branched-Chain Amino Acids Fueling the Dynamics of Cancer Metabolism and Progression
by Kai Xu, Pratham Shah, Dhruvi Makhanasa and Md. Wasim Khan
Cancers 2025, 17(11), 1751; https://doi.org/10.3390/cancers17111751 - 23 May 2025
Viewed by 375
Abstract
Branched-chain amino acids (BCAAs) are essential for protein synthesis and play a crucial role in activating signaling pathways that regulate cell growth and division. Growing evidence reveals their complex role in cancer, particularly in how they support the metabolic reprogramming of tumor cells. [...] Read more.
Branched-chain amino acids (BCAAs) are essential for protein synthesis and play a crucial role in activating signaling pathways that regulate cell growth and division. Growing evidence reveals their complex role in cancer, particularly in how they support the metabolic reprogramming of tumor cells. BCAAs contribute to an environment that promotes tumor growth and survival by affecting energy balance and key cellular signaling networks. This review highlights recent advances in understanding how BCAAs influence cancer metabolism, emphasizing their dual function as both essential nutrients and sources of metabolic fuel. It also explores how BCAAs interact with other metabolic pathways, revealing potential targets for therapy. By uncovering these cancer-specific dependencies on BCAAs, this work points to promising strategies for disrupting tumor progression and developing new treatment approaches. Full article
(This article belongs to the Special Issue Relationship Between Protein and Metabolite in Cancers)
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