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Advances in Deep Brain Stimulation for Parkinson's Disease and Other...
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Advances in Deep Brain Stimulation for Parkinson's Disease and Other Movement Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Sensory and Motor Neuroscience".

Deadline for manuscript submissions: closed (27 December 2024) | Viewed by 6731

Special Issue Editor

Dr. Rubens Gisbert Cury

E-Mail Website
Guest Editor
Movement Disorders Center, Department of Neurology, University of São Paulo, São Paulo 05508-010, Brazil
Interests: brain stimulation; movement disorders; Parkinson's disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Deep brain stimulation is one of the fastest-growing neuroscience areas, involving both neurological and bioengineering fields, and impacting thousands of patients with several neurological disorders. Through electrical intervention to modulate nervous system functions, DBS technology has dramatically improved motor and non-motor symptoms among the main movement disorders, including Parkinson’s disease, tremor, dystonia, and Tourette’s syndrome. With the evolution of therapy, many advances have been seen, such as new targets and new profiles of patients referred to DBS, as well as newer technologies, such as advanced neuroimaging software and closed-loop systems.

This Special Issue seeks original research and reviews addressing advances in DBS for Parkinson’s disease and other movement disorders. Submissions will be welcomed on the following topics:

  • Neurophysiology to guide adaptive DBS (aDBS) and identify neural biomarkers for different symptoms;
  • Imaging-based programming DBS studies;
  • DBS research that addresses challenging symptoms in Parkinson’s disease, such as gait and balance problems, along with non-motor symptoms;
  • The role of genetics in DBD indications for Parkinson’s disease and dystonia;
  • Cutting-edge artificial intelligence (AI) and the computational modeling of DBS;
  • New targets and new advanced programming strategies;
  • Critical features to be incorporated into future DBS devices.

Dr. Rubens Gisbert Cury
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s disease
  • deep brain stimulation
  • tremor
  • dystonia
  • Tourette’s syndrome
  • technology
  • genetics
  • imaging
  • electrophysiology

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Published Papers (3 papers)

