Language Dysfunction in Posterior Cortical Atrophy
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 1793
Special Issue Editor
Interests: atypical Alzheimer’s disease; posterior cortical atrophy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Patients with posterior cortical atrophy (PCA) syndrome, an atypical variant of Alzheimer’s disease (AD), experience gradually progressive visuospatial deficits during the initial phase of the illness. As the underlying neurodegenerative disease progresses, the language domain becomes impacted as PCA patients develop deficits in word retrieval, reading, writing, and spelling. The mechanisms of this secondary aphasia syndrome and associations with visuospatial functions remain largely unknown.
Research into the clinical, neuroanatomical, and neuropathological features of these and other PCA symptoms may not only facilitate earlier and more accurate diagnosis, but also ultimately inform the inclusion of these patients in clinical treatment trials.
This Special Issue will highlight multiple approaches that could help improve the characterization, diagnosis, and mechanistic understanding of PCA, with a particular focus on how language is impacted in this syndrome. We will feature new investigations that shed light on the relationships between these clinical symptoms and biomarkers, including molecular PET, hypometabolism profiles (18F FDG-PET), brain structural and functional MRI, and fluid biomarkers (CSF and plasma). Through this effort, we hope to inspire new collaborations and research ideas across the PCA and atypical AD research community.
Dr. Deepti Putcha
Guest Editor
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Keywords
- Alzheimer’s disease
- atypical AD
- visual variant
- posterior cortical atrophy
- reading
- spelling
- writing
- visual
- visuospatial
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