Advances in Deep Brain Stimulation for Parkinson's Disease and Other Movement Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Sensory and Motor Neuroscience".

Deadline for manuscript submissions: closed (27 December 2024) | Viewed by 5564

Special Issue Editor


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Guest Editor
Movement Disorders Center, Department of Neurology, University of São Paulo, São Paulo 05508-010, Brazil
Interests: brain stimulation; movement disorders; Parkinson's disease
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Special Issue Information

Dear Colleagues,

Deep brain stimulation is one of the fastest-growing neuroscience areas, involving both neurological and bioengineering fields, and impacting thousands of patients with several neurological disorders. Through electrical intervention to modulate nervous system functions, DBS technology has dramatically improved motor and non-motor symptoms among the main movement disorders, including Parkinson’s disease, tremor, dystonia, and Tourette’s syndrome. With the evolution of therapy, many advances have been seen, such as new targets and new profiles of patients referred to DBS, as well as newer technologies, such as advanced neuroimaging software and closed-loop systems.

This Special Issue seeks original research and reviews addressing advances in DBS for Parkinson’s disease and other movement disorders. Submissions will be welcomed on the following topics:

  • Neurophysiology to guide adaptive DBS (aDBS) and identify neural biomarkers for different symptoms;
  • Imaging-based programming DBS studies;
  • DBS research that addresses challenging symptoms in Parkinson’s disease, such as gait and balance problems, along with non-motor symptoms;
  • The role of genetics in DBD indications for Parkinson’s disease and dystonia;
  • Cutting-edge artificial intelligence (AI) and the computational modeling of DBS;
  • New targets and new advanced programming strategies;
  • Critical features to be incorporated into future DBS devices.

Dr. Rubens Gisbert Cury
Guest Editor

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Keywords

  • Parkinson’s disease
  • deep brain stimulation
  • tremor
  • dystonia
  • Tourette’s syndrome
  • technology
  • genetics
  • imaging
  • electrophysiology

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Published Papers (2 papers)

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Review

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16 pages, 602 KiB  
Review
New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review
by Renata Montes Garcia Barbosa, Miriam Carvalho Soares, Denise Maria Meneses Cury Portela, Thiago Gonçalves Guimarães and Rubens Gisbert Cury
Brain Sci. 2024, 14(7), 638; https://doi.org/10.3390/brainsci14070638 - 26 Jun 2024
Cited by 3 | Viewed by 3569
Abstract
Deep Brain Stimulation (DBS) is an effective treatment option for patients with dopaminergic complications of Parkinson’s disease (PD) and drug-refractory PD tremor. However, DBS and its indications can be challenging, and they are not often debated in the medical community. Through a critical [...] Read more.
Deep Brain Stimulation (DBS) is an effective treatment option for patients with dopaminergic complications of Parkinson’s disease (PD) and drug-refractory PD tremor. However, DBS and its indications can be challenging, and they are not often debated in the medical community. Through a critical narrative review, the objective of this paper is to improve the comprehension of DBS indications and help to solve the puzzle that this process can be. Proper patient selection is the first step for a good surgical outcome. In this review, then, relevant considerations are discussed, involving PD genes, PD phenotypes, indications of early stages, non-motor symptoms, neuroimaging predictors, comorbidities, and age. Individualized approaches are encouraged, including clinical and radiological factors. Social support during the whole follow-up and expectations alignment are necessary through this process and are also debated. Full article
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7 pages, 580 KiB  
Brief Report
Video-Guided Optimization of Stimulation Settings in Patients with Parkinson’s Disease and Deep Brain Stimulation
by Hannah Jergas, Julia K. Steffen, Charlotte Schedlich-Teufer, Joshua N. Strelow, Johanna Kramme, Gereon R. Fink, Veerle Visser-Vandewalle, Michael T. Barbe and Jochen Wirths
Brain Sci. 2024, 14(9), 914; https://doi.org/10.3390/brainsci14090914 - 11 Sep 2024
Cited by 1 | Viewed by 1322
Abstract
Deep brain stimulation (DBS) for Parkinson’s disease (PD) often necessitates frequent clinic visits for stimulation program optimization, with limited experience in remote patient management. Due to the resource-intensive nature of these procedures, we investigated a way to simplify stimulation optimization for these patients [...] Read more.
Deep brain stimulation (DBS) for Parkinson’s disease (PD) often necessitates frequent clinic visits for stimulation program optimization, with limited experience in remote patient management. Due to the resource-intensive nature of these procedures, we investigated a way to simplify stimulation optimization for these patients that allows for the continuous monitoring of symptoms while also reducing patient burden and travel distances. To this end, we prospectively recruited ten patients treated with DBS for PD to evaluate the feasibility of telemedicinal optimization in a home-based setting. Patients recorded daily videos of a modified Unified Parkinson’s Disease Rating Scale (UPDRS) III, which experienced DBS physicians located at the clinic assessed to provide instructions on adjusting stimulation settings using a handheld programmer with previously set programs as well as patient amplitude control. This study concluded with significant improvements in participants’ motor status as measured by the UPDRS-III (p = 0.0313) compared to baseline values. These findings suggest that remote video-guided optimization of DBS settings is feasible and may enhance motor outcomes for patients. Full article
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