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18 pages, 868 KiB  
Review
The Effects of Deep Brain Stimulation on Balance in Parkinson’s Disease as Measured Using Posturography—A Narrative Review
by Bradley Lonergan, Barry M. Seemungal, Matteo Ciocca and Yen F. Tai
Brain Sci. 2025, 15(5), 535; https://doi.org/10.3390/brainsci15050535 - 21 May 2025
Viewed by 508
Abstract
Background: Postural imbalance with falls affects 80% of patients with Parkinson’s disease (PD) at 10 years. Standard PD therapies (e.g., levodopa and/or deep brain stimulation—DBS) are poor at improving postural imbalance. Additionally, the mechanistic complexity of interpreting postural control is a major barrier [...] Read more.
Background: Postural imbalance with falls affects 80% of patients with Parkinson’s disease (PD) at 10 years. Standard PD therapies (e.g., levodopa and/or deep brain stimulation—DBS) are poor at improving postural imbalance. Additionally, the mechanistic complexity of interpreting postural control is a major barrier to improving our understanding of treatment effects. In this paper, we review the effects of DBS on balance as measured using posturography. We also critically appraise the quantitative measures and analyses used in these studies. Methods: A literature search was performed independently by 2 researchers using the PUBMED database. Thirty-eight studies are included in this review, with DBS at the subthalamic nucleus (STN-) (n = 25), globus pallidus internus (GPi-) (n = 6), ventral intermediate nucleus (VIM)/thalamus (n = 2), and pedunculopontine nucleus (PPN) (n = 5). Results: STN- and GPi-DBS reduce static sway in PD and mitigate the increased sway from levodopa. STN-DBS impairs automatic responses to perturbations, whilst GPi-DBS has a more neutral effect. STN-DBS may promote protective strategies following external perturbations but does not improve adaptation. The evidence regarding the effects on gait initiation is less clear. Insufficient evidence exists to make conclusions regarding VIM- and PPN-DBS. Conclusions: STN- and GPi-DBS have differing effects on posturography, which suggests site-specific and possibly non-dopaminergic mechanisms. Posturography tests should be utilised to answer specific questions regarding the mechanisms of and effects on postural control following DBS. We recommend standardising posturography measures and test conditions by expert consensus and greater long-term data collection, utilising ongoing DBS registries. Full article
(This article belongs to the Special Issue Advances in Deep Brain Stimulation for Parkinson's Disease and Other Movement Disorders)
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16 pages, 602 KiB  
Review
New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review
by Renata Montes Garcia Barbosa, Miriam Carvalho Soares, Denise Maria Meneses Cury Portela, Thiago Gonçalves Guimarães and Rubens Gisbert Cury
Brain Sci. 2024, 14(7), 638; https://doi.org/10.3390/brainsci14070638 - 26 Jun 2024
Cited by 3 | Viewed by 4130
Abstract
Deep Brain Stimulation (DBS) is an effective treatment option for patients with dopaminergic complications of Parkinson’s disease (PD) and drug-refractory PD tremor. However, DBS and its indications can be challenging, and they are not often debated in the medical community. Through a critical [...] Read more.
Deep Brain Stimulation (DBS) is an effective treatment option for patients with dopaminergic complications of Parkinson’s disease (PD) and drug-refractory PD tremor. However, DBS and its indications can be challenging, and they are not often debated in the medical community. Through a critical narrative review, the objective of this paper is to improve the comprehension of DBS indications and help to solve the puzzle that this process can be. Proper patient selection is the first step for a good surgical outcome. In this review, then, relevant considerations are discussed, involving PD genes, PD phenotypes, indications of early stages, non-motor symptoms, neuroimaging predictors, comorbidities, and age. Individualized approaches are encouraged, including clinical and radiological factors. Social support during the whole follow-up and expectations alignment are necessary through this process and are also debated. Full article
(This article belongs to the Special Issue Advances in Deep Brain Stimulation for Parkinson's Disease and Other Movement Disorders)
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7 pages, 580 KiB  
Brief Report
Video-Guided Optimization of Stimulation Settings in Patients with Parkinson’s Disease and Deep Brain Stimulation
by Hannah Jergas, Julia K. Steffen, Charlotte Schedlich-Teufer, Joshua N. Strelow, Johanna Kramme, Gereon R. Fink, Veerle Visser-Vandewalle, Michael T. Barbe and Jochen Wirths
Brain Sci. 2024, 14(9), 914; https://doi.org/10.3390/brainsci14090914 - 11 Sep 2024
Cited by 1 | Viewed by 1384
Abstract
Deep brain stimulation (DBS) for Parkinson’s disease (PD) often necessitates frequent clinic visits for stimulation program optimization, with limited experience in remote patient management. Due to the resource-intensive nature of these procedures, we investigated a way to simplify stimulation optimization for these patients [...] Read more.
Deep brain stimulation (DBS) for Parkinson’s disease (PD) often necessitates frequent clinic visits for stimulation program optimization, with limited experience in remote patient management. Due to the resource-intensive nature of these procedures, we investigated a way to simplify stimulation optimization for these patients that allows for the continuous monitoring of symptoms while also reducing patient burden and travel distances. To this end, we prospectively recruited ten patients treated with DBS for PD to evaluate the feasibility of telemedicinal optimization in a home-based setting. Patients recorded daily videos of a modified Unified Parkinson’s Disease Rating Scale (UPDRS) III, which experienced DBS physicians located at the clinic assessed to provide instructions on adjusting stimulation settings using a handheld programmer with previously set programs as well as patient amplitude control. This study concluded with significant improvements in participants’ motor status as measured by the UPDRS-III (p = 0.0313) compared to baseline values. These findings suggest that remote video-guided optimization of DBS settings is feasible and may enhance motor outcomes for patients. Full article
(This article belongs to the Special Issue Advances in Deep Brain Stimulation for Parkinson's Disease and Other Movement Disorders)
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