Alpha-Synuclein in Neurodegenerative Disorders: From Pathogenesis to Potential Therapies

Dear Colleagues,

Neurodegenerative disorders, including Parkinson's disease, multiple system atrophy, Lewy body dementia, and other synucleinopathies, present a significant challenge to modern medicine due to their complex pathology and progressive nature. Central to the pathology of these disorders is the role of alpha-synuclein. The aggregation of alpha-synuclein has been implicated in neuronal dysfunction and death, contributing to the clinical manifestations of these diseases. Notably, alpha-synuclein pathology also connects with other neurodegenerative disorders, underscoring its significance as a target for research and therapeutic development.

This Special Issue of Brain Sciences aims to bring cutting-edge research and reviews that explore the multifaceted roles of alpha-synuclein in neurodegenerative disorders. We invite submissions that cover, but are not limited to, the following topics:

• Molecular mechanisms of alpha-synuclein aggregation and toxicity;
• Genetic and environmental factors influencing synucleinopathies;
• Alpha-synuclein as a biomarker for early diagnosis and progression of neurodegenerative diseases;
• Therapeutic strategies targeting alpha-synuclein pathology;
• Comparative studies of alpha-synuclein's role across different neurodegenerative disorders;
• Advances in imaging and tracking alpha-synuclein in vivo.

We welcome original research articles, comprehensive reviews, and insightful commentaries that contribute to this vital field of study.

Dr. Tuane C.R.G. Vieira
Dr. Yraima Cordeiro
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.