Clearing Pathogenic Proteins from the CNS to Treat Neurodegenerative Diseases
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Developmental Neuroscience".
Deadline for manuscript submissions: closed (11 June 2021) | Viewed by 601
Special Issue Editors
2. Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain
Interests: neurodegenerative disorders; Alzheimer's disease; Huntington's disease; mouse models; protein aggregates; neurogenesis; microRNAs; exercise; CSF sink
Special Issues, Collections and Topics in MDPI journals
Interests: Alzheimer; Parkinson; Biomarker; Frontotemporal Dementia; Lewy Bodies Dementia; Huntington; amyloid; tau; tdp43; synuclein
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As most neurodegenerative diseases are proteinopathies, reducing pathogenic proteins from the brain tissue remains the most straightforward therapeutic approach. Inhibiting the production of these pathogenic proteins or increasing their clearance have shown promise in animal models. While most clinical trials failed to date, alternative methods are needed to promote the clearance of pathogenic proteins in order to modify disease progression. Recently, alternative therapeutic interventions such as albumin exchange in Alzheimer's disease and antisense oligonucleotide intrathecal administration in Huntington's disease, open a door to new ways of clearing pathogenic proteins from the CNS. These approaches suggest that it is possible to modify disease progression acting through the different compartments present in the CNS, giving rise to the development of new technologies that enable the development of innovative therapies.
Prof. Dr. Cristina Tomas-Zapico
Dr. Manuel Menéndez-González
Guest Editors
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Keywords
- Alzheimer’s disease
- Parkinson’s disease
- Amyotrophic Lateral Sclerosis
- Frontotemporal dementia
- Huntington’s disease
- Lewy bodies dementia
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